Age-related ocular vascular changes

Abstract

These results compel a need for further investigation of age-related changes in ocular physiology and pathophysiology.

Characteristics of open globe injuries in geriatric patients

“…By 2030, this is expected to increase to almost 1 billion (11.7%). [13] A majority of the estimated 40 million blind individuals around the world are in the older age groups. Data on blindness and visual impairment are obtained primarily from blindness registries and prevalence surveys in different countries throughout the world.…”

“…The retinal blood supply decreases in elderly subjects, and further implies a net increase in the resistance of the vascular bed and/ or decrease in the total functional vessel diameter. [13] In addition, visual function changes include declining visual acuity and diminished visual field sensitivity. As a result of these changes, globe rigidity decreases and eye injuries can occur even after a mild trauma in the elderly population.…”

The effect of ageing on the ocular surface parameters

“…Furthermore, the corneal sensitivity is reduced, epithelial and endothelial basement membranes increase its thickness, the number of keratocytes decrease [8] and there is an increased loss of corneal endothelial cells [9]. The incidence and prevalence of ocular diseases as age-related maculopathy, liquefaction of the vitreous, glaucoma, vascular occlusive diseases, cataract and dry eye increase significantly with age [10,11].…”

Mirtogenol® potentiates latanoprost in lowering intraocular pressure and improves ocular blood flow in asymptomatic subjects

“…5 Pycnogenol was shown in human pharmacologic studies to improve endothelial function. 6 Mirtoselect was shown to counteract hyperpermeability of ciliary capillaries, initiated by paracentesis, as measured by the Evans Blue concentration in the aqueous humor.…”