Effect of Vasopressin V1b Receptor Blockade on Activity of the Hypothalamic—Pituitary—Adrenal Axis in Old Monkeys with Depression-Like and Anxious Behavior Subjected to Stress or Injected with Vasopressin

Goncharova, N. D.; Chigarova, O. A.; Oganyan, T. É.

doi:10.1007/s10517-018-4294-4

Cited by 4 publications

(4 citation statements)

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“…[ 9,18,19,21,22,40 ] In this regard, systematic studies performed using non‐human primates (female rhesus monkeys), showing, along with the usual standard behavior (SB, normal, control behavior), anxiety and depression‐like behavior (DAB) under mild to moderate stress are of considerable interest. [ 9,19,21,22,57,58 ] The presence of different behavioral responses of individuals of this species of primate under conditions of mild stress has been noted by various authors, both in individuals living in the wild, [ 15 ] and individuals placed individually in the room. [ 13,17,59 ] Studies along these lines have shown that young adult female rhesus monkeys with DAB or SB show no intergroup differences in response of the HPA axis to the ASE (restraint for 2 h begun at 15 h) ( Figure 3 ).…”

Section: Individual and Age‐related Features Of Hpa Axis Response To mentioning

confidence: 99%

“…The results of tests with CRH and AVP, as well as a selective antagonist of vasopressin V1b receptors, are consistent with this position. [ 57,58 ] The inhibitory activity of the GABAergic neural pathway on the secretory activity of CRH neurons of the PVN in old animals with DAB may also be weakened due to lower concentrations of DHEAS compared to young animals and to old animals with SB. [ 9,22,57 ] As is known, DHEA and DHEAS function in the brain as endogenous neurosteroids with negative modulating effects on the GABAergic system.…”

Section: Individual and Age‐related Features Of Hpa Axis Response To mentioning

confidence: 99%

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The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

Goncharova

2020

BioEssays

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With aging, incidence of severe stress‐related diseases increases. However, mechanisms, underlying individual vulnerability to stress and age‐related diseases are not clear. The goal of this review is to analyze finding from the recent literature on age‐related characteristics of the hypothalamic‐pituitary‐adrenal (HPA) axis associated with stress reactivity in animals that show behavioral signs of anxiety and depression under mild stress, and in human patients with anxiety disorders and depression with emphasis on the impact of the circadian rhythm and the negative feedback mechanisms involved in the stress response. One can conclude that HPA axis reaction to psycho‐emotional stress, at least acute stress, increases in the aged individuals with anxiety and depression behavior. Elevated stress reactivity is associated with disruption of the circadian rhythm and the mineralocorticoid receptor‐mediated glucocorticoid negative feedback. The disordered function of the HPA axis in individuals with anxiety and depression behavior can contribute to aging‐related pathology.

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Section: Individual and Age‐related Features Of Hpa Axis Response To mentioning

confidence: 99%

Section: Individual and Age‐related Features Of Hpa Axis Response To mentioning

confidence: 99%

The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

Goncharova

2020

BioEssays

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“…It is, thus, not surprising that V 1b receptor antagonists, inhibiting AVP and CRH-induced ACTH release, have raised experimental interest as potential agents for the treatment of stress-related disorders and MDD (95). First clinical trials have supported anxiolytic-and antidepressant-like effects of such agents (e.g., SSR149415) in various animal-model and human clinical studies (96)(97)(98)(99)(100) and suggest that the V 1b receptor is required to drive the HPA axis response to acute antidepressant treatment (40,101).…”

Section: Discussionmentioning

confidence: 99%

Vasopressin Surrogate Marker Copeptin as a Potential Novel Endocrine Biomarker for Antidepressant Treatment Response in Major Depression: A Pilot Study

