Age-related decline in peak oxygen uptake: Cross-sectional vs. longitudinal findings. A review

Letnes, Jon Magne; Nes, Bjarne M.; Wisløff, Ulrik

doi:10.1016/j.ijcrp.2023.200171

Cited by 14 publications

(9 citation statements)

References 58 publications

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“…However, these findings and those of our review suggest that SB interventions, which likely have less of an effect on MVPA [ 110 ], can maintain and in some cases improve CRF. This is an important finding given the known age-related declines in adult CRF [ 59 , 111 , 112 ], suggesting that incidental/lower intensity physical activity may be sufficient to maintain, but not improve, CRF. This has implications for populations in whom increasing MVPA may be a challenge, but reducing or interrupting SB may be more feasible.…”

Section: Discussionmentioning

confidence: 76%

The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis

Prince,

Dempsey,

Reed

et al. 2024

Sports Med

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Background Cardiorespiratory fitness (CRF) is an important indicator of current and future health. While the impact of habitual physical activity on CRF is well established, the role of sedentary behaviour (SB) remains less understood. Objective We aimed to determine the effect of SB on CRF. Methods Searches were conducted in MEDLINE, Embase, PsycINFO, CINAHL and SPORTDiscus from inception to August 2022. Randomised controlled trials, quasi-experimental studies and cohort studies that assessed the relationship between SB and CRF were eligible. Narrative syntheses and meta-analyses summarised the evidence, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) certainty was based on evidence from randomised controlled trials. Results This review included 18 studies that focused on youth (four randomised controlled trials, three quasi-experimental studies, 11 cohort studies) and 24 on adult populations (15 randomised controlled trials, five quasi-experimental studies, four cohort studies). In youth and adults, evidence from randomised controlled trials suggests mixed effects of SB on CRF, but with the potential for interventions to improve CRF. Quasi-experimental and cohort studies also support similar conclusions. Certainty of evidence was very low for both age groups. A meta-analysis of adult randomised controlled trials found that interventions targeting reducing SB, or increasing physical activity and reducing SB, had a significant effect on post-peak oxygen consumption (mean difference = 3.16 mL.kg–1.min–1, 95% confidence interval: 1.76, 4.57). Conclusions Evidence from randomised controlled trials indicates mixed associations between SB and CRF, with the potential for SB to influence CRF, as supported by meta-analytical findings. Further well-designed trials are warranted to confirm the relationship between SB and CRF, explore the effects of SB independent from higher intensity activity, and investigate the existence of such relationships in paediatric populations. Clinical Trial Registration PROSPERO CRD42022356218.

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Section: Discussionmentioning

confidence: 76%

The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis

Prince,

Dempsey,

Reed

et al. 2024

Sports Med

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“…The current understanding of AD pathogenesis is based on amyloid peptide deposition and the accumulation and phosphorylation of tau proteins around neurons [12][13][14], which leads to neurodegeneration and eventual brain atrophy. Factors associated with AD include age, genetic predisposition [15], Down's syndrome [16], brain injuries [17], and cardiorespiratory fitness [18][19][20]. AD-related cognitive impairment can be broadly separated into three stages: (1) preclinical AD, where measurable changes in the brain, cerebral spinal fluid (CSF), and blood plasma can be detected; (2) mild cognitive impairment (MCI) due to AD, where biomarker evidence of AD-related brain change can be present; and (3) dementia due to AD, where changes in the brain are evident and noticeable memory, thinking and behavioural changes appear and impair an individual's daily function.…”

Section: Alzheimer's Disease and Mild Cognitive Impairmentmentioning

confidence: 99%

A Survey of Deep Learning for Alzheimer’s Disease

Zhou

Wang

et al. 2023

MAKE

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Alzheimer’s and related diseases are significant health issues of this era. The interdisciplinary use of deep learning in this field has shown great promise and gathered considerable interest. This paper surveys deep learning literature related to Alzheimer’s disease, mild cognitive impairment, and related diseases from 2010 to early 2023. We identify the major types of unsupervised, supervised, and semi-supervised methods developed for various tasks in this field, including the most recent developments, such as the application of recurrent neural networks, graph-neural networks, and generative models. We also provide a summary of data sources, data processing, training protocols, and evaluation methods as a guide for future deep learning research into Alzheimer’s disease. Although deep learning has shown promising performance across various studies and tasks, it is limited by interpretation and generalization challenges. The survey also provides a brief insight into these challenges and the possible pathways for future studies.

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“…4,7,11 Large cross-sectional studies have shown that VȮ 2peak typically reduces by ~10% every 10 years, with some longitudinal studies indicating that the rate of deterioration increases to 25% per decade in individuals >70 years. 11 Comparable reductions in both AT and VĖ/VĊO 2 -AT are also observed across the lifespan. 4 Sex differences are also evident across the age range, with both VȮ 2peak and AT being significantly lower in females and modest differences in VĖ/ VĊO 2 -AT typically observed between sexes (Figure 1A).…”

Section: E D I T O R I a L Editorial: Prime Time To Recommend Sex-spe...mentioning

confidence: 99%

“…Normative values for the main parameters evaluated during CPET have been established both between the sexes, and across the age range for healthy individuals 4,7,11 . Large cross‐sectional studies have shown that V̇O 2peak typically reduces by ~10% every 10 years, with some longitudinal studies indicating that the rate of deterioration increases to 25% per decade in individuals >70 years 11 . Comparable reductions in both AT and V̇E/V̇CO 2 ‐AT are also observed across the lifespan 4 .…”

Section: Figurementioning

confidence: 99%

Editorial: Prime time to recommend sex‐specific cardiorespiratory fitness threshold values for pre‐operative risk stratification

Pugh

Williams

2023

Eur J Clin Investigation

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Age-related decline in peak oxygen uptake: Cross-sectional vs. longitudinal findings. A review

Cited by 14 publications

References 58 publications

The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis

The Effect of Sedentary Behaviour on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis

A Survey of Deep Learning for Alzheimer’s Disease

Editorial: Prime time to recommend sex‐specific cardiorespiratory fitness threshold values for pre‐operative risk stratification

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