Age‐related changes of shape and flow dynamics in healthy adult aortas: A 4D flow MRI study

Callaghan, Fraser M.; Bannon, Paul G.; Barin, Edward; Celemajer, David; Jeremy, Richmond W.; Figtree, Gemma A.; Grieve, Stuart M.

doi:10.1002/jmri.26210

Cited by 30 publications

(44 citation statements)

References 28 publications

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“…To our knowledge, no comprehensive studies have been performed to investigate the association between age, gender and ethnicity and valvular flow or valve planimetry in normal healthy subjects based on PC-CMR. Two recent studies using 4D Flow CMR investigated the relationship of aortic flow velocity with age and gender, respectively [ 76 , 77 ]. Callaghan et al [ 76 ] compared measurements of mean peak systolic velocity obtained in the ascending aorta between 3 age groups and found a significant decrease with age.…”

Section: Cardiac Valves and Quantification Of Flowmentioning

confidence: 99%

“…Two recent studies using 4D Flow CMR investigated the relationship of aortic flow velocity with age and gender, respectively [ 76 , 77 ]. Callaghan et al [ 76 ] compared measurements of mean peak systolic velocity obtained in the ascending aorta between 3 age groups and found a significant decrease with age. Garcia et al [ 77 ] showed the mean aortic valve peak velocity was higher with greater age.…”

Section: Cardiac Valves and Quantification Of Flowmentioning

confidence: 99%

See 1 more Smart Citation

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Kawel‐Boehm

Hetzel

Ambale-Venkatesh

et al. 2020

Journal of Cardiovascular Magnetic Resonance

326

243

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Cardiovascular magnetic resonance (CMR) enables assessment and quantification of morphological and functional parameters of the heart, including chamber size and function, diameters of the aorta and pulmonary arteries, flow and myocardial relaxation times. Knowledge of reference ranges (“normal values”) for quantitative CMR is crucial to interpretation of results and to distinguish normal from disease. Compared to the previous version of this review published in 2015, we present updated and expanded reference values for morphological and functional CMR parameters of the cardiovascular system based on the peer-reviewed literature and current CMR techniques. Further, databases and references for deep learning methods are included.

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Section: Cardiac Valves and Quantification Of Flowmentioning

confidence: 99%

Section: Cardiac Valves and Quantification Of Flowmentioning

confidence: 99%

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Kawel‐Boehm

Hetzel

Ambale-Venkatesh

et al. 2020

Journal of Cardiovascular Magnetic Resonance

326

243

View full text Add to dashboard Cite

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“…Numerous new parameters for the assessment of cardiovascular diseases with 4D flow MRI were already defined [3][4][5][6] and different techniques for the semi-automatic assessment of helical flow have been described: recent studies utilized the λ 2 criterion, vorticity, helicity or normalized helicity for evaluation of complex flow patterns in the ascending aorta [7][8][9][10] . However, it has been shown that most of those parameters are susceptible to noise and highly depend on sufficient image quality 11 .…”

mentioning

confidence: 99%

Automated Quantitative Extraction and Analysis of 4D flow Patterns in the Ascending Aorta: An intraindividual comparison at 1.5 T and 3 T

Ebel

Dufke

Köhler

et al. 2020

Sci Rep

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4D flow MRI enables quantitative assessment of helical flow. Current methods are susceptible to noise. To evaluate helical flow patterns in healthy volunteers and patients with bicuspid aortic valves (BAV) at 1.5 T and 3 T using pressure-based helix-extraction in 4D flow MRI. Two intraindividual 4D flow MRI examinations were performed at 1.5 T and 3 T in ten healthy volunteers (5 females, 32 ± 3 years) and 2 patients with BAV using different acceleration techniques (kt-GRAPPA and centra). Several new quantitative parameters for the evaluation of volumes [ml], lengths [mm] as well as temporal parameters [ms] of helical flow were introduced and analyzed using the software tool Bloodline. We found good correlations between measurements in volunteers at 1.5 T and 3 T regarding helical flow volumes (R = 0.98) and temporal existence (R = 0.99) of helices in the ascending aorta. Furthermore, we found significantly larger (11.7 vs. 77.6 ml) and longer lasting (317 vs. 769 ms) helices in patients with BAV than in volunteers. The assessed parameters do not depend on the magnetic field strength used for the acquisition. The technique of pressure-based extraction of 4D flow MRI pattern is suitable for differentiation of normal and pathological flow.

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“…In this work, an approach was introduced that enables the unambiguous reconstruction of periodic lattices with NMR-based diffusion experiments. It has been well known since the early 1990s [1,[23][24][25]33], that the magnitude spectrum ( ) 2 S q could be obtained for these structures. The problem of how to retrieve the phase information was, so far, only solved for closed domains.…”

Section: Discussionmentioning

confidence: 99%

“…In Fig. 1a, we consider the so-called q-space imaging gradient profile, which can be used to determine the voxel-averaged diffusion propagator function [23][24][25][26]. Here, two short gradient pulses of duration s δ and amplitude G are employed generating the wave vector…”

Section: Theorymentioning

confidence: 99%

NMR-based diffusion lattice imaging

2016

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Nuclear magnetic resonance (NMR) diffusion experiments are widely employed as they yield information about structures hindering the diffusion process, e.g., about cell membranes. While it has been shown in recent articles that these experiments can be used to determine the shape of closed pores averaged over a volume of interest, it is still an open question how much information can be gained in open well-connected systems. In this theoretical work, it is shown that the full structure information of connected periodic systems is accessible. To this end, the so-called "SEquential Rephasing by Pulsed field-gradient Encoding N Time intervals" (SERPENT) sequence is used, which employs several diffusion encoding gradient pulses with different amplitudes. Two two-dimensional solid matrices that are surrounded by an NMR-visible medium are considered: a hexagonal lattice of cylinders and a rectangular lattice of isosceles triangles.

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Age‐related changes of shape and flow dynamics in healthy adult aortas: A 4D flow MRI study

Abstract: 3 Technical Efficacy: Stage 1 Stage 1 J. Magn. Reson. Imaging 2018.

Cited by 30 publications

References 28 publications

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Reference ranges (“normal values”) for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update

Automated Quantitative Extraction and Analysis of 4D flow Patterns in the Ascending Aorta: An intraindividual comparison at 1.5 T and 3 T

NMR-based diffusion lattice imaging

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