Age‐specific serum anti‐Müllerian hormone concentration in Japanese women and its usefulness as a predictor of the ovarian response

Abstract

PurposeTo compare the ovarian response predictive ability of anti‐Müllerian hormone (AMH), follicle‐stimulating hormone (FSH), and estradiol (E2) and to determine the age‐specific distribution of serum AMH concentrations of Japanese women.MethodsThis was a multicenter (four‐site), observational, analytic, cross‐sectional Japanese study consisting of two parts: Study 1 (the prediction of the ovarian response of 236 participants who were undergoing controlled ovarian stimulation [COS]) and Study 2 (the distribution of the AMH concentration with an assay of 417 healthy women who were aged 20‐49 years and who had normal menstrual cycles).ResultsThe AMH had a significantly higher predictive value for the normal and high responders than FSH and E2 as a stronger correlation between the ovarian response and AMH was observed than for FSH and E2. The serum AMH concentration decreased proportionally with age.ConclusionThe AMH concentration correlated well with the oocyte count in the patients who were undergoing COS for in vitro fertilization and was shown to predict the risk of ovarian hyperstimulation syndrome among these patients.

Performance of anti‐Müllerian hormone (AMH) levels measured by Beckman Coulter Access AMH assay to predict oocyte yield following controlled ovarian stimulation for in vitro fertilization

“…These findings were similar to the results of a previously reported multicenter, observational study . In this study, we measured AMH by the Access assays in more than 3000 Japanese women and the results indicated that AMH could be an accurate marker of ovarian response to stimulation as observed in the previous Gen II pre‐mix assay.…”

Role of oxidative stress in follicular fluid on embryos of patients undergoing assisted reproductive technology treatment

“…We examined the correlation between each clinical parameters and value of antioxidant capacity. As expected, correlation was found between age, value of AMH and the number of ova collected, and value of AMH and total ovum account decreased as patients ages ( P < 0.001) . Contrary to the previous report, clinical parameters such as age and AMH showed no significant correlation with oxidative and antioxidant markers (Fig.…”

Correlative Analysis Between Serum Anti-mullerian Hormone Concentration and LH:FSH Ratio as Women's Age Advances: A Hospital-based Study

“…On comparison, we found that serum AMH levels were 4.19±1.4, 3.54±1.4, 2.71±1.1 and 1.8±0.8 ng/ml among subjects in 'A', 'B', 'C' and 'D' sets, respec vely (Figure-2). Our findings, therefore, were evident to the established fact that supports declining pa ern of serum 15 AMH concentra ons as age advances.…”

“…So they were separated into four sets as 'A', 'B', 'C' and 'D' having 25-30, 31-35, 36-40 and 41-45 years-old subjects, respec vely. Serum concentra ons of AMH decline as an individual's age 15 advances. So, we evaluated these subjects to rule out the possible varia ons in serum concentra ons of AMH with respect to age.…”