Hepatitis A Virus and Hepatitis E Virus Seroprevalence Among Blood Donors in Tehran, Iran

Hesamizadeh, Khashayar; Sharafi, Heidar; Keyvani, Hossein; Alavian, Seyed Moayed; Shabankareh, Azar Najafi-Tireh; Olyaie, Roghiyeh Sharifi; Keshvari, Maryam

doi:10.5812/hepatmon.32215

Cited by 28 publications

(17 citation statements)

References 27 publications

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“…Similarly, Kaufmann et al had demonstrated a peak in seroprevalence of 5.3% in individuals aged 51 to 70 years old among blood donors in south west Switzerland. In Iranian blood donors' population, a similar increasing trend of HEV seropositivity was observed accounting for about 50% of HEV seropositive donors in the age group of >47 years …”

Section: Discussionsupporting

confidence: 62%

Hepatitis E virus seroprevalence among blood donors in Pune, India

Tripathy

Puranik

Sharma

et al. 2018

Journal of Medical Virology

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Background Blood transfusion is a recently reported route of hepatitis E virus (HEV) transmission. It is a bigger concern in regions where large‐scale HEV genotype 1 infections occur causing more severe disease. The present study aims to assess the prevalence and rate of HEV infection in the blood donors of Pune, India. Materials and Methods A total of 2447 healthy blood donors were screened for anti‐HEV IgG and IgM antibodies. Anti‐HEV IgM antibody positives were further subjected to alanine aminotransferase measurement, HEV RNA detection, viral load quantification and phylogenetic analysis. Results Anti‐HEV seroprevalence rate was 17.70%, while IgM prevalence rate was 0.20%. An age dependent increase in IgG seropositive rate was observed. Two of five IgM‐positives tested positive for HEV RNA. The viral load ranged from 3.5 × 104 to 4.6 × 105 copies/mL and belonged to HEV genotype 1. Conclusions HEV prevalence rate of 17.70% in the blood donors of Pune, India, a developing country, goes at par with the developed countries. Current data of 0.20% (5 of 2447) blood donors positive for anti‐HEV IgM and two of them being HEV RNA positive suggest a need for consideration of cost‐effective evaluation towards pooled HEV RNA testing in blood banks.

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Section: Discussionsupporting

confidence: 62%

Hepatitis E virus seroprevalence among blood donors in Pune, India

Tripathy

Puranik

Sharma

et al. 2018

Journal of Medical Virology

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“…It seems that some countries like Iran are passing from intermediate-to lowendemicity area for HAV infection. Therefore, the role of vaccination should be highlighted in these countries (23).…”

Section: Discussionmentioning

confidence: 99%

Estimation of Hepatitis A Virus Infection Prevalence Among Eastern Mediterranean and Middle Eastern Countries: A Systematic Review and Pooled Analysis

2017

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Context: Hepatitis A virus (HAV) infection is the most common type of acute viral hepatitis that has been proposed as an important public health issue. Most of the countries in WHO Eastern Mediterranean region (EMR) and Middle East (ME) have a high endemicity of HAV infection. To provide a comprehensive estimation of the epidemiology of HAV in this region, we carried out a systematic review on the literature reporting the prevalence of HAV infection in the EMR and ME.Evidence Acquisition: We conducted a systematic search in the databases including PubMed, Scopus, Science Direct, and Web of science using appropriate search strategies. Observational studies published between January 1990 and July 2016 with clearly stated data regarding HAV Ab (IgG) in non-high-risk groups from countries of EMR and ME were examined. We estimated the prevalence of HAV infection and 95% confidence interval based on the pooled data from all included studies for each country, and the regions were weighted according to the population size of each country in that region. Results:The HAV prevalence in ME, WHO EMR, and in total was 61.60 (61.31 -61.89), 65.74 (65.39 -66.09), and 62.60 (62.32 -62.89), respectively. We found no eligible study for Bahrain, Djibouti, Libya, Oman, Qatar, and Sudan. Cyprus had the lowest prevalence rate of HAV (2.61% (1.53 -4.17)) that along with UAE and Kuwait, it had a prevalence rate below 50%. The most HAV prevalence rates were related to ), )), )), and .77)), in sequence. Conclusions:The countries of EMR and ME need more and constant programs for prevention and control of HAV infection. Also, further primary original epidemiological studies are needed in some countries of the region.

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“…Anti-HEV IgG antibodies increase to their peak level by the end of the fourth week and can continue for years (El-Tras et al 2013). HEV is generally transmitted by the fecaloral route, following transfusion with infected blood products, through vertical transmission and also through contact with infected animals (Hesamizadeh et al 2016). Individuals considered to be at high risk of contracting the virus include employees of slaughterhouses, people working on pig farms and veterinarians (Holt et al 2016).…”

Section: Introductionmentioning

confidence: 99%

A Special Risk Group for Hepatitis E Infection: The First Record of North Cyprus

Süer

Güvenir

Aykaç

2018

Polish Journal of Microbiology

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A b s t r a c tHepatitis E virus (HEV) is transmitted by a fecal oral route from animals to humans following exposure to the body fluids of infected animals. We investigated the seroprevalence of anti-hepatitis E (anti-HEV) antibodies by monitoring IgG and IgM virus antibodies amongst employees in the animal industry in North Cyprus through a cross-sectional study. Samples were taken from individuals without occupational exposure to animals and from those who worked with animals (doing animal husbandry, veterinary work or butchery). Enzymelinked immunoassays were used to detect anti-HEV IgG and IgM in the blood samples. The prevalence of anti-HEV IgG antibodies was 3.0% (12/400), while the prevalence of anti-HEV IgM antibodies was 0.25% (1/400). The prevalence of anti-HEV IgG amongst the samples received from females was approximately 2.5-fold higher than samples received from males (2.4%). Anti-HEV IgG was detected amongst 7% of animal husbandry workers and amongst 2% of veterinarians and butchers. The current findings represent the first records of HEV surveillance in Cyprus. We investigated the seroprevalence of anti-HEV by monitoring IgG and IgM virus antibodies amongst employees.

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Hepatitis A Virus and Hepatitis E Virus Seroprevalence Among Blood Donors in Tehran, Iran

Cited by 28 publications

References 27 publications

Hepatitis E virus seroprevalence among blood donors in Pune, India

Hepatitis E virus seroprevalence among blood donors in Pune, India

Estimation of Hepatitis A Virus Infection Prevalence Among Eastern Mediterranean and Middle Eastern Countries: A Systematic Review and Pooled Analysis

A Special Risk Group for Hepatitis E Infection: The First Record of North Cyprus

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