Age-Related Differences of Neutrophil Activation in a Skeletal Muscle Ischemia–Reperfusion Model

Mowlavi, Arian; Reynolds, Christopher K.; Neumeister, Michael W.; Wilhelmi, Bradon J.; Song, Yao‐Hua; Naffziger, Ryan; Glatz, Frank R.; Russell, Robert C.

doi:10.1097/01.sap.0000041663.28703.54

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The Impact Of Aging On Organ Quality and Immunogenicity1

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“…In heart transplantation, an increased release of mitochondrial reactive oxygen species has been linked to the observed age-related differences [189]. Augmented age-related IR injuries have also been shown in experimental and clinical liver [190], kidney [191,192] and musculoskeletal studies [193,194]. …”

Section: The Impact Of Aging On Organ Quality and Immunogenicitymentioning

confidence: 99%

Immunosenescence and organ transplantation

Heinbokel¹,

Elkhal²,

Liu³

et al. 2013

Transplantation Reviews

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Increasing numbers of elderly transplant recipients and a growing demand for organs from older donors impose pressing challenges on transplantation medicine. Continuous and complex modifications of the immune system in parallel to aging have a major impact on transplant outcome and organ quality. Both, altered alloimmune responses and increased immunogenicity of organs present risk factors for inferior patient and graft survival. Moreover, a growing body of knowledge on age-dependent modifications of allorecognition and alloimmune responses may require age-adapted immunosuppression and organ allocation. Here, we summarize relevant aspects of immunosenescence and their possible clinical impact on organ transplantation.

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