Age-related differences in stress responsiveness of the hypothalamic-pituitary-adrenal axis of nonhuman primates with various types of adaptive behavior

Goncharova, N. D.; Oganyan, T. É.

doi:10.1016/j.ygcen.2017.08.007

Cited by 18 publications

(33 citation statements)

References 68 publications

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“…For example, the age‐related decrease in the CORT response to ASE detected in female rhesus monkeys in the afternoon, was accompanied by a decrease in the magnitude of the stress induced rise in erythrocyte glutathione reductase activity, a disturbance of superoxide dismutase activity and the development of oxidative stress. [ 9,48 ] The results of clinical studies indicate a higher risk in elderly people of developing, in association with circadian rhythm disorders, various pathologies, in particular anxiety disorders and depression, cardiovascular, neurodegenerative, metabolic, and oncological diseases. [ 20,26,27,41,49 ]…”

Section: Responsivity Of the Hpa Axis To Stress Is Dependent On The Tmentioning

confidence: 99%

“…A number of publications have failed to report age‐related disturbances in the circadian rhythm of CORT secretion or reported increased CORT levels in aged individuals immediately after waking in the morning. [ 22,40,50,51 ] In addition, in the case of aging in humans and animals, variants of the HPA axis reaction to ASE were revealed, including a decrease in reactivity, [ 21,22,39 ] increase in reactivity, [ 9,52 ] and absence of significant age‐related change [ 22,39,52 ]…”

Section: Responsivity Of the Hpa Axis To Stress Is Dependent On The Tmentioning

confidence: 99%

“…Indeed, the number of publications devoted to the study of HPA axis dysfunction in humans and animals in association with disorders involving aggression, anxiety, and depressive behavior is growing. [ 2,3,7–15 ] Considerable research is carried out on HPA axis function in healthy persons and animals with high levels of anxiety or in patients with depression and anxiety disorders compared with individuals demonstrating healthy adaptive behavior. [ 2,3,7,9–13 ] Most often, healthy people with increased anxiety ratings and patients with anxiety disorders and depression demonstrated increased sensitivity of the HPA axis to stress and vulnerability to post‐stress disorders.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2,3,7–15 ] Considerable research is carried out on HPA axis function in healthy persons and animals with high levels of anxiety or in patients with depression and anxiety disorders compared with individuals demonstrating healthy adaptive behavior. [ 2,3,7,9–13 ] Most often, healthy people with increased anxiety ratings and patients with anxiety disorders and depression demonstrated increased sensitivity of the HPA axis to stress and vulnerability to post‐stress disorders. [ 2,3,7,12,16 ] A greater response of the HPA axis to stress exposure has also been noted in healthy animals with anxiety and depression‐like behavior.…”

Section: Introductionmentioning

confidence: 99%

“…[ 2,3,7,12,16 ] A greater response of the HPA axis to stress exposure has also been noted in healthy animals with anxiety and depression‐like behavior. [ 2,9,17,18 ] Part of such research, however, has focused on stress in early life and did not address changes associated with aging. [ 12,13,19 ]…”

Section: Introductionmentioning

confidence: 99%

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The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

Goncharova

2020

BioEssays

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With aging, incidence of severe stress‐related diseases increases. However, mechanisms, underlying individual vulnerability to stress and age‐related diseases are not clear. The goal of this review is to analyze finding from the recent literature on age‐related characteristics of the hypothalamic‐pituitary‐adrenal (HPA) axis associated with stress reactivity in animals that show behavioral signs of anxiety and depression under mild stress, and in human patients with anxiety disorders and depression with emphasis on the impact of the circadian rhythm and the negative feedback mechanisms involved in the stress response. One can conclude that HPA axis reaction to psycho‐emotional stress, at least acute stress, increases in the aged individuals with anxiety and depression behavior. Elevated stress reactivity is associated with disruption of the circadian rhythm and the mineralocorticoid receptor‐mediated glucocorticoid negative feedback. The disordered function of the HPA axis in individuals with anxiety and depression behavior can contribute to aging‐related pathology.

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Section: Responsivity Of the Hpa Axis To Stress Is Dependent On The Tmentioning

confidence: 99%

Section: Responsivity Of the Hpa Axis To Stress Is Dependent On The Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

Goncharova

2020

BioEssays

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Salivary cortisol captures endocrine response to an acute stressor in captive female tufted capuchin monkeys (Sapajus apella)

DeSana,

Morgan Benowitz‐Fredericks,

Amano

et al. 2024

American J Primatol

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Measuring glucocorticoids such as cortisol is a useful tool for exploring relationships among behavior, physiology, and well‐being in primates. As cortisol circulates in blood, it moves into biological matrices such as hair, urine, feces, and saliva. Saliva sampling is a simple, noninvasive method to measure cortisol that can be easily implemented by training animals to voluntarily provide samples. The temporal lag between elevation of cortisol in the blood and elevation of cortisol in saliva likely varies by species and must be characterized to identify appropriate sampling regimens. In the present study we characterized the time course of cortisol changes in saliva following an acute psychological stressor in captive tufted capuchin monkeys (Sapajus apella). We trained eight free‐moving female tufted capuchin monkeys to voluntarily produce clean saliva samples. We exposed them to the acute stressor of a veterinary catch net and observed behavior pre and post exposure. We collected salivary samples immediately pre exposure (0 min) and 30, 45, 60, 75, 90, and 120 min after exposure. Salivary cortisol was quantified using a Salimetrics kit. Behavioral and cortisol measures were compared within individuals to a control condition in which no stressor was presented. Capuchins showed a clear behavioral response to the stressor by demonstrating increased freezing and pacing, decreased feed foraging, nonsocial play, and scratching, and decreased willingness to provide saliva samples after stressor presentation. After stressor presentation, average salivary cortisol began to increase at 30 min and continued to increase through the 120 min sample period. There was individual variation in absolute cortisol levels, the timing of the cortisol increase, and the timing of the peak. Our results suggest that no single time‐point can be reliably used to evaluate salivary cortisol response to an acute stressor across individuals, and instead we recommend the collection of a prolonged time series.

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Effect of Vasopressin V1b Receptor Blockade on Activity of the Hypothalamic—Pituitary—Adrenal Axis in Old Monkeys with Depression-Like and Anxious Behavior Subjected to Stress or Injected with Vasopressin

2018

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Age-related differences in stress responsiveness of the hypothalamic-pituitary-adrenal axis of nonhuman primates with various types of adaptive behavior

Cited by 18 publications

References 68 publications

The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

Salivary cortisol captures endocrine response to an acute stressor in captive female tufted capuchin monkeys (Sapajus apella)

Effect of Vasopressin V1b Receptor Blockade on Activity of the Hypothalamic—Pituitary—Adrenal Axis in Old Monkeys with Depression-Like and Anxious Behavior Subjected to Stress or Injected with Vasopressin

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