Age-related progression of arterial stiffness and its elevated positive association with blood pressure in healthy people

High serum uric acid is associated with increased cardio-ankle vascular index (CAVI) in healthy Japanese subjects: A cross-sectional study

“…Therefore, the validity of PWV in reflecting actual arterial stiffness is questionable, and this parameter is unsuitable to evaluate the effect of antihypertensive drugs in the arterial wall. On the other hands, CAVI is independent of BP, which makes it more precise and reproducible than PWV, whereas its predictive value of cardiovascular events is not established enough [28,29]. The prospective study to examine the benefit of using CAVI as a predictive indicator of cardiovascular events is needed.…”

Cardio-Ankle Vascular Index is Independently Associated with Future Cardiovascular Events in Outpatients with Metabolic Disorders

“…Therefore, the validity of PWV in reflecting actual arterial stiffness is questionable, and this parameter is unsuitable for evaluating the effect of antihypertensive drugs in the arterial wall. On the other hand, CAVI is independent of BP, which makes it more precise and reproducible than PWV, whereas its predictive value of cardiovascular events is not established enough 20,36) . Furthermore, Izuhara et al 37) reported the multiple logistic analysis revealing that CAVI, but not baPWV, was associated with the presence of carotid and coronary arteriosclerosis.…”

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

“…Outstanding aspects of age-associated changes in vasculature include intima and media thickening increased arterial stiffness and dilation of central elastic arteries resulting in a reduced ability to expand and contract in response to pressure variations (Kotsis et al, 2011). Numerous data have highlighted a linear relationship between arterial stiffness and age (Wen et al, 2015). Arterial stiffness is linked to endothelial dysfunction as suggested by the impairment of endothelial vasodilation that always precedes arterial stiffness (Scuteri et al, 2008).…”