Age-Related Changes in Working Memory during Sentence Comprehension: An fMRI Study

Grossman, Murray; Cooke, Ayanna; DeVita, Christian; Alsop, David C.; Detre, John A.; Chen, Willis; Gee, James C.

doi:10.1006/nimg.2001.0971

Cited by 155 publications

(115 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies have also reported greater recruitment of temporoparietal regions during semantic processing in normal aging (Grossman, et al, 2002;Nielson, et al, 2006;Peelle, et al, 2010). Grossman et al (2002) concluded that greater activation in the right posterolateral temporoparietal regions for older adults during a sentence comprehension task may reflect a compensatory mechanism enabling older adults to maintain sentence comprehension at the same level as younger adults. This interpretation therefore seems to fit with the CRUNCH model, mentioned previously (Reuter-Lorenz & Cappell, 2008).…”

Section: Discussionmentioning

confidence: 94%

“…Both of these regions have been reported to play a key role in semantic control processes (Jefferies, 2013;Noonan, et al, 2013;Whitney, Kirk, O'Sullivan, Lambon Ralph, & Jefferies, 2012). Other studies have also reported greater recruitment of temporoparietal regions during semantic processing in normal aging (Grossman, et al, 2002;Nielson, et al, 2006;Peelle, et al, 2010). Grossman et al (2002) concluded that greater activation in the right posterolateral temporoparietal regions for older adults during a sentence comprehension task may reflect a compensatory mechanism enabling older adults to maintain sentence comprehension at the same level as younger adults.…”

Section: Discussionmentioning

confidence: 94%

“…Since picture naming (language production) is inherently different from semantic judgment (language comprehension), such differences in the nature of the tasks may account for the dissimilar patterns of prefrontal activation reported in the current study. Indeed, studies investigating the neural bases of semantic processing in normal aging using receptive tasks have reported mainly a pattern of prefrontal hypoactivation in healthy older adults relative to younger adults (Berlingeri, et al, 2010;Grossman, et al, 2002;Peelle, Troiani, Wingfield, & Grossman, 2010;Tyler, et al, 2010), in contrast with a prefrontal hyperactivation in production tasks. These studies, however, focused mainly on syntactic processing of sentence comprehension, which recruits a number of high-order cognitive processes, including complex syntactic comprehension and working memory, which are also known to decline with age (Burke & Shafto, 2008;Wingfield & Grossman, 2006).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

et al. 2015

View full text Add to dashboard Cite

Semantic memory recruits an extensive neural network including the left inferior prefrontal cortex (IPC) and the left temporoparietal region, which are involved in semantic control processes, as well as the anterior temporal lobe region (ATL) which is considered to be involved in processing semantic information at a central level. However, little is known about the underlying neuronal integrity of the semantic network in normal aging. Young and older healthy adults carried out a semantic judgment task while their cortical activity was recorded using magnetoencephalography (MEG). Despite equivalent behavioral performance, young adults activated the left IPC to a greater extent than older adults, while the latter group recruited the temporoparietal region bilaterally and the left ATL to a greater extent than younger adults. Results indicate that significant neuronal changes occur in normal aging, mainly in regions underlying semantic control processes, despite an apparent stability in performance at the behavioral level.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Older participants exhibit extraneous areas of activation and greater bilateral activation in functional homologues (i.e., analogous brain regions in the contralateral hemisphere) where younger adults exhibited asymmetrical activation (Cabeza, 2002;Cabeza et al, 1997b;Grady et al, 1994;Madden et al, 1997Madden et al, , 1999Nielson et al, 2002;Schachter et al, 1996, but see Grady et al, 1995;Jonides et al, 2000;Rypma and D'Esposito, 2000). A number of the imaging studies also report differences between younger and older adults in the inferior parietal lobule and the dorsomedial nucleus of the thalamus (DiGirolamo et al, 2001;Grady et al, 1994Grady et al, , 1995Grossman et al, 2001;Madden et al, 1997Madden et al, , 1999Nielson et al, 2002).…”

