Histopathology of breast cancer among African-American women

Middleton, Lavinia P.; Chen, Vivien; Perkins, George H.; Pinn, Vivian W.; Page, David L.

doi:10.1002/cncr.11021

Cited by 48 publications

(43 citation statements)

References 24 publications

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“…Studies have found that tumour characteristics such as grade, hr status, and other unknown pathologic features vary with ethnicity, although no study has specifically included fn women 17,[42][43][44] . Among women diagnosed at stages ii-iv, we found a significant difference in grade and hr status for fn women compared with aom women.…”

Section: Discussionmentioning

confidence: 99%

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

et al. 2016

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“…Hypermethylation of a tumor suppressor gene BRCA1 has been reported in 11-32% of primary sporadic breast carcinomas (26 -29), and methylation strongly correlated with lack of ER/PR receptor expression (26,29). BRCA1 methylation has also been found to be more strongly associated with the uncommon (Ͻ5%) medullary and mucinous subtypes of breast cancer (27), which some studies report are more frequent in AA cancers (30). A recent study observed that HIN-1 methylation is significantly higher in ERϩ breast tumors than ERϪ tumors (28).…”

Section: Discussionmentioning

confidence: 99%

Estrogen Receptor/Progesterone Receptor-Negative Breast Cancers of Young African-American Women Have a Higher Frequency of Methylation of Multiple Genes than Those of Caucasian Women1

Mehrotra¹,

Ganpat²,

Kanaan³

et al. 2004

Clinical Cancer Research

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Purpose: To provide a molecular rationale for negative prognostic factors more prevalent in African-American (AA) than Caucasian (Cau) women, we investigated the frequency of promoter hypermethylation in invasive ductal breast cancers in the two races.Experimental Design: HIN-1, Twist, Cyclin D2, RAR-␤, and RASSF1A were analyzed in DNA from 67 AA and 44 Cau invasive ductal breast cancers, stratified by age and estrogen receptor/progesterone receptor (ER/PR) status, by methylation-specific PCR. Hierarchical multiple logistic regression analysis was applied to determine estimated probabilities of methylation. Expression of HIN-1 mRNA was analyzed by in situ hybridization and quantitative reverse transcribed PCR.Results: Significant differences between races were observed in the ER؊/PR؊, age < 50 subgroup; AA tumors had higher frequency of methylation (P < 0.001) in four of five genes as compared with Cau and also a higher prevalence (80 versus 0%; P < 0.005) of three or more methylated genes per tumor. No differences in gene methylation patterns were observed across the two races for ER؉/PR؉ tumors in all ages and ER؊/PR؊ tumors in age > 50. ER؉/PR؉ status was associated with higher frequency of methylation in Cau tumors of all ages but only with the age > 50 subgroup in AA. Frequent Cyclin D2 methylation was significantly associated (P ‫؍‬ 0.01) with shorter survival time.Conclusion: ER؊/PR؊, age < 50 tumors in AA women, have a significantly higher frequency of hypermethylation than in those of Cau women. Comparative studies, such as these, could provide a molecular basis for differences in tumor progression and pathology seen in the two races.

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“…Among women younger than 50 years, African Americans are not only at a greater risk for developing breast cancer but may also be more likely to present with more aggressive, steroid receptor negative, higher-grade tumors (1)(2)(3)(4). Asian Americans have traditionally had lower rates of breast cancer across all age groups compared with Caucasians and African Americans (5).…”

Section: Introductionmentioning

confidence: 99%

Racial Differences in Premenopausal Endogenous Hormones

Pinheiro

Holmes

Pollak

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

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Differences in breast cancer incidence across racial groups are well documented. African Americans have the highest rates of premenopausal breast cancer and Asians have lower breast cancer rates across all age groups. We hypothesized that levels of premenopausal endogenous hormones and growth factors, risk factors that have been predictive of breast cancer, would differ by race. Using a cross-sectional study design, we tested this hypothesis in the Nurses' Health Study II. We assayed estradiol, progesterone, prolactin, sex hormone binding globulin (SHBG), insulin-like growth factor-I (IGF-I), and IGFBP-3 in 111 African American and 111 Asian American women, matched to 111 Caucasian women on age, day of luteal phase, and day, time, and fasting status at blood collection. We analyzed the association between race and hormone levels using robust linear regression methods. In multivariate models, compared with Caucasians, African Americans had 18% higher levels of estradiol (P < 0.01), 17% higher free estradiol (P < 0.01), 11% lower SHBG (P = 0.05), 11% higher IGF-I (P < 0.01), 25% higher free IGF-I (P < 0.01), and 9% lower IGFBP-3 (P < 0.01) levels. In multivariate models, compared with Caucasian women, Asian Americans had 22% higher calculated free estradiol (P < 0.01), 31% lower SHBG (P < 0.01), and 25% higher free IGF-I (P < 0.01) levels. No racial differences were found in progesterone and prolactin levels. Our study showed hormone differences consistent with breast cancer risk between Caucasians and African Americans but inconsistent with breast cancer risk between Asian Americans and Caucasians. Further research is needed to explore differences across racial groups and the link between endogenous hormones and breast cancer risk. (Cancer Epidemiol Biomarkers Prev 2005;14(9):2147 -53)

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Histopathology of breast cancer among African-American women

Cited by 48 publications

References 24 publications

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

Cancer Incidence, Mortality, and Stage at Diagnosis in First Nations Living in Manitoba

Estrogen Receptor/Progesterone Receptor-Negative Breast Cancers of Young African-American Women Have a Higher Frequency of Methylation of Multiple Genes than Those of Caucasian Women1

Racial Differences in Premenopausal Endogenous Hormones

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