Age-specific distribution of estimated glomerular filtration rate using Japanese health checkup data

Takahashi, Toshimasa; Baba, Takehiko; Ogawa, Takumi; Okamoto, Yasuko; Tajima, Tetsuya; Agawa, Tamaki; Kondo, Tsuneo; Yanai, Kunio

doi:10.7143/jhep.43.518

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…As is well-known, UAE is used as a preclinical sign of kidney injury. The median eGFR immediately before surgery was 78.4 mL/min in our series, and this value was relatively better than that in the age-matched general Japanese population (17). In other words, patients with PAHC in our series might less suffer from kidney injury before intervention and then showed marked increasing kidney function.…”

Section: Discussioncontrasting

confidence: 51%

Overweight Patients Less Improved Kidney Function After Laparoscopic Surgery for Adrenocortical Adenoma With Excess Cortisol Secretion

et al. 2019

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Purpose: Glucocorticoid (GC) is known to be involved in the deterioration of kidney function both directly by affecting the glomeruli and renal tubules and indirectly by affecting cardiovascular function. Autonomous GC secretion is the main feature of primary adrenal hypercortisolism (PAHC). However, the ideal treatment option (operation vs. medical treatment and observation) for patients with PAHC has not been established yet. In this study, we assessed a time series of kidney function in patients with PAHC treated via laparoscopic adrenalectomy and investigated the predictive factors for kidney function 1 year after surgery. Methods: From September 1997 to July 2017, 175 laparoscopic adrenalectomies were performed for adrenal tumors at Akita University. Thirty patients, who were diagnosed as having PAHC via preoperative endocrinological evaluations and followed up for at least 1 year after surgery, were included in this study. Patients with severe complications or simultaneous aldosteronism were excluded. The mean age of the 30 patients was 57.5 years (range, 33–79 years; males, 4; females, 26), and the right and left sides were affected in 9 and 21 patients, respectively. Results: In all, 18 patients were diagnosed as having Cushing's syndrome and 12 as having subclinical Cushing's syndrome. The steroid cover was required in all cases after surgery. The estimated glomerular filtration rate significantly improved (78.4 mL/min [64.8–95.8] vs. 84.1 mL/min [66.8–104.0], p = 0.012) 1 year after surgery. Patients showing 5% or more improvement in kidney function and those showing less than 5% improvement were compared. On performing univariate analyses, factors such as a longer operative time, heavy body mass index (BMI), and preoperative unsuppressed ACTH were associated with worse improvement in kidney function. No significant associations were observed regarding metabolic disorders, clinical symptoms, and gross proteinuria. On multivariate analysis, patients with a higher BMI (≥ 24 kg/m 2 ) showed worse improvement in kidney function at 1 year after surgery (odds ratio 14.0, 95% confidence interval 1.3–142.9, p = 0.012). Conclusions: In PAHC patients, after 1 year of follow-up, kidney function improved in terms of estimated glomerular filtration rate. Therefore, this improvement seems to be delayed in overweight patients, suggesting its direct role in renal function.

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Section: Discussioncontrasting

confidence: 51%

Overweight Patients Less Improved Kidney Function After Laparoscopic Surgery for Adrenocortical Adenoma With Excess Cortisol Secretion

et al. 2019

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“…The normal ageing of the kidney and the ageing related decrease of GFR is documented. In Caucasians over 60 years normal eGFR is around 75 ml/min/1.73m 2 in men and 68 ml/min/1.73m 2 in women and in people of Japanese ethnicity is 73 ml/min/1.73m 2 [ 10 , 11 ]. Preexisting hypertension and type 2 DM may further decrease kidney function prior to cancer onset.…”

Section: Discussionmentioning

confidence: 99%

Chronic kidney disease in cancer patients, the analysis of a large oncology database from Eastern Europe

et al. 2022

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Introduction Kidney dysfunction is prevalent in oncology patients and has an impact on their treatment and quality of life. The aim of our study was to analyze the prevalence of CKD in a large cohort of several types of cancer patients in an East European Region. Material and methods We conducted an observational retrospective cohort study on 5831 consecutive, biopsy-diagnosed cancer patients between January 2019 –December 2020 in the largest oncology hospital and outpatient clinic in Western Romania. 4342 subjects were included in the statistical analysis. Results and discussion From the 24 cancer types, the most prevalent cancers were represented by: breast (22.02%), lung (10.18%) and colonic cancer (9.51%). The prevalence of CKD (G3 –G5) was 12.27% after the first year of follow-up and 13.42 after the second year. The prevalence of CKD was higher in patients with renal (50%), urinary tract (33.6%) and pancreatic cancers (19.6%) and lower in patients with colonic cancers (5.3%) and brain tumors (2.5%). At the end of our 2-year survey period, 0,7% of the CKD cases had an eGFR around 6 ml/min/1.73m2 –an indication for renal replacement therapy. Conclusion Oncology patients have a significantly higher prevalence of CKD compared to the general population, dependent of the age of the patients and the type of cancer. The prevalence of advanced CKD was surprisingly high (stages G4-G5 Pre-Dialysis 22.15%) one third of the CKD- G5 patients having indication for initiation of renal replacement therapy. An onco- nephrology team should be needed for the best medical care of these patients.

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The important role of primary care physicians in chronic kidney disease follow-up

Okamoto¹,

Ogawa²,

Baba³

et al. 2016

HEP

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Age-specific distribution of estimated glomerular filtration rate using Japanese health checkup data

Abstract: Objective. The purpose of the study was to determine the distribution of estimated glomerular filtration rate (eGFR) values among the Japanese working generation using representative health checkup data.Design.

Cited by 3 publications

References 15 publications

Overweight Patients Less Improved Kidney Function After Laparoscopic Surgery for Adrenocortical Adenoma With Excess Cortisol Secretion

Overweight Patients Less Improved Kidney Function After Laparoscopic Surgery for Adrenocortical Adenoma With Excess Cortisol Secretion

Chronic kidney disease in cancer patients, the analysis of a large oncology database from Eastern Europe

The important role of primary care physicians in chronic kidney disease follow-up

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