Age-related changes in the vitreus and lens of rhesus monkeys (Macaca mulatta)

Comparative anatomy of the vitreous body in rhesus monkeys and man

“…Also the risk of introducing artefacts by this form of intravitreal manipulation should be taken into account. The latter aspect probably does not play a Very important role, since our findings in both human and monkey eyes are fairly similar to those found by in-vitro slitlamp microscopy in human and monkey eyes [1,3].…”

“…The anatomy of the monkey vitreous was studied by Denlinger et al [3] using in-vivo and in-vitro slitlamp microscopy. They found a remarkable similarity in vitreous anatomy between the rhesus monkey and man.…”

“…The above-mentioned morphological findings and similarities in biochemical and physical behaviour observed by these investigators [3], led them to the conclusion that the vitreous body of the rhesus monkey can serve as an experimental model for the human vitreous.…”

Decreased Vitreal Hyaluronan Levels with Aging

“…They reported that the hyaluronan level increased until adulthood both in the gel and liquid fluid and that after adulthood, hyaluronan remained at the same level in the gel, but increased in the liquid vitreous. Denlinger et al [8 ]obtained liquid vitreous from monkey eyes by aspiration. They concluded that hyaluronan levels in liquid vitreous increased with aging.…”

“…It has been reported that hyaluronan in the skin decreases with aging [6]. However, previous studies show that vitreous hyaluronan increases with aging [7, 8]. These investigators examined intravitreal hyaluronan levels in enucleated animal eyes or autopsy eyes, in which the vitreous sample was obtained by aspiration or by removing the sclera and the uvea.…”