The effect of ageing on the ocular surface parameters

Rico-del-Viejo, Laura; Lorente‐Velázquez, Amalia; Hernández-Verdejo, José Luis; García-Mata, Ricardo; Benítez-del-Castillo, J.M.; Madrid-Costa, David

doi:10.1016/j.clae.2017.09.015

Cited by 23 publications

(21 citation statements)

References 53 publications

(68 reference statements)

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“…These results emphasize the influence of ageing in the MG morphology but also in several ocular surface parameters such as corneal staining, LLT or tear volume among others. [27,42] This has been previously reported [27] The Ocular-surface-disease-index; SPEED: Standard Patient Evaluation of Eye Dryness; TFO: tear film osmolarity; TMHk: tear meniscus height; Bulbar and limbal redness were graded automatically by K5M software; NIKBUT-FR: first rupture non-invasive Keratograph tear film break-up time; NIKBUT-AVG: average of non-invasive Keratograph tear film break-up time. Table 3.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, it is not possible to ascertain if these signs in ocular surface parameters are due to MGL or to age. Indeed, the great influence of aging on MG morphology and function is well-known and documented in the literature [7,18,27,39]. In order to address this point, the relationship between MGL and the ocular surface parameters was assessed considering age as a covariant.…”

Section: Discussionmentioning

confidence: 99%

“…[7] On the other hand, in a previous study it has been observed that several ocular surface parameters such as ocular redness, corneal and conjunctival staining are highly influenced by ageing. [27] As well, TFOS DEWS II recently underlined that clinical DED signs increase in a higher amount by decade compared with symptoms. [2] These findings highlight the role of age in both MGL and ocular surface parameters.…”

Section: Submission Files Included In This Pdfmentioning

confidence: 99%

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The influence of meibomian gland loss on ocular surface clinical parameters

Rico-del-Viejo

Benítez-del-Castillo²,

Gómez-Sanz

et al. 2019

Contact Lens and Anterior Eye

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Purpose: To assess the relationship between the meibomian gland loss (MGL) and relevant ocular surface clinical parameters and the influence of age in its relationship. Methods: A total of 161 participants (mean age; 42±17 years) were enrolled in this study. Infrared meibography was performed using Keratograph 5M (K5M; Oculus GmbH, Wetzlar). Participants were divided into five groups according to total meiboscore and the ocular surface parameters of each MGL group were studied. In addition, the relationship between MGL and the ocular surface parameters was established including age as covariant. Results: Both eyelids were taken into account since no association between the MGL from upper and lower eyelid was found (k value=0.2; p=0.3) despite they were significantly correlated (r= 0.3; p<0.001). No statistically significant differences were found in symptomatology among different MGL groups. Statistically significant differences were found among MGL groups in tear osmolarity (p=0.02), bulbar redness (p=0.04), corneal and conjunctival staining (p=0.01 and p=0.004, respectively). Despite it, only corneal staining showed a significant correlation with MGL when age was covariant (r=0.2; p=0.04). Conclusions: MGL higher than 50% seems to be accompanied by signs on the ocular surface. Furthermore, age demonstrated to be a relevant factor when assessing the MGL. For this reason, future studies should compare matched-age groups in order to know the contribution of the MGL on the ocular surface and establish valid cutoff values for dry eye diagnosis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Submission Files Included In This Pdfmentioning

confidence: 99%

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The influence of meibomian gland loss on ocular surface clinical parameters

Rico-del-Viejo

Benítez-del-Castillo²,

Gómez-Sanz

et al. 2019

Contact Lens and Anterior Eye

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“…In ocular surface of the eye, the tear fluid, consisting of lipid, aqueous and mucin layers, which are produced respectively by meibomian glands, lacrimal glands and conjunctival goblet cells, is known to be altered during aging in many ways. Increased age results in lowered tear film stability and lacrimal gland secretion [3–9]. Tear film composition is also altered [10], similar to meibomian gland-produced lipid profiles [7, 11], while tear evaporation rate is elevated [12].…”

