Age‐specific clinicopathological characteristics and prognostic analysis of neuroendocrine carcinomas of the gallbladder

Zhang, Zhiwei; Guo, Tong; Huang, Xiaorui; Xie, Peng; Wang, Lu; Yu, Yahong

doi:10.1002/cam4.4463

Cited by 6 publications

(10 citation statements)

References 33 publications

(84 reference statements)

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“…NECs accounted for the largest number of neoplasms (16/36), with 4 cases being LCNECs and 12 cases being SCNECs, consistent with previous reports that NECs are predominantly SCNECs (17). The expression of markers did not signi cantly differ among the three locations of neoplastic cells and did not have an impact on patient survival.…”

Section: Discussionsupporting

confidence: 87%

Biliary Neuroendocrine Neoplasms: A Clinicopathological and Prognostic Analysis of 36 Clinical Cases

Zhao

Jiang

et al. 2023

Preprint

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Background Biliary neuroendocrine neoplasms are rare diseases characterized by low morbidity, difficult diagnosis, and poor prognosis. In this study, we aimed to provide a better understanding of this disease by analyzing the clinicopathological features, treatment, and factors associated with prognosis of 36 cases of neuroendocrine neoplasms arising from the gallbladder, bile ducts, and ampulla of Vater. Results The early stages of the disease often present with atypical symptoms, leading to a delayed diagnosis in most cases, abdominal discomfort was the primary manifestation at diagnosis. Neuroendocrine carcinoma was the most common pathological stage observed, with small-cell neuroendocrine carcinomas being the predominant subtype. Tumor recurrence occured mostly in the liver. The median follow-up time was 39 months, and the median survival time was 30 months. The 1-, 2-, and 3-year survival rates were 63.9%, 51.0%, and 35.7%, respectively. No significant effects of adjunctive therapy on prognosis were found. Pathological grade and access to R0 margin were found to be significantly associated with overall survival. Conclusions Biliary neuroendocrine neoplasms are challenging to diagnose at an early stage due to the absence of typical symptoms. Liver metastasis is relatively common in desease recurrence and is indicative of a poor prognosis., and poor histological grading and the inability to achieve R0 margin significantly shorten the survival period.

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Section: Discussionsupporting

confidence: 87%

Biliary Neuroendocrine Neoplasms: A Clinicopathological and Prognostic Analysis of 36 Clinical Cases

Zhao

Jiang

et al. 2023

Preprint

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“…Three studies, involving 10, 15, and 28 patients with gallbladder NEN, reported a worse prognosis in patients with gallbladder NEN than those with adenocarcinoma. 10,11,29 In another study of 21 patients, the outcomes were similar. 3 However, another study including 754 patients with gallbladder NEN revealed that the prognosis of gallbladder NEN was better than that of adenocarcinoma.…”

Section: Discussionmentioning

confidence: 87%

“…However, different studies have arrived at different conclusions regarding the prognosis of gallbladder NEN. Three studies, involving 10, 15, and 28 patients with gallbladder NEN, reported a worse prognosis in patients with gallbladder NEN than those with adenocarcinoma 10,11,29 . In another study of 21 patients, the outcomes were similar 3 .…”

Section: Discussionmentioning

confidence: 99%

“…10 Some previous studies suggested that gallbladder NEN was more common in the elderly and females, and its most common subtype was NEC. 9,[11][12][13][14] However, the clinical characteristics of gallbladder NEN remain controversial, and there is still no standard diagnosis and treatment strategy due to its low incidence. To date, the vast majority of treatment and research on gallbladder NEN has been based on a model of gallbladder adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis

