Age-specific anti-Mullerian hormone (AMH) levels poorly affects cumulative live birth rate after intra-uterine insemination

Moreau, Jessika; Gatimel, Nicolas; Simon, Cynthia; Cohade, Clémentine; Lesourd, Florence; Parinaud, Jean; Léandri, Roger

doi:10.1016/j.eurox.2019.100043

Cited by 11 publications

(17 citation statements)

References 44 publications

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“…17 However, it is well known that AMH levels are strongly correlated with age. 18 This study demonstrates herein that AMH was a statistically significant predictor of yield utilising univariate analysis, but when controlling for other variables using multivariate analysis, no significant relationship was identified. We propose therefore, that when assessing oocyte yield controlling for confounders such as age; such interrelationships may nullify the impact of AMH.…”

Section: Discussionmentioning

confidence: 71%

Analysis of ten years of social oocyte cryopreservation: a research article

Kasaven¹,

Jones²,

Heath³

et al. 2020

Preprint

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Objective: To assess the relationship between number of oocytes retrieved during social egg freezing (SEF) cycles with various clinical, biochemical and radiological markers; e.g. age, body mass index (BMI), baseline anti-Mullerian hormone (AMH), antral follicle count (AFC), Oestradiol level (E2) and total number of follicles [?]12mm at trigger. Main outcome measures: To describe the characteristics and outcomes of women who underwent SEF. Methods: A retrospective cohort of women embarking on SEF between 2008 and 2018 from a single London UK fertility clinic. Results: 483 stimulation cycles were undertaken in 373 women. The median age at freeze was 38 (26-47) years. The median numbers of oocytes retrieved per cycle was 8 (0-37), and total oocytes cryopreserved 8 (0-45) per woman. BMI, E2 level and number of follicles [?]12mm at trigger were all significant predictors of oocyte yield. Multivariate analysis confirmed no significant relationship between AFC or AMH, whilst on univariate analysis statistical significance was proven. 36 women returned to use their oocytes, with 41 autologous egg thaw cycles undertaken. 12 successful livebirths were achieved by 11 women. The overall livebirth rate was 26.8% per cycle. No livebirths occurred in women [?]40 years old and 82% of all livebirths were in women aged 36-39 at freeze. Conclusions: This study demonstrates clinical, biochemical and radiological markers can predict oocyte yield in SEF cycles. However, subsequent reproductive outcomes highlight women embarking upon SEF should be encouraged to do so before the age of 37 years, and no later than 40 to optimise successful livebirth.

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Section: Discussionmentioning

confidence: 71%

Analysis of ten years of social oocyte cryopreservation: a research article

Kasaven¹,

Jones²,

Heath³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…AMH is considered a reliable predictor of oocyte yield [ 17 ]. However, it is well reported that levels are strongly correlated with age [ 18 ]. Although this study demonstrates AMH was a statistically significant predictor of yield from univariate analysis, there was no significant relationship when controlling for confounding variables with multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Reproductive outcomes from ten years of elective oocyte cryopreservation

Kasaven

Jones

Heath

et al. 2022

Arch Gynecol Obstet

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Research question To assess the relationship between the number of oocytes retrieved during elective oocyte cryopreservation (EOC) cycles with various clinical, biochemical, and radiological markers, including age, body mass index (BMI), baseline anti-Müllerian hormone (AMH), antral follicle count (AFC), Oestradiol level (E2) and total number of follicles ≥ 12 mm on the day of trigger. To also report the reproductive outcomes from women who underwent EOC. Methods A retrospective cohort of 373 women embarking on EOC and autologous oocyte thaw cycles between 2008 and 2018 from a single London clinic in the United Kingdom. Results 483 stimulation cycles were undertaken amongst 373 women. The median (range) age at cryopreservation was 38 (26–47) years old. The median numbers of oocytes retrieved per cycle was 8 (0–37) and the median total oocytes cryopreserved per woman was 8 (0–45). BMI, E2 level and number of follicles ≥ 12 mm at trigger were all significant predictors of oocyte yield. Multivariate analysis confirmed there was no significant relationship between AFC or AMH, whilst on univariate analysis statistical significance was proven. Thirty six women returned to use their cryopreserved oocytes, of which there were 41 autologous oocyte thaw cycles undertaken. There were 12 successful livebirths achieved by 11 women. The overall livebirth rate was 26.8% per cycle. No livebirths were achieved in women who underwent EOC ≥ 40 years old, and 82% of all livebirths were achieved in women who had done so between 36 and 39 years old. Conclusion Clinical, biochemical and radiological markers can predict oocyte yield in EOC cycles. Reproductive outcomes are more favourable when cryopreservation is performed before the age of 36, with lower success rates of livebirth observed in women aged 40 years and above.

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“…It is well known that the prognosis of IUI cycles is inferior compared to that of non-male factor couples because of the lower quality and quantity of inseminated spermatozoa. 16 Moreau et al 6 evaluated the livebirth rate after four IUI cycles in a retrospective study. They concluded that age-specific levels of AMH were not associated with the cumulative livebirth rate irrespective of age groups; a 9%-12% birth rate after four IUI was observed in women with low AMH.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve

Kaleli

Kervancıoğlu

Erol

et al. 2022

Intl J Gynecology & Obste

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Objective To assess the efficacy of ovulation induction and intrauterine insemination (IUI) in couples with diminished ovarian reserve (DOR). Methods Women aged 20–39 years and men younger than 50 years were included. Four “ovarian reserve groups” were created according to anti‐Müllerian hormone (AMH) and the partner's age. Gestational sac finding on ultrasound examination was the primary outcome measure. Results The study was carried out on a total of 770 cycles of 362 women in an infertility cohort that consisted of 75 women with DOR treated by 153 cycles and 287 women without DOR treated by 617 cycles. The pregnancy rate was similar in the four ovarian reserve groups in terms of first, second, third plus fourth, and total attempts of IUI cycles. Moreover, the pregnancy rate, miscarriage rate, and multiple pregnancy rate were similar. We found no difference in the cumulative pregnancy rate among the groups after four IUI cycles. Multivariate logistic regression analysis of the entire cohort revealed that infertility duration, post‐wash sperm count, and follicle number greater than 11 mm on the day of human chorionic gonadotropin trigger were independent predictors of pregnancy (P < 0.001). Neither age nor AMH predicted pregnancy after ovulation stimulation and IUI. Conclusions Ovulation stimulation and IUI are equally effective in women with DOR and in women with normal ovarian reserve in terms of pregnancy rate, multiple pregnancy rate, and miscarriage rate per IUI cycle or cumulative pregnancy rate after four cycles of IUI.

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Age-specific anti-Mullerian hormone (AMH) levels poorly affects cumulative live birth rate after intra-uterine insemination

Cited by 11 publications

References 44 publications

Analysis of ten years of social oocyte cryopreservation: a research article

Analysis of ten years of social oocyte cryopreservation: a research article

Reproductive outcomes from ten years of elective oocyte cryopreservation

Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve

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