Age-related differences in breast cancer stage at diagnosis between black and white patients in an urban community hospital

Newman, Lisa A.; Alfonso, Antonio E.

doi:10.1007/bf02303751

Cited by 37 publications

(27 citation statements)

References 28 publications

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“…7,28,29 Other investigations have shown that equal access to medical care does not eliminate completely the survival disadvantage for African American women, [30][31][32][33] and race alone has been suggested as an independent predictor for survival. [34][35][36] African American women were noted to have significantly earlier age at diagnosis, high grade tumors, and a higher proportion of ERnegative and PR-negative cancers, 3,6,[37][38][39][40][41][42] suggesting that breast cancer is biologically different in African American women.…”

Section: Discussionmentioning

confidence: 99%

Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype

Bauer

Brown

Cress

et al. 2007

Cancer

1,817

105

1,442

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BACKGROUND.Tumor markers are becoming increasingly important in breast cancer research because of their impact on prognosis, treatment, and survival, and because of their relation to breast cancer subtypes. The triple‐negative phenotype is important because of its relation to the basal‐like subtype of breast cancer.METHODS.Using the population‐based California Cancer Registry data, we identified women diagnosed with triple‐negative breast cancer between 1999 and 2003. We examined differences between triple‐negative breast cancers compared with other breast cancers in relation to age, race/ethnicity, socioeconomic status (SES), stage at diagnosis, tumor grade, and relative survival.RESULTS.A total of 6370 women were identified as having triple‐negative breast cancer and were compared with the 44,704 women with other breast cancers. Women with triple‐negative breast cancers were significantly more likely to be under age 40 (odds ratio [OR], 1.53), and non‐Hispanic black (OR, 1.77) or Hispanic (OR, 1.23). Regardless of stage at diagnosis, women with triple‐negative breast cancers had poorer survival than those with other breast cancers, and non‐Hispanic black women with late‐stage triple‐negative cancer had the poorest survival, with a 5‐year relative survival of only 14%.CONCLUSIONS.Triple‐negative breast cancers affect younger, non‐Hispanic black and Hispanic women in areas of low SES. The tumors were diagnosed at later stage and were more aggressive, and these women had poorer survival regardless of stage. In addition, non‐Hispanic black women with late‐stage triple‐negative breast cancer had the poorest survival of any comparable group. Cancer 2007. © 2007 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype

Bauer

Brown

Cress

et al. 2007

Cancer

1,817

105

1,442

View full text Add to dashboard Cite

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“…However, Newman and Alfonso, 4 Muss et al, 28 and Ownby et al 13 found no significant differences in ER or progesterone receptor (PR) status in African-American women compared with white women.Similarly, Elmore et al 2 found no difference in ER expression in tumors involving African-American and white patients and Chen et al 12 reported no statistical difference in ER status between African-American and white patients. However, using data from the 1982 national survey of breast cancer, Natarajan et al 14 found that only 63% of African-American patients with breast cancer had ER-positive tumors compared with 74% of white women over the age of 50.In women younger than 50 years of age, 45% of African-American patients had ER-positive tumors compared with 58% of white women.…”

Section: Hormonal Status Of Tumorsmentioning

confidence: 98%

“…Ownby et al, 13 Simon and Severson, 9 Newman and Alfonso, 4 Mittra et al, 26 and Chen et al 12 reported no variation in tumor histology by race. In addition, Williams et al 27 did not find an increase in medullary carcinoma among the 1270 African-American women studied at Howard University Hospital.…”

Section: Medullary Carcinomamentioning

confidence: 98%

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Histopathology of breast cancer among African-American women

