Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease

Tong, Zhiqian; Han, Chanshuai; Qiang, Min; Wang, Weishan; Lv, Jihui; Zhang, Shouzi; Luo, Wei; Li, Hui; Liu, Hongjun; Zhou, Jiang‐Ning; Wu, Beibei; Su, Tao; Yang, Xu; Wang, Xiaomin; Liu, Ying; He, Rong

doi:10.1016/j.neurobiolaging.2014.07.018

Cited by 87 publications

(60 citation statements)

References 67 publications

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“…Documentary evidence indicates that a direct intracerebroventricular injection of excess FA into animal models causes central nervous system damage and, in particular, a marked impairment in memory [13–16]. These data strongly support the notion that excess FA in the hippocampus leads to cognitive deficits.…”

Section: Introductionmentioning

confidence: 57%

A Sensitive and Rapid Method for Detecting Formaldehyde in Brain Tissues

Yue

Zhang²,

Wen³

et al. 2017

Analytical Cellular Pathology

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The existing methods for detecting formaldehyde (FA) in brain samples are expensive and require sophisticated experimental procedures. Here, we established a highly sensitive and selective spectrophotometric method, which is based on a reaction in which FA reacts with colorless reagent 4-amino-3-penten-2-one (Fluoral-P) to produce a yellow compound, 3,5-diacetyl-1,4-dihydrolutidine (DDL), which can be detected by a spectrophotometer at 420 nm at room temperature. The sensitive response time point was found to be at the first hour, and the optimal pH of derivative reaction was pH 6.0. The limit of detection (LOD) and the limits of quantization (LOQ) for detecting FA were 0.5 μM and 2.5 μM, respectively. Using this method, an abnormally high level of FA was detected in both the brains of FA-injected mice and autopsy hippocampus tissues from patients with Alzheimer's disease. This finding suggests that the modified Fluoral-P method is effective for measuring levels of FA in the brains.

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Section: Introductionmentioning

confidence: 57%

A Sensitive and Rapid Method for Detecting Formaldehyde in Brain Tissues

Yue

Zhang²,

Wen³

et al. 2017

Analytical Cellular Pathology

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“…During aging, a decrease in global hippocampal 5-mC level [32] and an increase in 5hmC content have been observed in hippocampus [33]. Consistently, a wide global DNA demethylation associated with an abnormal high level of formaldehyde was found in autopsy samples from AD patients [34][35][36]. 2) Tumor.…”

Section: Exogenous and Endogenous Factors Induce Formaldehyde Accumulmentioning

confidence: 73%

Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?

Tong¹

2017

J Alzheimers Dis Parkinsonism

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“…Long-term FA inhalation is thought to induce MCS or SBS (Malek et al, 2003;Pitten et al, 2000;Sorg et al, 1998Sorg et al, , 2001Sorg et al, , 2004 and damage to the central nervous system (Ahmed et al, 2007;Aslan et al, 2006;Tang et al, 2013a;Tong et al, 2013aTong et al, , 2015. We tested potential miRNA changes caused by FA inhalation in order to understand the molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Formaldehyde exposure alters miRNA expression profiles in the olfactory bulb

Yang

Shao

2015

Inhalation Toxicology

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It has been reported that inhaling formaldehyde (FA) causes damage to the central nervous system. However, it is unclear whether FA can disturb the function of the olfactory bulb. Using a microarray, we found that FA inhalation altered the miRNA expression profile. Functional enrichment analysis of the predicted targets of the changed miRNA showed that the enrichment canonical pathways and networks associated with cancer and transcriptional regulation. FA exposure disrupts miRNA expression profiles within the olfactory bulb.

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Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease

Cited by 87 publications

References 67 publications

A Sensitive and Rapid Method for Detecting Formaldehyde in Brain Tissues

A Sensitive and Rapid Method for Detecting Formaldehyde in Brain Tissues

Urine Formaldehyde: A Non-Invasive Marker for Alzheimer’s Disease?

Formaldehyde exposure alters miRNA expression profiles in the olfactory bulb

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