Section: Introductionmentioning

confidence: 99%

Age-associated changes in human tear proteome

et al. 2019

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Background Prevalence of many eye and ocular surface diseases increases with age. While the clinical characteristics and pathophysiologic mechanisms of these conditions are often either known or extensively studied, the effects of normal aging on tear film and ocular surface have not been as widely researched. Methods In order to examine the effects of aging on tear fluid proteomics, tear fluid samples were collected preoperatively from 115 subjects undergoing strabismus or refractive surgery using glass microcapillary tubes. In addition to their refractive error or strabismus, the subjects did not have any other current, known eye diseases. The non-pooled samples were analysed using NanoLC-TripleTOF implementing a sequential window acquisition of all theoretical fragment ion spectra mass spectrometry, resulting in quantified data of 849 proteins. Results According to correlation results, 17 tear proteins correlated significantly with increased age and many of these proteins were connected to inflammation, immune response and cell death. According to enrichment analysis, growth and survival of cells decreased while immune response and inflammation increased with aging. We also discovered several well-known, activated and inhibited upstream regulators, e.g. NF-κB, which has been previously connected to aging in numerous previous studies. Conclusions Overall, the results show the common age-dependent alterations in tear fluid protein profile, which demonstrate similar age-associated alterations of biological functions previously shown in other tissue and sample types. Electronic supplementary material The online version of this article (10.1186/s12014-019-9233-5) contains supplementary material, which is available to authorized users.

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“…Dynamic models of optical changes in the human eye based on OSI values explain changes in vision due to tear film changes in normal eyes [14] and dry eyes [16, 35, 36]. It would be relevant to study this in the presbyopic population, which has poorer tear film stability when compared to the younger population [37] and needs more complex multifocal CL designs.…”

Section: Discussionmentioning

confidence: 99%

Effects of Blink Rate on Tear Film Optical Quality Dynamics with Different Soft Contact Lenses

García-Montero

Rico-del-Viejo

Martínez-Alberquilla

et al. 2019

Journal of Ophthalmology

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Objective. The aim of this study was to investigate tear film optical quality dynamics for four types of silicone hydrogel contact lenses (SHCLs) for daily wear over a 15-day period and for different blink rate (BR) patterns. Methods. A prospective randomized, double-blind, cross-over pilot study including four SHCLs (A: lotrafilcon B (Air Optix plus HydraGlyde, Alcon Laboratories); B: samfilcon A (Ultra, Bausch & Lomb); C: comfilcon A (Biofinity, CooperVision); and D: filcom V3 (Blu:gen, Mark’Ennovy)). Serial measurements of Objective Scatter Index (OSI) using the HD Analyzer (Visiometrics S.L., Terrassa, Spain) were taken at different blinking patterns: blinking every 2.5 seconds (high BRs) and every 9 seconds (low BRs). They were performed during the first visit before CL insertion (baseline), after 20 minutes of CL wear (Day 1), and during the last visit after 8 hours of CL wear on day 15 of use (Day 15). Results. Normal young healthy subjects were recruited and fitted with the four lenses. For low BRs, the mean OSI value increased over time for all CLs and the slope of the curve also increased for all CLs, except for CL D. However, for high BRs, the mean OSI value increased only for CLs B and C and the slope of the curve did not change over time for any of them. Conclusions. These results suggest that the tear film optical quality dynamics after wearing SCHLs for 15 days seems to undergo a slight deterioration only for lowest BR.

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The effect of ageing on the ocular surface parameters

Abstract: Abstract:Purpose: To assess the changes on the ocular surface parameters with ageing. Methods Conclusions:These results suggest that the ocular surface conditions change with ageing. Many of these ocular surface parameters could be relevant for contact lens fitting.

Cited by 23 publications

References 53 publications

The influence of meibomian gland loss on ocular surface clinical parameters

The influence of meibomian gland loss on ocular surface clinical parameters

Age-associated changes in human tear proteome

Effects of Blink Rate on Tear Film Optical Quality Dynamics with Different Soft Contact Lenses

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