Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2 052 922 and age-specific fertility rates of women with epilepsy

Wallace, H.K.; Shorvon, SD; Tallis, Raymond

doi:10.1016/s0140-6736(98)04512-7

Cited by 355 publications

(206 citation statements)

References 10 publications

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“…Our findings support earlier studies showing that epilepsy may be a predisposing factor for not having children, and that WWE have significantly reduced birth rates after 25 years of age (Wallace et al. 1998). The results thus corroborate the findings from earlier population‐based studies (Wallace et al.…”

Section: Discussionmentioning

confidence: 99%

“…The results thus corroborate the findings from earlier population‐based studies (Wallace et al. 1998; Artama et al. 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal changes and psychosocial problems have been discussed as potential causes (Wallace et al. 1998), but use of antiepileptic drugs (AEDs) may also be of significance. An Indian study that included women with validated epilepsy, reported AED polytherapy as a major risk factor for lack of conception, but this study did not compare birth rates to controls (Sukumaran et al.…”

Section: Introductionmentioning

confidence: 99%

“…The two largest population‐based studies reporting reduced birth rates in epilepsy relied on registry data, but without validation of the epilepsy diagnoses and without detailed clinical information such as epilepsy type and use of contraceptives (Wallace et al. 1998; Artama et al. 2004).…”

Section: Introductionmentioning

confidence: 99%

“…One reported significantly lower birth rates in women aged 25–39 years with nonvalidated epilepsy and taking AEDs compared with birth rates in the general population (Wallace et al. 1998). The other study found 10% lower birth rates among WWE than women without epilepsy (Artama et al.…”

Section: Introductionmentioning

confidence: 99%

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Age‐specific birth rates in women with epilepsy: a population‐based study

et al. 2016

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ObjectiveThe aim of this study was to investigate birth rates and use of hormonal contraception in different age groups among women with epilepsy (WWE) in comparison to women without epilepsy.Materials and MethodsDemographic data and medical information on more than 25,000 pregnant women (40,000 births), representing 95% of all pregnancies in Oppland County, Norway, were registered in the Oppland Perinatal Database in the period 1989–2011. Data were analyzed with respect to epilepsy diagnoses, and 176 women with a validated epilepsy diagnosis (303 pregnancies) were identified. Age‐specific birth rates in these women were estimated and compared with age‐specific birth rates in women without epilepsy in the same county.ResultsIn WWE over 25 years of age, birth rates were significantly lower than in those of the same age group without epilepsy. In women below 20 years of age, birth rates were similar in those with and without epilepsy. The use of hormonal contraceptives prior to pregnancy was lower among WWE under 25 years than in the corresponding age group without epilepsy.ConclusionsHealth professionals who counsel WWE who are of fertile age should be aware of the strongly reduced birth rates in WWE over 25 years of age, and the lower rates of use of contraceptives among young WWE.

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Section: Discussionmentioning

confidence: 99%

“…The results thus corroborate the findings from earlier population‐based studies (Wallace et al. 1998; Artama et al. 2004).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age‐specific birth rates in women with epilepsy: a population‐based study

et al. 2016

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Valproate, Hyperandrogenism, and Polycystic Ovaries

Isojärvi

Tapanainen²

2000

Arch Neurol

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The 3 cases presented here illustrate the development of reproductive endocrine disorders after the initiation of valproate therapy in women with epilepsy. The disorders were characterized by hyperandrogenism and polycystic ovaries in all cases, and were associated with weight gain and menstrual disorders in 2 of the 3 women. An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.

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