Age-Related Changes in the Reducible Cross-Links of Human Dermis Collagen

Volpin, Dino; Giro, M.G.; Castellani, I.; Peserico, Andrea

doi:10.1159/000250989

Cited by 12 publications

(3 citation statements)

References 7 publications

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“…rall rearrangement of the dermal collagen network may help explam some of the age-related biomechanical and biochem � cal changes. Several investi gators have reported a progressive decrease in the cross-links with maturity, and an absence of these cross-Jinks in aged tissues [47][48][49]. skin, the tensile strength of collagen fibers mcreases and the � km beco � e � less stretchable [44,45].…”

Section: Collagenmentioning

confidence: 99%

Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy

Lavker¹,

Zheng²,

Dong³

1987

Journal of Investigative Dermatology

133

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The fine structural organization of the epidermis, der mal! epidermal junction, and dermis from an unexposed site (upper inner arm) of elderly people was compared with the organization of a similar region of young people. De spite an overall thinning of the epidermis and focal areas of cytologic atypia, the characteristic morphological mark ers associated with the keratinization process are not mark edly altered in appearance or amount. A well-formed stra tum corneum consisting offlattened, enucleated horny cells enveloped by a thickened membrane, and intracellular spaces filled with electron-dense material provide structural evi dence that barrier ability is not compromised in senile skin.The dermal/epidermal changes in aged skin are marked and have significant physiologic implications. The major change is a relatively flat dermal/epidermal junction re sulting from the retraction of the epidermal papillae as well W ith advancing age, the skin and its appendages undergo marked changes. Alterations include in creased roughness, wrinkling, loss of elasticity, mottling, and a general transparency or thinness. In addition, a wide variety of proliferative lesions appear, giving rise to our general perception of an aged individual. These visible changes are noted primarily in exposed skin and represcnt age-related extrinsic effects, rather than intrinsic age related alterations. Because of the dramatic effects that cumulative insults from physical, chemical, and mechanical trauma have on skin, most research in cutaneous gerontology has focused on elucidating environmental changes. Alterations due to intrinsic aging have received less attention. It could be argued that because skin interfaces directly with the environment, all changes are extrinsic. However, by investigating areas that are more protected from environmental insults, certain inferences about the intrinsic aging process can be made. We have chosen the upper inner arm as an area that might closely resemble intrinsically aged skin. This region is relatively shielded from photoaging by its anatomical location, and is further protected by clothing. It does not receive cxcessive chemical insults and does not undergo deformations and reformations induced by pressure, as does skin on the but tocks.

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Section: Collagenmentioning

confidence: 99%

Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy

Lavker¹,

Zheng²,

Dong³

1987

Journal of Investigative Dermatology

133

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“…Subsequently, a similar age-related change in the reducible cross-links of human tendon, bone and cartilage was reported (4,5). Recently, the findings of Bailey and Shimokomaki (1) have been confirmed by Volpin et al (13). To our knowledge there has been no observation on reducible cross-links in human aorta collagen.…”

mentioning

confidence: 58%

“…To our knowledge there has been no observation on reducible cross-links in human aorta collagen. In these studies on human skin no attempt has been made to divide the col lagen into soluble and insoluble fractions pre ceding the evaluation of age-related change in their reducible cross-link (1,6,13). Such a preliminary fractionation of collagen is most important to elucidate the aging process be cause the solubility of human skin and aorta collagens largely decreases with age (11).…”

mentioning

confidence: 99%

Age-Related Change in the Reducible Cross-Link of Human Skin and Aorta Collagens

Shiozawa¹,

Tanaka²,

Miyahara³

et al. 1979

Gerontology

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Age-related changes in the reducible cross-links of soluble and insoluble collagens from the human skin and aorta were evaluated. Histidinohydroxymerodesmosine decreased with age up to the fifth decade and then remained constant in the insoluble skin collagen but could not be detected in the insoluble aorta collagen. Dihydroxylysinonorleucine could be observed, if in a small amount, in the insoluble aorta collagen but not in both the soluble and insoluble skin collagens. Hydroxylysinonorleucine seemed to be present in only a small amount, although coeluting unknown substances made it difficult to evaluate correctly. Two unknown components decreasing with age were found; the one in the insoluble skin collagen and the other in the insoluble aorta collagen. Difference in reducible cross-link was indicated between the skin and aorta collagens.

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Analysis of the Crosslinking Components in Collagen and Elastin

Robins¹

1982

Methods of Biochemical Analysis

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Age-Related Changes in the Reducible Cross-Links of Human Dermis Collagen

Cited by 12 publications

References 7 publications

Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy

Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy

Age-Related Change in the Reducible Cross-Link of Human Skin and Aorta Collagens

Analysis of the Crosslinking Components in Collagen and Elastin

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