Age representation in antiepileptic drug trials: A systematic review and meta-analysis

Desmarais, Philippe; C, Miville; Milán-Tomás, Ángela; Nguyên, Quôc Dinh; Ojeda-López, Carmen; Masellis, Mario; Black, Sandra E.; Andrade, Danielle M.; Herrmann, Nathan

doi:10.1016/j.eplepsyres.2018.03.005

Cited by 6 publications

(12 citation statements)

References 27 publications

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“…In this study, the most frequently used outcome designating missing inclusion of older adults is age as exclusion criterion. The tendency to use age limit as an exclusion criterion has been slightly decreasing over time, 16,20 but a trend for increasing mean age in clinical studies has not so far been observed 14,17 . Since 1993, international guidelines have recommended not to exclude persons only based on an age limit 17 .…”

Section: Discussionmentioning

confidence: 99%

“…A study on missing inclusion of older adults in CTs concerning antiepileptic medication, examined how different exclusion criteria affected the average age in a study population. The only exclusion criterion that lowered average age in a population was found to be patients with neurological conditions 16 . Despite investigator presumptions, this was not the case for other exclusion criteria, for example age limit, comorbidity, lesser functional abilities and organ dysfunction.…”

Section: Methodsmentioning

confidence: 96%

“…Desmaris et al 16 :44% of the identified studies use age as an exclusion criterion. 60% of studies uses comorbidities as exclusion criteria which are suspected of disproportionately exclude the older adults.…”

Section: Methodsmentioning

confidence: 99%

“…Five high‐quality papers calculated the percentage of studies using age limit as an exclusion criterion 5,14‐17 . This percentage ranged from 10% to 44%.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 7 papers quantified and/or discussed the proportion of studies using exclusion criteria that might exclude older adults from CTs. 44% to 83% of studies used exclusion criteria that might disproportionally exclude older adults 5,15‐19,21 . A study on missing inclusion of older adults in CTs concerning antiepileptic medication, examined how different exclusion criteria affected the average age in a study population.…”

Section: Methodsmentioning

confidence: 99%

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Are older adults insufficiently included in clinical trials?—An umbrella review

Florisson

Aagesen

Bertelsen

et al. 2020

Basic Clin Pharma Tox

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Older adults are the most rapidly increasing age group globally. 1 55% to 95% of older adults are categorized as multimorbid, and the prevalence is increasing with age. 2 Thus, older adults tend to receive more medical treatment compared to younger people. 3 Treatment guidelines are primarily based on data from randomized clinical trials (RCTs) 4 that tend to some extent to exclude older adults. The insufficient inclusion of older adults is reflected by a lower external validity in RCTs, where the average age, level of function, comorbidities and number of prescribed drugs do not reflect the target population. 5 Using data from RCTs not including older adults sufficiently is problematic since the age-related physiological changes are not taken into account. 6 For instance,

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

“…Five high‐quality papers calculated the percentage of studies using age limit as an exclusion criterion 5,14‐17 . This percentage ranged from 10% to 44%.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations