Age-related distribution of longitudinal pre-strain in abdominal aorta with emphasis on forensic application

Horny, Lukas; Adámek, Tomáš; Vesely, Jan; Chlup, Hynek; Žitný, Rudolf; Konvickova, S.

doi:10.1016/j.forsciint.2011.07.007

Cited by 16 publications

(18 citation statements)

References 30 publications

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“…This study extends our previous observations reported in [22,23]. Therefore, only basic information necessary to avoid misunderstandings will be repeated here.…”

Section: Methodssupporting

confidence: 83%

“…It was shown in our previous studies that the magnitude of the longitudinal prestrain (the ratio between the in situ length and the ex situ length of the aortic segment) and the diameter of the abdominal aorta correlate significantly with chronological age [22,23]. However, these relationships have been found to be best fitted with the power law model.…”

Section: Introductionmentioning

confidence: 83%

“…Moreover, CAI yields more accurate results (the 95% prediction intervals in the power law models employed in [22] yielded ranges of 30.5-62.3 and 25.3-57.0 years for the mean prestrain in the female population and in the male population, respectively). [22,23]. This result is replicated in the CAI method (correlation coefficient R00.148/0.024 female/male).…”

Section: Comparison With Existing Methodsmentioning

confidence: 99%

“…Unfortunately, we are not able to measure the diameter in situ with desirable accuracy. It is also not clear whether the area ratio depends linearly on age since the prestrain, which is a dimensionless deformation measure, depends nonlinearly on age [22,23]. Finally, it should be noted that this was a somewhat simplified interpretation, since the cylindrical geometry of an artery is also prestrained in the circumferential direction (this strain is usually called "residual" and is manifested when a radial cut of an arterial ring is made as an abrupt opening to a sector [30,31]).…”

Section: Biomechanicsmentioning

confidence: 99%

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Age estimation based on a combined arteriosclerotic index

et al. 2011

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This study introduces a new quantity, the combined arteriosclerotic index (CAI), which is defined as the ratio between the diameter and the longitudinal prestrain of an artery. The longitudinal prestrain has been adopted as the ratio between the in situ length and the excised length of the abdominal aorta, and is a measure of arterial elasticity. During ageing, arteriosclerosis is manifested by the loss of pretension and by enlargement of the diameter of the artery. CAI combines these two effects. A sample of 61 female and 194 male autopsy measurements of human abdominal aortas shows that CAI correlates significantly with chronological age (R = 0.916/0.921; female/male). The sample had the following parameters: age 53 ± 19/48 ± 16 years; diameter of the abdominal aorta 12.4 ± 2.2/13.4 ± 2.1 mm; and longitudinal prestrain 1.13 ± 0.10/1.15 ± 0.10 (mean ± sample standard deviation; female/male). The resulting CAI was 11.2 ± 2.7/11.9 ± 2.6 mm. The classical linear regression model was employed for age estimation by CAI. The model gave a residual standard deviation of 7.6/6.3 years and a 95% prediction interval range of ± 15.4/12.5 years (female/male). A two-sample t-test confirmed that there are significant differences between the female and male population during ageing, reflected by CAI, unlike longitudinal prestrain. It was concluded that CAI is a suitable predictor of age at time of death and is easily obtainable in the autopsy room.

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“…This study extends our previous observations reported in [22,23]. Therefore, only basic information necessary to avoid misunderstandings will be repeated here.…”

Section: Methodssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 83%

Section: Comparison With Existing Methodsmentioning

confidence: 99%

Section: Biomechanicsmentioning

confidence: 99%

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Age estimation based on a combined arteriosclerotic index

et al. 2011

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“…In this paper, we continue with a study of the longitudinal mechanical behavior of human abdominal aorta, started with a detailed description of age-related changes in the longitudinal prestretch and its correlation with the diameter and with atherosclerosis described in [1,18,19].…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in longitudinal prestress in human abdominal aorta

2012

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Studies on the influence of aging on the longitudinal mechanical response of elastic arteries are rare, though longitudinal behavior may have a significant effect on pressure pulse transmission. Our study was designed to elucidate how aging is reflected in changes of the longitudinal prestress, prestretch and pretension force. The study involved ten human samples (six female, four male) of the abdominal aorta with longitudinal prestretch determined in autopsy. Cylindrical samples underwent a longitudinal elongation test in order to estimate the force necessary to attain the in situ length and to determine the corresponding axial prestress. The elastic modulus was estimated employing hyperelastic limiting chain extensibility model. It was found that pretension force, longitudinal prestress and prestretch are negatively correlated with age. The decreased longitudinal force necessary to obtain the in situ length suggested that the decrease in the prestress occurs not only due to the age-related increase in the crosssection area. Since elastin is the main constituent responsible for bearing the prestretch, this suggests that the observed decrease in the longitudinal prestress and prestretch reflects aging-induced damage to the elastin. Finally, constitutive modeling showed that limiting chain extensibility is a concept that is suitable for describing the aging effect.

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Towards non‐invasive in vivo characterization of the pathophysiological state and mechanical wall strength of the individual human AAA wall based on 4D ultrasound measurements

et al. 2018

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Abdominal aortic aneurysms (AAA) are a degenerative disease of the aorta with high associated mortality. Currently, there is a lack of in vivo information, which allows to characterise the individual aneurysmal wall with regard to wall strength or rupture risk. We have used 4D ultrasound strain imaging to compute the spatially resolved distribution of the in-plane strain tensor and of the local distensibility in three patient groups (young, < 40 y. o.; elderly, > 60 y. o.; AAA). Mean and local maximum deformation and distensibility as well as indices for the local variations of the strain and the distensibility distribution were determined. Mean distensibility is significantly decreasing from young (3.83 [2.83, 5.87] 10 −3 mmHg −1 ) to elderly (0.67 [0.39, 0.87] 10 −3 mmHg −1 ) and AAA (0.27 [0.20, 0.54] 10 −3 mmHg −1 ). Both indices characterising the heterogeneous elastic behaviour are significantly increasing from young through elderly to AAA. Linear dependency of some of the distensibility distribution indices on age and aortic diameter was observed in the young and elderly group.In contrast, none of the indices depended on age or maximum diameter in the AAA group. We hypothesize that the heterogeneous distensibility distribution is indicative of microstructural changes in the aortic and aneurysmal wall and might contribute to a more complete and informative pathophysiological characterisation of the AAA wall, either with respect to wall strength or rupture risk. To confirm this hypothesis, further studies will be necessary in which the correlation between the proposed indices and individual wall strength and rupture risk is tested. K E Y W O R D Sabdominal aortic aneurysm, in vivo, local distensibility, spatial heterogeneity INTRODUCTIONAn abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta, which is characterised by a permanent local dilatation of the aorta. AAA occur with a rate between 1.3% and 8.9% in men over 60 y.o. and 2.2% in women. [1,2] The main risk of this mostly asymptomatic disease is the rupture of the aneurysmal wall [3] with associated mortality rates of 53.1% in the US, 65.9% in the UK, [4] and 48% in men and 39% in women in Germany. [5] Currently, the clinical indications for surgical or endovascular treatment are a maximum AAA diameter larger than 5 cm in women and 5.5 cm in men or a growth rate of

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Age-related distribution of longitudinal pre-strain in abdominal aorta with emphasis on forensic application

Cited by 16 publications

References 30 publications

Age estimation based on a combined arteriosclerotic index

Age estimation based on a combined arteriosclerotic index

Age-related changes in longitudinal prestress in human abdominal aorta

Towards non‐invasive in vivo characterization of the pathophysiological state and mechanical wall strength of the individual human AAA wall based on 4D ultrasound measurements

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