Age-Related Changes in Myocardial Relaxation Using Three-Dimensional Tagged Magnetic Resonance Imaging

Oxenham, Helen; Young, Alistair A.; Cowan, Brett R.; Gentles, Thomas L.; Occleshaw, Christopher J.; Fonseca, Carissa G.; Doughty, Robert N.; Sharpe, Norman

doi:10.1081/jcmr-120022258

Cited by 95 publications

(69 citation statements)

References 26 publications

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“…24 However, LV twist increases with advancing age, probably because of subendocardial dysfunction. 9,21,25 The early diastolic release of increased potential energy stored during this augmented systolic twisting deformation may be the cause of the preserved peak diastolic untwisting velocity and untwisting rate with ageing found both in the current study and by Takeuchi et al 9 Our findings of strong, age-independent relationships between LV peak systolic twist and peak diastolic untwisting velocity and untwisting rate support this hypothesis. Nevertheless, although the peak diastolic untwisting velocity and untwisting rate did not change significantly, with advancing age both parameters were impaired when normalized for the increased extent of LV twist.…”

Section: Influence Of Ageing On LV Untwistingsupporting

confidence: 81%

Alterations in Left Ventricular Untwisting With Ageing

Dalen

Soliman

Kauer

et al. 2010

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp nderstanding age-associated changes of the cardiovascular system is important because these changes are an important precursor to cardiovascular disease. 1 Marked changes in left ventricular (LV) diastolic function are known to occur in normal, healthy, older people, 2,3 although the processes contributing to these changes are yet to be fully elucidated. The dynamic interaction of subendocardial and subepicardial fibers causes a twisting LV deformation during systole that leads to storage of potential energy. 4,5 Subsequent rapid untwisting during isovolumic relaxation decreases LV pressure, which makes effective sucking of blood into the LV possible once the mitral valve opens. 6 However, conflicting data have been published on the changes in the untwist rate and, in particular, the peak diastolic untwisting velocity with ageing. [7][8][9][10] In order to gain further insight into age-associated changes of LV diastolic function, the purpose of the current study was to investigate alterations in LV untwisting with ageing. Methods Study ParticipantsThe study population consisted of 75 healthy, non-obese (body mass index <27 kg/m 2 ) volunteers without hypertension, diabetes or regular use of medication for cardiovascular disease, with a normal 12-lead ECG, normal left atrial and LV dimensions, and LV ejection fraction by transthoracic echocardiography. None of the patients had complaints that were compatible with cardiac disease. All patients were required to have good echocardiographic image quality that allowed for complete analysis of LV rotation and twist by speckle-tracking echocardiography. Patients were primarily recruited from our department (personnel) or were family members or friends. The subjects were classified into 3 groups: aged 16-35 (Group 1, n=25), 36-55 (Group 2, n=25) and 56-75 (Group 3, n=25) years. Informed consent was given by all patients and the institutional review board approved the study. EchocardiographyTwo-dimensional grayscale harmonic images were obtained in the left lateral decubitus position using a commercially available ultrasound system (iE33, Philips, Best, The Netherlands) equipped with a broadband (1-5 MHz) S5-1 transducer (frequency transmitted 1.7 MHz, received 3.4 MHz). All echocardiographic measurements were averaged from 3 heartbeats. From the M-mode recordings the following data were acquired: left atrial size, LV end-diastolic septal and posterior wall thicknesses, and LV end-diastolic and end-systolic dimensions. The LV ejection fraction was calculated from Background: In order to gain further insight into age-associated changes of left ventricular (LV) diastolic function, the purpose of the current study was to investigate alterations in LV untwisting with ageing.

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Section: Influence Of Ageing On LV Untwistingsupporting

confidence: 81%

Alterations in Left Ventricular Untwisting With Ageing

Dalen

Soliman

Kauer

et al. 2010

Circ J

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“…The sample size of each group was relatively small (8 to 10 subjects), although the characteristics of LV torsional deformation were clearly demonstrated. LV torsional deformation in elderly people has previously been reported 24 but was not a focus of the present study, although such future data would be very interesting. Detailed examination of LV mechanics by tissue-tagged magnetic resonance imaging showed that infant myocardial angular deformation is not homogeneous in any given short-axis LV plane, 35 although some of this variability may reflect measurement noise.…”

Section: Limitationsmentioning

confidence: 62%

“…Higher fiber stress is associated with enhanced torsion, and in general, fiber stress rises with age in adults, predicting that there should be an age-related rise in torsion. Oxenham et al 24 reported that peak apical rotation and LV torsion were increased in older subjects (69 years) more so than in younger ones (22 years). Our results suggest that LV torsion increases even earlier, as shown in our middle-aged adults (averaging 42 years).…”

