Age-related differences in the pathogenesis of chronic rhinosinusitis

Cho, Seong H.; Hong, Seung Jae; Han, Brian; Lee, Sun H.; Suh, Lydia; Norton, James E.; Lin, David C.; Conley, David B.; Chandra, Rakesh; Kern, Robert C.; Tan, Bruce K.; Kato, Atsushi; Peters, Anju T.; Grammer, Leslie C.; Schleimer, Robert P.

doi:10.1016/j.jaci.2011.12.002

Cited by 68 publications

(75 citation statements)

References 9 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…S100A8/9 plays an important role in epithelial barrier function by providing epithelial repair and antimicrobial activities (10). We reported previously that levels of S100A8/9 in nasal lavage samples from patients with CRS were inversely correlated with increasing age (8). In this study, we extended this finding of the age-associated reduction of S100A8/9 to include nasal tissue samples from patients with CRSwNP.…”

Section: Discussionmentioning

confidence: 58%

“…In a previous study, we showed that CT scores were significantly higher in elderly patients with CRS compared with the nonelderly. Although there was a trend toward more prevalent NP and asthma in elderly patients with CRS compared with the nonelderly, it was not statistically significant (8). When 148 subjects were added to this analysis, NP and asthma were significantly more prevalent in elderly patients with CRS in our tertiary care cohort compared with nonelderly patients (Table 1).…”

Section: Np and Asthma Were More Prevalent In Elderly Patients With Crsmentioning

confidence: 76%

“…We recently reported that elderly patients with CRS had significantly higher computed tomography (CT) scores compared with those of nonelderly patients (8). We also showed that the expression of S100 proteins is reduced in patients with CRS (9), and that S100A8/9 was further decreased in elderly patients with CRS (8).…”

mentioning

confidence: 86%

“…Patients who had taken oral or nasal steroids within 2 to 4 weeks prior to sample collection were excluded from this study. A description of patients as "elderly" was based on having attained an age of 60 years or more, as in our previous study (8). This study was approved by the institutional review board of Northwestern University.…”

Section: Subjectsmentioning

confidence: 99%

“…We also showed that the expression of S100 proteins is reduced in patients with CRS (9), and that S100A8/9 was further decreased in elderly patients with CRS (8). S100A8/9 is important in epithelial barrier function and has antimicrobial activity against bacteria and fungi (10).…”

mentioning

confidence: 92%

See 4 more Smart Citations

Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling

Cho

Kim

Lee

et al. 2015

Am J Respir Cell Mol Biol

Self Cite

View full text Add to dashboard Cite

We report that S100 proteins were reduced in patients with chronic rhinosinusitis (CRS). S100A8/9, which is important in epithelial barrier function, was particularly decreased in elderly patients with CRS. Epithelial expression of S100A8/9 is partly regulated by the IL-6 trans-signaling pathway. The goal of this study was to investigate whether or not age-related reduction of S100A8/9 in CRS is associated with blunting of IL-6 trans-signaling. The levels of IL-6, soluble IL-6 receptor (sIL-6R), soluble gp130 (sgp130), and S100A8/9 from control subjects (n = 10), and patients with CRS without nasal polyps (n = 13) and those with CRS with nasal polyps (CRSwNP) (n = 14), were measured by ELISA. Age-related differences in the level of each protein were investigated. Normal human bronchial epithelial cells were cultured in air-liquid interface and stimulated with IL-6/ sIL-6R and tumor necrosis factor (TNF)-a with or without the addition of sgp130, a natural inhibitor of IL-6 trans-signaling. There was a significant age-related decline in S100A8/9 and an increase in sgp130 in nasal tissue samples from patients with CRSwNP, although there was no age-related difference in IL-6/sIL-6R production.Additionally, expression of the S100A8/9 gene and protein was increased significantly by IL-6/sIL-6R plus TNF-a in normal human bronchial epithelial cells. This increase was blocked by sgp130. These results suggest that increased sgp130 in older patients may inhibit IL-6 trans-signaling, impair barrier function, and decrease S1008/9 production in elderly patients with CRSwNP. Restoration of barrier function by targeting sgp130 may be a novel treatment strategy.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Np and Asthma Were More Prevalent In Elderly Patients With Crsmentioning

confidence: 76%

mentioning

confidence: 86%

Section: Subjectsmentioning

confidence: 99%

mentioning

confidence: 92%

See 3 more Smart Citations

Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling

Cho

Kim

Lee

et al. 2015

Am J Respir Cell Mol Biol

Self Cite

View full text Add to dashboard Cite

show abstract

Short-course oral steroids alone for chronic rhinosinusitis

Chong¹,

Head²,

Hopkins³

et al. 2015

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Background This review is one of a suite of six Cochrane reviews looking at the primary medical management options for patients with chronic rhinosinusitis. Chronic rhinosinusitis is a common condition involving inflammation of the lining of the nose and paranasal sinuses. It is characterised by nasal blockage and nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Oral corticosteroids are used to control the inflammatory response and improve symptoms. Objectives To assess the effects of oral corticosteroids compared with placebo/no intervention or other pharmacological interventions (intranasal corticosteroids, antibiotics, antifungals) for chronic rhinosinusitis. Search methods The Cochrane ENT Information Specialist searched the ENT Trials Register; Central Register of Controlled Trials (CENTRAL 2015, Issue 7); MEDLINE; EMBASE; ClinicalTrials.gov; ICTRP and additional sources for published and unpublished trials. The date of the search was 11 August 2015. Selection criteria Randomised controlled trials (RCTs) comparing a short course (up to 21 days) of oral corticosteroids with placebo or no treatment or compared with other pharmacological interventions. Data collection and analysis We used the standard methodological procedures expected by Cochrane. Our primary outcomes were disease-specific health-related quality of life (HRQL), patient-reported disease severity, and the adverse event of mood or behavioural disturbances. Secondary outcomes included general HRQL, endoscopic nasal polyp score, computerised tomography (CT) scan score and the adverse events of insomnia, gastrointestinal disturbances and osteoporosis. We used GRADE to assess the quality of the evidence for each outcome; this is indicated in italics.

show abstract

Short-course oral steroids alone for chronic rhinosinusitis

Head

Chong

Hopkins

et al. 2016

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

At the end of the treatment course (two to three weeks) there is an improvement in health-related quality of life and symptom severity in patients with chronic rhinosinusitis with nasal polyps taking oral corticosteroids compared with placebo or no treatment. The quality of the evidence supporting this finding is low. At three to six months after the end of the oral steroid treatment period, there is little or no improvement in health-related quality of life or symptom severity for patients taking an initial course of oral steroids compared with placebo or no treatment.The data on the adverse effects associated with short courses of oral corticosteroids indicate that there may be an increase in insomnia and gastrointestinal disturbances but it is not clear whether there is an increase in mood disturbances. All of the adverse events results are based on low quality evidence.More research in this area, particularly research evaluating patients with chronic rhinosinusitis without nasal polyps, longer-term outcomes and adverse effects, is required.There is no evidence for oral steroids compared with other treatments.

show abstract

Age-related differences in the pathogenesis of chronic rhinosinusitis

Cited by 68 publications

References 9 publications

Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling

Age-Related Increased Prevalence of Asthma and Nasal Polyps in Chronic Rhinosinusitis and Its Association with Altered IL-6 Trans-Signaling

Short-course oral steroids alone for chronic rhinosinusitis

Short-course oral steroids alone for chronic rhinosinusitis

Contact Info

Product

Resources

About