Analysis of ten years of social oocyte cryopreservation: a research article

Abstract

Objective: To assess the relationship between number of oocytes retrieved during social egg freezing (SEF) cycles with various clinical, biochemical and radiological markers; e.g. age, body mass index (BMI), baseline anti-Mullerian hormone (AMH), antral follicle count (AFC), Oestradiol level (E2) and total number of follicles [?]12mm at trigger. Main outcome measures: To describe the characteristics and outcomes of women who underwent SEF. Methods: A retrospective cohort of women embarking on SEF between 2008 and 2018 from a single London UK fertility clinic. Results: 483 stimulation cycles were undertaken in 373 women. The median age at freeze was 38 (26-47) years. The median numbers of oocytes retrieved per cycle was 8 (0-37), and total oocytes cryopreserved 8 (0-45) per woman. BMI, E2 level and number of follicles [?]12mm at trigger were all significant predictors of oocyte yield. Multivariate analysis confirmed no significant relationship between AFC or AMH, whilst on univariate analysis statistical significance was proven. 36 women returned to use their oocytes, with 41 autologous egg thaw cycles undertaken. 12 successful livebirths were achieved by 11 women. The overall livebirth rate was 26.8% per cycle. No livebirths occurred in women [?]40 years old and 82% of all livebirths were in women aged 36-39 at freeze. Conclusions: This study demonstrates clinical, biochemical and radiological markers can predict oocyte yield in SEF cycles. However, subsequent reproductive outcomes highlight women embarking upon SEF should be encouraged to do so before the age of 37 years, and no later than 40 to optimise successful livebirth.

Age-related fertility decline: is there a role for elective ovarian tissue cryopreservation?

“…As the process is still novel, only 3.1–12.1% of women who have undergone the procedure have since returned to use their cryopreserved oocytes ( Ben-Rafael, 2018 ; Cobo et al , 2018 ; Gürtin et al , 2019 ; Kasaven et al , 2020 ). Consequently, successful LBRs of 17.5–30.5% have been observed in such women ( Gürtin et al , 2019 ; Kasaven et al , 2020 ), highlighting that EOC is a feasible method of fertility preservation for ARFD. The chances of successful livebirth are dependent on two factors; age at the time of cryopreservation and the number of oocytes retrieved.…”

Advanced Maternal Age Deteriorates the Developmental Competence of Vitrified Oocytes in Mice

“…Single women who do not want to conceive can postpone childbearing by cryopreserving oocytes. It was reported that an increasing number of women pursue oocyte cryopreservation [ 5 ] and the median age of these women is 38 years [ 6 , 7 ]. Of note, more than half the women who undergo oocyte cryopreservation are older than 37 years.…”