2016
DOI: 10.1590/2359-3997000000215
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Abstract: Objective: To compare serum anti-Müllerian hormone (AMH) and other endocrine parameters between patients diagnosed with polycystic ovary syndrome (PCOS) and age-matched ovulatory women. Materials and methods: AMH, DHEAS, FSH, LH, PRL, TSH and total testosterone (TT) were prospectively measured in oligo-ovulatory PCOS patients (n = 595) and in ovulatory non-PCOS women (n = 157) referred to a tertiary infertility center. Mean BMI was similar across the two study populations and there were no smokers in the sampl… Show more

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Cited by 12 publications
(9 citation statements)
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References 22 publications
(29 reference statements)
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“…Given that low SHBG concentrations are associated with insulin resistance ( 27 ), the elevated DHEA-S concentrations could reflect an adaptive mechanism to this metabolic disturbance, implying further complexity in the interplay between hormones and energy homeostasis ( 28 ). Furthermore, the negative correlation between adrenal androgens with age demonstrated in the present study is in accordance with previous findings of an age-related reduction in DHEA-S concentrations in the general population ( 29 ) as well as in women with PCOS ( 30 ).…”
Section: Discussionsupporting
confidence: 93%
“…Given that low SHBG concentrations are associated with insulin resistance ( 27 ), the elevated DHEA-S concentrations could reflect an adaptive mechanism to this metabolic disturbance, implying further complexity in the interplay between hormones and energy homeostasis ( 28 ). Furthermore, the negative correlation between adrenal androgens with age demonstrated in the present study is in accordance with previous findings of an age-related reduction in DHEA-S concentrations in the general population ( 29 ) as well as in women with PCOS ( 30 ).…”
Section: Discussionsupporting
confidence: 93%
“…In PCOS women, testosterone decreased in 20%, from 20 to 24 year strata, what is not different from the decrease of 25% reported in a longitudinal study including women between 22 years and 43 years of age (5). In general, without normalization, a decline in testosterone levels in PCOS patients ranging from 20 and 50% have been reported, markedly after 30 years of age (3,5,6,8,16,18,19,21,24,66,67,68). This fact shows that the biochemical hyperandrogenism, as a parameter to diagnose PCOS, becomes weak with age and may hamper the diagnosis of PCOS after 30 years of age.…”
Section: Discussionmentioning
confidence: 51%
“…This fact shows that the biochemical hyperandrogenism, as a parameter to diagnose PCOS, becomes weak with age and may hamper the diagnosis of PCOS after 30 years of age. Despite these findings, two prospective studies did not show significant changes in testosterone levels in PCOS women with advancing age (67,69). In addition, a small number of cross-sectional studies also did not report any decrease in testosterone 9:2 levels in PCOS women either younger or older than 30 years (70,71).…”
Section: Discussionmentioning
confidence: 85%
“…Additionally, the role of age in determining normal ranges for AMH levels has been overlooked in the PCOS literature despite a clearly established decline in AMH over the lifespan in large cohorts of normal women . While several recent publications have depicted AMH values by age group in controls and patients with PCOS, no statistical analysis proposing age‐specific thresholds for distinguishing between groups was been performed, thereby limiting clinical utility . In providing age category‐stratified thresholds of AMH, we acknowledge the inverse relationship between serum AMH concentration and chronologic age.…”
Section: Discussionmentioning
confidence: 99%