Section: Introductionmentioning

confidence: 98%

Frontal recruitment during response inhibition in older adults replicated with fMRI

2003

View full text Add to dashboard Cite

Recent research has explored age-related differences in multiple areas of cognitive functioning using fMRI, PET, and SPECT. However, because these studies used different tasks, subjects, and methods, little is known about whether the results of these studies are generalizable or repeatable. The present study replicated a previous study [Psychol. Aging 17 (2002) 56] NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page.NeuroImage, Vol 20, No. 2 (October 2003): pg. 1384-1392. DOI. This article is © Elsevier and permission has been granted for this version to appear in e-Publications@Marquette. Elsevier does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Elsevier. 2 using the same Go/No-go task with a subset of 11 of the original older adult subjects, and using the same fMRI scanner and imaging methods. A direct comparison was made between these participants at Time 1 and Time 2 for both behavioral and functional data. These participants were also compared to a new young adult group of 11 participants. Although the current young adult group did not perform as well as the original young adult group, the original finding of enhanced left prefrontal activation in older adults relative to younger adults was replicated. Furthermore, when comparing Time 1 to Time 2, older adults exhibited comparable areas of activation, but significantly greater magnitude of activation at Time 1 in a few clusters. The findings indicate that older adults exhibit more bilateral brain activity during this task than young adults, which appears compensatory and is repeatable over time. The magnitude of regional activation, however, may vary with extraneuronal factors such as signal-to-noise ratio or task experience. This study adds to existing research suggesting that bilateral frontal activation is a predominant finding in the aging literature, and not specific to certain tasks in age group comparisons.

show abstract

“…Activation in IFC is reliably seen during a wide variety of tasks that probe grammatical aspects of a sentence (Ben-Shachar, Palti, & Grodzinsky, 2004;Caplan, Alpert, & Waters, 1998;Cooke et al, 2002;Heim, Opitz, & Friederici, 2003;Kang, Constable, Gore, & Avrutin, 1999;Ni et al, 2000;Peelle, McMillan, Moore, Grossman, & Wingfield, 2004), although the precise location of this activation depends on the nature of the stimuli and task demands (Kaan & Swaab, 2002). Some authors conclude that inferior frontal activation specifically supports grammatical structure-building (BenShachar et al, 2004;Caplan, Alpert, Waters, & Olivieri, 2000;Ni et al, 2000), whereas others hold that it also reflects executive resources required for sentence processing (Cooke et al, 2006;Cooke et al, 2002;Grossman et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia

Peelle¹,

Cooke²,

Moore³

et al. 2007

Journal of Neurolinguistics

Self Cite

View full text Add to dashboard Cite

We used an online word-monitoring paradigm to examine sentence processing in healthy seniors and frontotemporal dementia patients with progressive nonfluent aphasia (PNFA) or a nonaphasic disorder of social and executive functioning (SOC/EXEC). Healthy seniors were sensitive to morphosyntactic, major grammatical subcategory, and selection restriction violations in a sentence. PNFA patients were insensitive to grammatical errors, but showed reasonable sensitivity to thematic matrix violations, consistent with a differential grammatical processing impairment. By contrast, SOC/EXEC patients showed partial sensitivity to grammatical errors but were insensitive to thematic violations. These findings support a dissociation between grammatical and thematic components of sentence processing. Specifically, they are consistent with a grammatical processing deficit in PNFA patients, and impairment in the formation of a coherent thematic matrix in SOC/EXEC patients.

show abstract

Age-Related Changes in Working Memory during Sentence Comprehension: An fMRI Study

Cited by 155 publications

References 81 publications

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

Neural changes associated with semantic processing in healthy aging despite intact behavioral performance

Frontal recruitment during response inhibition in older adults replicated with fMRI

Syntactic and thematic components of sentence processing in progressive nonfluent aphasia and nonaphasic frontotemporal dementia

Contact Info

Product

Resources

About