Section: Enhanced Lvtor N In Infancy and Middle-age Adultsmentioning

confidence: 99%

Maturational and Adaptive Modulation of Left Ventricular Torsional Biomechanics

et al. 2006

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Background-Left ventricular (LV) torsional deformation, based in part on the helical myocardial fiber architecture, is an important component of LV systolic and diastolic performance. However, there is no comprehensive study describing its normal development during childhood and adult life. Methods and Results-Forty-five normal subjects (25 children and 20 adults; aged 9 days to 49 years; divided into 5 groups: infants, children, adolescents, and young and middle-age adults) underwent assessment of LV torsion and untwisting rate by Doppler tissue imaging. LV torsion increased with age, primarily owing to augmentation in basal clockwise rotation during childhood and apical counterclockwise rotation during adulthood. Although LV torsion and untwisting overall showed age-related increases, when normalized by LV length, they showed higher values in infancy and middle age. The proportion of untwisting during isovolumic relaxation was lowest in infancy, increased during childhood, and leveled off thereafter, whereas peak untwisting performance (peak untwisting velocity normalized by peak LV torsion) showed a decrease during adulthood. Conclusions-We have shown the maturational process of LV torsion in normal subjects. Net LV torsion increases gradually from infancy to adulthood, but the determinants of this were different in the 2 age groups. The smaller LV isovolumic untwisting recoil during infancy and its decline in adulthood may suggest mechanisms for alterations in diastolic function.

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“…This indicates a potential subendocardial dysfunction, which is further associated with reduction in longitudinal shortening observed with physiological aging and hypertrophic cardiomyopathy. 6,7,9 Previous studies also demonstrated a decline in cardiac high-energy phosphate (PCr/ATP ratio) in older individuals. 9,10 This may be because of multiple reasons, such as altered creatine content or the activity of creatine kinase which we cannot determine from these data.…”

Section: Discussionmentioning

confidence: 99%

Effect of Physical Activity on Age-Related Changes in Cardiac Function and Performance in Women

Jakovljevic¹,

Papakonstantinou

Blamire

et al. 2015

Circ: Cardiovascular Imaging

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Background— Higher levels of physical activity are associated with reduced cardiovascular mortality but its effect on age-related changes in cardiac structure and function is unknown. The present study defines the effect of daily physical activity on age-related changes in cardiac structure, function, metabolism, and performance in healthy women. Methods and Results— Sixty-three healthy women were grouped according to age (young, 20–30 years, n=21; middle, 40–50 years, n=22; and older, 65–81 years, n=20) and daily physical activity level (low active <7500 and high active >12 500 steps/d). Participants underwent cardiac MRI including tissue tagging and 31 P spectroscopy and exercise testing with noninvasive central hemodynamic measurements. Aging was associated with increased concentric remodeling ( P <0.01) and left ventricular torsion ( P <0.01), and a decline in diastolic function ( P <0.01), cardiac phosphocreatine:ATP ratio ( P <0.01), peak exercise cardiac power output ( P <0.01), and O 2 consumption ( P <0.01). Older high-active women demonstrated a phosphocreatine:ATP ratio and relative peak O 2 consumption similar to young low-active women, and 23% and 26% higher than older low-active women (phosphocreatine:ATP ratio, 1.9±0.2 versus 1.4±0.1; P <0.05 and O 2 consumption, 24.1±3.8 versus 17.8±2.0 mL/[kg·min]; P <0.01). In older women, physical activity had no effect on eccentricity ratio (0.9±0.2 versus 0.8±0.1 g/mL; P =0.19), E/A ratio (1.3±0.5 versus 1.4±0.5; P =0.66), torsion (7.6±1.7 versus 8.0°±2.1°; P =0.20), and peak cardiac power output (3.4±0.7 versus 3.4±0.8 W; P =0.91). Conclusions— A higher level of daily physical activity preserves cardiac metabolism and exercise capacity with aging but has limited effect on age-related changes in concentric remodeling, diastolic function, and cardiac performance.

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Age-Related Changes in Myocardial Relaxation Using Three-Dimensional Tagged Magnetic Resonance Imaging

Abstract: Tagged MRI is a unique, noninvasive imaging method that can identify significant prolongation and reduction of myocardial relaxation in older compared with young normal individuals.

Cited by 95 publications

References 26 publications

Alterations in Left Ventricular Untwisting With Ageing

Alterations in Left Ventricular Untwisting With Ageing

Maturational and Adaptive Modulation of Left Ventricular Torsional Biomechanics

Effect of Physical Activity on Age-Related Changes in Cardiac Function and Performance in Women

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