Hong

et al. 2023

Cancer Medicine

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Background Neuroendocrine neoplasm (NEN) of the gallbladder is rare. It is usually asymptomatic and occurs in older adults. Its clinicopathological characteristics remain controversial, and the diagnosis and treatment strategies are usually based on models of adenocarcinoma. The present study aimed to investigate the clinical characteristics and prognosis of gallbladder NEN. Methods The data of patients with gallbladder NEN admitted to Peking Union Medical College Hospital was reviewed, and a database was established for retrospective analysis. Clinicopathological features were analyzed descriptively and the prognosis was studied according to different factors. The Kaplan–Meier curve was used to describe the cumulative survival rate. Results In total, 22 patients with gallbladder NEN were included in this study. There were 10 male (45.5%) and 12 female (54.5%) patients with a median age of onset of NEN at 57.5 (49.0, 62.3) years. Abdominal discomfort was the most common symptom. Twenty patients (90.9%) underwent surgery, and two patients (9.1%) with unresectable lesions underwent a biopsy. Twenty‐one patients were followed up. The 1‐, 2‐, and 3‐year cumulative overall survival rates of all patients and patients with resectable lesions were 65.9%, 54.9%, and 48.1%, and 72.9%, 60.7%, and 53.1%, respectively. Patients with resectable lesions had a better cumulative overall survival rate than those who with unresectable lesions (p < 0.001). Conclusion Gallbladder NEN is more common in the elderly and has a slight female predominance. The most common symptom is abdominal discomfort. Surgery is the first choice of treatment for this rare disease. The prognosis of gallbladder NEN is generally poor. Patients with resectable lesions have a better prognosis.

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“…On re‐evaluation, 31 (21.1%) patients were upstaged to either locally advanced or metastatic stages. NEC and MiNEN are aggressive diseases with prognosis worse than adenocarcinoma 2,5,6 . Fifty‐two (35.4%) patients in our series could not receive any treatment due to poor performance status, intractable jaundice, or very advanced nature of the disease.…”

Section: Discussionmentioning

confidence: 85%

Neuroendocrine neoplasms of the gallbladder: A single institute analysis of outcomes and prognostic factors

Nandy,

Patkar,

Yadav

et al. 2024

Journal of Surgical Oncology

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IntroductionNeuroendocrine neoplasms (NENs) are classified as neuroendocrine tumors (NETs), neuroendocrine carcinomas (NECs), and mixed neuroendocrine and nonneuroendocrine neoplasms (MiNENs) according to World Health Organization classification. We present our experience of NENs of the gallbladder (GB) from a high‐volume cancer hospital.Materials and MethodsThe present study is a retrospective analysis of all patients with GB NENs who presented between January 2015 and June 2023. The patient details and treatment received with follow‐up were noted. The primary endpoint was overall survival (OS).ResultsA total of 147 patients were included in the study. The median age was 52 (27–81) years. There was a female predominance (70.7%). NEC was the most common subtype (84.4%) followed by MiNEN (12.9%) and NET (2.7%). The most common stage at presentation was metastatic (70.7%) followed by locally advanced (21.8%), and early disease (7.5%). The median follow‐up was 9.92 (1.77–76.06) months. Median OS was 6.14 (3.93–8.35) months. Median OS in patients who received multimodality treatment was 20.20 (17.99–22.41) months versus 4.00 (2.91–5.10) months in those who did not receive it.ConclusionGB NENs are rare, but aggressive tumors with NEC being the most common type. Multimodality treatment yields favorable outcomes. However, the development of better systemic therapy is needed to help improve survival further.

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Age‐specific clinicopathological characteristics and prognostic analysis of neuroendocrine carcinomas of the gallbladder

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 33 publications

Biliary Neuroendocrine Neoplasms: A Clinicopathological and Prognostic Analysis of 36 Clinical Cases

Biliary Neuroendocrine Neoplasms: A Clinicopathological and Prognostic Analysis of 36 Clinical Cases

Neuroendocrine neoplasm of the gallbladder: Clinical features, surgical efficacy, and prognosis

Neuroendocrine neoplasms of the gallbladder: A single institute analysis of outcomes and prognostic factors

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