Age-specific seroprevalence of hepatitis A infection among children visited in pediatric hospitals of Tehran, Iran

Mehr, Ali Jafari; Ardakani, Mohammad Javad Ehsani; Hedayati, Mehdi; Shahraz, Saeed; Mehr, Elnaz Jafari; Zali, Mohammad Reza

doi:10.1023/b:ejep.0000020345.37091.cd

Cited by 19 publications

(6 citation statements)

References 22 publications

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“…We found no statistical difference of seroprevalence between boys and girls. Similar to these results, a study on age‐specific seroprevalence of hepatitis A among children in Tehran, Iran found no statistically significant gender differences in prevalence rates 20 …”

Section: Discussionsupporting

confidence: 73%

Hepatitis A seroprevalence and demographics in Turkish children in Ankara

Saç

Bostancı

Dallar

et al. 2009

Pediatrics International

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Section: Discussionsupporting

confidence: 73%

Hepatitis A seroprevalence and demographics in Turkish children in Ankara

Saç

Bostancı

Dallar

et al. 2009

Pediatrics International

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“…Another study on 1018 children (six months to 14.9 years) referred to Tehran pediatrics hospitals in 2002 showed 22.3% HAV seropositivity. The seroprevalence did not differ significantly between males and females and for different age groups ( 26 ). Taghavi et al ( 27 ) reported anti-HAV seropositivity of 88.2% among the adult population in Fars province (Southern Iran) between 2008 and 2009.…”

Section: Discussionmentioning

confidence: 87%

Hepatitis A Virus and Hepatitis E Virus Seroprevalence Among Blood Donors in Tehran, Iran

et al. 2016

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BackgroundHepatitis A virus (HAV) and Hepatitis E virus (HEV) are both transmitted by the fecal-oral route and are known as the leading causes of acute viral hepatitis in the world, especially in developing countries. There is a lack of updated data on HAV and HEV seroprevalence in Iran.ObjectivesThe aim of this study was to determine the seroprevalence of HAV and HEV among a group of blood donors in Tehran, Iran.Materials and MethodsA cross-sectional study was performed from July 2014 to December 2014, on a total of 559 blood donors referred to the Tehran blood transfusion center. The serum samples were tested for antibodies to HAV and HEV, using the enzyme-linked immunosorbent assay.ResultsIn the present study, 536 (95.9%) cases were male and 23 (4.1%) female with mean age of 38 years. Out of 559 blood donors, 107 (19.1%) were first-time donors, 163 (29.2%) lapsed donors and 289 (51.7%) regular donors. Anti-HAV was found in 395 (70.7%) and anti-HEV in 45 (8.1%) of the blood donors. The HAV and HEV seroprevalence increased by age. There was no significant difference between genders in terms of anti-HAV and anti-HEV status. The HAV and HEV seroprevalence was significantly related to the level of education, where the donors with higher level of education had lower rate of HAV and HEV seroprevalence. The HAV and HEV seroprevalence was significantly higher in regular and lapsed donors than in first-time donors.ConclusionsThe present study showed that both HAV and HEV infections are still endemic in Iran.

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“…These rates were increased to 100%, 90.6%, 68%, and 76% on the age of 10-15 years in those cities, respectively. Later to 2000, several seroepidemiological studies were carried out in different populations living in some parts of the country [17][18][19][20][21][22][23][24][26][27][28][29][30][31][32][33]. Results, however, were not uniform.…”

Section: Discussionmentioning

confidence: 99%

Age-Specific Seroprevalence of Anti-Hepatitis A Antibody Among 1-30 Years Old Population of Savadkuh, Mazandaran, Iran With Literature Review

Saffar¹,

Abedian

Ajami

et al. 2012

Hepat Mon

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BackgroundTo determine age-speciﬁc seroprevalence rates of hepatitis A virus (HAV) immunoglobulin G (IgG) antibody in Savadkuh district, Mazandaran province, north of Iran, as well as to compare the collected data with earlier seroprevalence studies in the region and Iran in order to draw a proper epidemiological pattern for HAV infection in the country.ObjectivesThis study aimed to assess an age-speciﬁc HAV seroprevalence among 1- to 30-yearold people in Savadkuh, a less developed district of Mazandaran province, north of Iran.Patients and MethodsThe study participants were 984 subjects who aged from one to 30 years and were residents of rural and urban areas of Savadkuh. They were selected using cluster sampling method and divided into ﬁve age groups: 1-2.9 (316 cases), 3-6.9 (254 cases), 7-10.9 (201 cases), 11-17.9 (115 cases), and 18-30 (98 cases). Anti-HAV antibody was measured by ELISA method. Seroprevalence rates among different age groups and their relationship to residency, educational levels of parents, water supply, and waste water disposal system was analyzed using chi-squared test.ResultsOverall seroprevalence rate was 19.20 % with no signiﬁcant difference between rural and urban residents. The seroprevalence rates increased signiﬁcantly with age: from 5.7 % in age group 1-2.9 year to 34.8 % in adolescents, and to 68.4 % among young adults (P < 0.0001); regardless of signiﬁcant differences in educational levels among parents of residents in two areas it did not affect seroprevalence rates. Findings of this study and reviewing other reports from the region and the country suggest an epidemiological shift towards lower rates of anti-HAV antibody seroprevalence.ConclusionsIt appears that anti-HAV antibody seroprevalence rate has been declining among Iranians and thereby more children would be susceptible to this infection. This would necessitate revising current strategies of preventative measures in Mazandaran and Iran.

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Age-specific seroprevalence of hepatitis A infection among children visited in pediatric hospitals of Tehran, Iran

Abstract: In summary, it seems that HAV infection is not highly endemic at least in some urban areas of Iran. On the basis of this epidemiologic data, post exposure prophylaxis would be necessary for children and young adults, and hepatitis A vaccination strategy should be revised.

Cited by 19 publications

References 22 publications

Hepatitis A seroprevalence and demographics in Turkish children in Ankara

Hepatitis A seroprevalence and demographics in Turkish children in Ankara

Hepatitis A Virus and Hepatitis E Virus Seroprevalence Among Blood Donors in Tehran, Iran

Age-Specific Seroprevalence of Anti-Hepatitis A Antibody Among 1-30 Years Old Population of Savadkuh, Mazandaran, Iran With Literature Review

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