Middleton

Chen

Perkins

et al. 2002

Cancer

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Although the overall incidence of breast cancer in African-American women is lower than in white women, African-American women younger than 50 years old have a higher incidence of breast cancer than white women. African-American women with breast cancer have a poorer survival rate than white women and are more likely to die of breast cancer in almost every age group. To explain this disparity, we studied a substantial body of literature that reported a biologic difference in the tumors found in African-American and white women. Specifically, more aggressive histopathologic patterns have been described among AfricanAmerican patients with breast cancer when compared with white women. In addition, there are data that support an ethnicity-related variation in the expression of breast tumor hormonal markers. The objective of this study was to critically evaluate the existing published data on the histologic features of breast cancer to determine whether breast cancer in African-American women is a histologically more aggressive disease than in white women. We conclude that the aggressive tumor histology reported in African-American women has not been analyzed carefully with respect to the age of the patient at the time of diagnosis and the stage of disease at presentation. Furthermore, there is a need for central pathology review using accepted, published criteria for diagnosis of uncommon and contro- Age of OnsetAlthough the overall incidence of breast cancer is lower among African-American women than among white women, the incidence rates among African-American women younger than 50 years old are higher than among white women.1 In general, African-American women develop breast cancer 5-10 years earlier than white women. 2,3In the Surveillance, Epidemiology, and End Results program, the median age at diagnosis of breast cancer for African-American women was 57.0 compared with 64.0 for white women.1 Newman and Alfonso 4 evaluated breast cancer in women younger than 50 years old and found that significantly more African-American patients than white patients were diagnosed at a young age. Similarly, Kovi et al. 5 reported that a higher percentage of African-American women (68%) younger than 54 years old were diagnosed with breast cancer compared with white women of the same age (53%). Their observation was based on data compiled by the Armed Forces Institute of Pathology experience with breast cancer from 1980 to 1983. 253

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“…1 Current reports indicates that cancer of the breast is the commonest malignancy in females affecting more than a million females annually, 2 with an increasing incidence as the women presumably adopt a western life style. 3 The black woman, believed to be at higher risk than her white counterpart, seem to develop her lesion at an earlier age, 4 present with a bigger mass and late for treatment. 5,6, The life time risk of breast cancer is about 10% for white women and 7.3% for black women.…”

Section: Mots Clés: Examen De Sein-individu Cancer De Sein éDucatiomentioning

confidence: 99%

Knowledge and practice of breast-self examination among female undergraduate students of Ahmadu Bello University Zaria, Northwestern Nigeria

2009

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Background: Carcinoma of the breast is an important public health problem in Nigeria and studies have reported low levels of awareness and practice of breast self examination as an important method of prevention. Breast self examination is a cost-effective method of early detection of cancer of the breast especially in resource poor countries. We assessed knowledge and practice of breast-self examination (BSE) among female undergraduate students of Ahmadu Bello University Zaria, Nigeria. Method: In this study, knowledge and practice of BSE were examined among 221 female students aged 16 -28 years old studying at Ahmadu Bello University Zaria using self administered questionnaires. Results: It was found that despite nearly three quarter of the respondents (87.7%) had heard of BSE, only 19.0% of them were performing this examination monthly. Regarding the sources of information about BSE among respondents, media was found to be most common followed by health workers accounting for 45.5% and 32.2% respectively. Regular performance of BSE was significantly correlated with duration of stay in the University (X 2 = 81.9, df = 3, P < .05) and family history of breast cancer (X 2 = 17.4, df = 2, P < .05). Conclusion:We observed a disparity between high levels of knowledge of BSE compared to a low level of practice. Public health education using the media could significantly reduce the knowledge-practice gap and early detection of breast lump. Key words: Breast-self examination, breast cancer, health educationRésumé Fond: Le carcinome du sein est un problème important de santé publique au Nigéria et les études ont indiqué les niveaux bas de la conscience et la pratique de l'examen de conscience de sein comme méthode importante d'empêchement. L'examen de conscience de sein est une méthode rentable de dépistage précoce du cancer du sein particulièrement dans les pays pauvres de ressource. Nous la connaissance et pratique évaluées de l'examen de sein-individu (ESB) parmi les étudiants d'étudiant préparant une licence féminins de l'université Zaria, Nigéria d'Ahmadu Bello. Méthode: Dans cette étude, la connaissance et la pratique de l'ESB ont été examinées parmi 221 étudiants féminins âgés 16 -28 ans de étudier à l'université Zaria d'Ahmadu Bello en utilisant les questionnaires administrés par individu. Résultats :On l'a constaté qu'en dépit presque de de trois quarts des répondants (87.7%) avait entendu parler de l'ESB, seulement 19.0% d'entre eux exécutaient cette revue mensuelle d'examen. Concernant les sources d' informations sur l'ESB parmi des répondants, des médias se sont avérés plus terrain Knowledge and practice of breast self-examination among female undergraduate students. Gwarzo U. M. D. et al.

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Age-related differences in breast cancer stage at diagnosis between black and white patients in an urban community hospital

Cited by 37 publications

References 28 publications

Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype

Descriptive analysis of estrogen receptor (ER)‐negative, progesterone receptor (PR)‐negative, and HER2‐negative invasive breast cancer, the so‐called triple‐negative phenotype

Histopathology of breast cancer among African-American women

Knowledge and practice of breast-self examination among female undergraduate students of Ahmadu Bello University Zaria, Northwestern Nigeria

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