et al. 2020

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Background: Major depressive disorder (MDD) constitutes the leading cause of disability worldwide. Although efficacious antidepressant pharmacotherapies exist for MDD, only about 40-60% of the patients respond to initial treatment. However, there is still a lack of robustly established and applicable biomarkers for antidepressant response in everyday clinical practice.Objective: This study targets the assessment of the vasopressin (AVP) surrogate marker Copeptin (CoP), as a potential peripheral hypothalamic-level biomarker of antidepressant treatment response in MDD.Methods: We measured baseline and dynamic levels of plasma CoP along with plasma ACTH and cortisol (CORT) in drug-naive outpatients with MDD before and after overnight manipulation of the hypothalamic-pituitary-adrenal (HPA) axis [i.e., stimulation (metyrapone) and suppression (dexamethasone)] on three consecutive days and their association with treatment response to 4 weeks of escitalopram treatment.Results: Our findings suggest significantly higher baseline and post-metyrapone plasma CoP levels in future non-responders, a statistically significant invert association between baseline CoP levels and probability of treatment response and a potential baseline plasma CoP cut-off level of above 2.9 pmol/L for future non-response screening. Baseline and dynamic plasma ACTH and CORT levels showed no association with treatment response.Conclusions: This pilot study provide first evidence in humans that CoP may represent a novel, clinically easily applicable, endocrine biomarker of antidepressant response, based on a single-measurement, cut-off level. These findings, underline the role of the vasopressinergic system in the pathophysiology of MDD and may represent a

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“…Earlier, we obtained data to conclude that in old primates with depression-like and anxiety-like behavior the activity of specific vasopressin V1b receptors on corticotrophs of the anterior pituitary was increased. So, we supposed an increase in the activity of specific receptors to CRH (CRHRI) on corticotrophs of the pituitary gland (13, 18, 19, 21). In turn, an increase in the concentration of specific receptors on corticotrophs in individuals with depression-like and anxiety-like behavior could be a consequence of increased synthesis and secretion of CRH and AVP in the pituitary portal system.…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid Negative Feedback in Regulation of the Hypothalamic-Pituitary-Adrenal Axis in Rhesus Monkeys With Various Types of Adaptive Behavior: Individual and Age-Related Differences

et al. 2019

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The study of the mechanisms underlying the increased vulnerability of the individual to stressful environmental factors in different age periods is of great relevance for prevention and effective treatment of stress-dependent diseases that are widespread in the population of aging individuals. The purpose of our study was to investigate the individual and age-related features of the glucocorticoid negative feedback in regulation of the hypothalamic-pituitary-adrenal (HPA) axis, the key adaptive neuroendocrine system, in experiments with physically healthy young and old female rhesus monkeys with administration of mineracorticoid receptor (fludrocortisone) and glucocorticoid receptor (dexamethasone) agonists. We studied the monkeys with increased trait anxiety and depression-like behavior (DAB) characterized, as previously was shown, by the increased vulnerability to acute stress and the animals with normal standard behavior (SB) as the control. The pronounced individual differences in the reaction of HPA axis to fludrocortisone and dexamethasone in young animals were found. Young animals with DAB showed a lower sensitivity of HPA axis to the inhibitory effect of both fludrocortisone and dexamethasone compared with young animals with SB. At the same time, there were no significant intergroup differences in the concentration of ACTH and cortisol in response to placebo injection, i.e., in basal conditions. The old individuals with DAB demonstrated the essential relative resistance of HPA axis to fludrocortisone test and higher basal plasma levels of cortisol and ACTH in the evening (the period of HPA axis low circadian activity) compared to old SB animals. In the same time, the intergroup differences in the response of HPA axis to dexamethasone administration were leveled due to age-related increase in sensitivity of HPA axis to dexamethasone in animals with DAB. These data testify the pronounced intergroup and age differences in the feedback regulation of HPA axis, presumably resulting from unequal individual, and age-related changes in the activity of mineralcorticoid and glucocorticoid receptors in the brain structures supporting the functions of HPA axis. The maximum age disorders in functioning of the negative feedback mechanism in the regulation of HPA axis are characteristic of animals with DAB, which, apparently, underlie the increased vulnerability of these animals to stress exposure.

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Effect of Vasopressin V1b Receptor Blockade on Activity of the Hypothalamic—Pituitary—Adrenal Axis in Old Monkeys with Depression-Like and Anxious Behavior Subjected to Stress or Injected with Vasopressin

Cited by 4 publications

References 8 publications

The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time

Vasopressin Surrogate Marker Copeptin as a Potential Novel Endocrine Biomarker for Antidepressant Treatment Response in Major Depression: A Pilot Study

Glucocorticoid Negative Feedback in Regulation of the Hypothalamic-Pituitary-Adrenal Axis in Rhesus Monkeys With Various Types of Adaptive Behavior: Individual and Age-Related Differences

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