Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study

Liu, Junjie; Dai, Yanpeng; Yuan, Enwu; Li, Yushan; Wang, Quanxian; Wang, Linkai; Su, Yanhua

doi:10.1136/bmjopen-2019-030201

Cited by 6 publications

(9 citation statements)

References 34 publications

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“…The 95% CIs were calculated for each analyte and provided as a measure of the uncertainty of the RI estimation (Figures S3-S6 showed graphical representations of the estimated models of each analyte). A comparison between the indirect RIs in our cohort to those reported in the literature as direct measures in paediatric studies [20][21][22][23][24][25][26] is reported in Table S7. For all analytes except TG, the estimated RIs (both lower and upper limits) were in good agreement with those published.…”

Section: Resultsmentioning

confidence: 99%

Plasma lipids paediatric reference intervals: Indirect estimation using a large 14‐year database

Galozzi,

Padoan,

Moretti

et al. 2024

J. pediatr. gastroenterol. nutr.

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ObjectivesEstablishing direct reference intervals (RIs) for paediatric patients is a very challenging endeavour. Indirect RIs can address this problem, using existing clinical laboratory databases from real‐world data research. Compared to the traditional direct method, the indirect approach is highly practical, widely applicable, and low‐cost. Considering the relevance of dyslipidemia in the paediatric age, to provide better laboratory services to the local paediatric population, we established population‐specific lipid RIs via data mining.MethodsOur laboratory information system was searched for cholesterol (TC), triglycerides (TG), low‐density lipoprotein (LDL) and high‐density lipoprotein (HDL) of patients aged less than 18 years, performed from January 2009 until December 2022. RIs were estimated using RefineR algorithm.ResultsValues from 215,594 patients were initially collected. After refining data on the basis of specific exclusion criteria that left 17,933 patients, we determined the RIs for each analyte, including corresponding 95% confidence interval (95% CI). Age and sex partitions were required for proper stratification of the heterogenous subpopulations. Age‐related variations in TC and TG values were observed mainly in children until 5 years. RIs were defined for children less than 3 years and for those of 3–18 years. In our population, the obtained RIs were comparable with those of the literature, but the upper TG limit in subjects under the age of 3 (2.03 mmol/L with 95% CI: 1.45–2.86) was lower than that previously reported.ConclusionsOur RIs, necessary for paediatric lipid monitoring, are tailored to the serviced patient population as should be done whenever possible.

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Section: Resultsmentioning

confidence: 99%

Plasma lipids paediatric reference intervals: Indirect estimation using a large 14‐year database

Galozzi,

Padoan,

Moretti

et al. 2024

J. pediatr. gastroenterol. nutr.

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“…In comparison with the study that was conducted in Birjand, a city in the east of Iran, LDL in both genders and TC in girls was higher compared to LDL and TC values in the current study, but HDL and TG were lower in the Birjand study compared to our study. Tese diferences between diferent regions of Iran may be due to dietary regimen, physical activity, hormonal status, environmental factors, and socioeconomic status, which can infuence the lipid profle in children [33,34] so that it is vital to provide age-and gender-specifc reference intervals using a local population [1].…”

Section: Discussionmentioning

confidence: 99%

“…Childhood dyslipidemia is considered a major worldwide health issue. Tis condition is positively correlated with a higher risk for cardiovascular disease (CVD), metabolic syndrome [1], and obesity [2], and when tracked into adulthood [3], consequently results in a higher rate of mortality [1].…”

Section: Introductionmentioning

confidence: 99%

Age-, Sex-, and Puberty-Associated Reference Intervals for Lipid Profile in Iranian Children and Adolescents

Montazeri‐Najafabady

Dabbaghmanesh

Asmarian

et al. 2023

International Journal of Endocrinology

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Childhood dyslipidemia is considered a major worldwide health issue. Identification of children with dyslipidemia is notably essential for healthcare providers in establishing and releasing recommendations for the management and prevention of future CVD. In the present study, we provided reference values for the lipid profile from Kawar (a city in the south of Iran) cohort of healthy children and adolescents aged 9–18 years. 472 subjects (234 girls and 238 boys) contributed to the current prospective cohort study using a systematic random sample stratified by age. Fasting lipid levels were measured by enzymatic reagents. Dual-energyX-ray absorptiometry (DEXA) was used to evaluate puberty based on the Tanner stages. LMS Chart Maker and Excel software were used to construct the gender-specific reference plots showing the 3, 10, 25, 50, 75, 90, and 97th percentiles of BMI, cholesterol, TG, HDL, TC, LDL, and non-HDL. The outcomes revealed that concentrations of TC, LDL, and non-HDL were drastically greater in girls as compared to boys. TG increased with age in both genders, while HDL, TC, LDL, and non-HDL declined. We also observed that puberty was associated with higher lipid values in boys and girls except for TG in boys. Our study prepared age- and sex-specific reference intervals for the lipid profile in Iranian children and adolescents. Converted to age and gender percentiles, these reference intervals are expected to serve as an effective and consistent tool for doctors to identify dyslipidemia among children and adolescents.

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“…Even from the perspective of a patient, it sets in ease and augment convenience for the laboratory services. 9,27 This may lead to more increased compliance from patients and could usher in newer future research to modify and better the norms improving the practice, thus making health care availability more convenient by rendering it more accessible and affordable.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Novelty in Lipid Profiling of Patients: A Non-fasting Approach from Eastern India

et al. 2022

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Objective To date, no reference interval is available for lipid profile, including total cholesterol (TC), triglycerides (TGs), high-density lipoprotein (HDL), or low-density lipoprotein (LDL)-cholesterol, etc., in a non-fasting state. Hence, the study was taken up with the objective of exploring the possibility of establishing a reference interval for non-fasting lipid profile consisting of serum TC, TG, LDL, HDL, and very low-density lipoprotein (VLDL) cholesterol. Materials and Methods A total of 1,350 apparently healthy subjects, including 636 healthy men and 714 healthy women of 18 years and beyond of age, were enrolled in the study. Reference individuals were recruited using cluster sampling method from various villages and semi-urban regions irrespective of their sex, religion, socioeconomic status, or any other demographic profile, and samples were analyzed in Beckman Coulter AU480 analyzer. Results The mean age of 1,350 participants was 38.23 ± 15.94 years. We found that all the test parameters require a different reference interval than the established fasting reference range, except for HDL cholesterol in females. The data were subdivided into subjects below 40 years, between 40 and 60 years, and older than 60 years of age. All five parameters in the lipid profile were individually analyzed and were compared age group-wise and gender-wise with the total study population. Significant differences in the various dataset were found. Conclusion A shift toward non-fasting lipid interval measurement is, thus, a piece of evidence-driven mechanism. Even from a patient's perspective, it sets in ease and convenience in lipid-profile testing, subsequently leading to a more compliant cardiovascular management and monitoring.

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Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study

Cited by 6 publications

References 34 publications

Plasma lipids paediatric reference intervals: Indirect estimation using a large 14‐year database

Plasma lipids paediatric reference intervals: Indirect estimation using a large 14‐year database

Age-, Sex-, and Puberty-Associated Reference Intervals for Lipid Profile in Iranian Children and Adolescents

Exploring the Novelty in Lipid Profiling of Patients: A Non-fasting Approach from Eastern India

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