Age-related changes in cortical bone in men: metacarpal bone mass measurement study

Iwamoto, Jun; Takeda, Tsuyoshi; Ichimura, Shoichi; Tsukimura, Yasunori; Toyama, Yoshiaki

doi:10.1007/s007760050002

Cited by 13 publications

(4 citation statements)

References 21 publications

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“…It has been generally accepted that peak bone mass at any skeletal site is attained in both sexes during the midthirties. Bone mass decreases significantly with aging both in middle-aged and elderly men and women [ 11 , 12 ]. In present study, the peak vBMD values of the spine were observed at 30 to 39 years in Chinese women and at 20 to 29 years in Chinese men.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Spine and Hip BMD Assessments Derived from Quantitative Computed Tomography

Zhang

Wang

et al. 2015

International Journal of Endocrinology

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Quantification of bone mineral density (BMD) is being used as the main method to diagnose osteoporosis. Dual-energy X-ray absorptiometry (DXA) is the most common tools for measuring BMD. Compared to DXA, quantitative computed tomography (QCT) can determine in three dimensions the true volumetric BMD (vBMD) at any skeletal site. In addition to the spine, the hip is an important site for axial BMD measurement. This study examines lumbar spine and hip BMD of Chinese adults by QCT. Age related changes in bone mass derived by QCT measurements were determined. The osteoporosis QCT detection rates at the spine and hip are assessed in both female and male, and agreement of skeletal status category between the spine and hip in older adults is also assessed.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Spine and Hip BMD Assessments Derived from Quantitative Computed Tomography

Zhang

Wang

et al. 2015

International Journal of Endocrinology

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“…27 Recently, however, we found a significant age-related decrease in metacarpal BMD when very elderly men were included as subjects. 13 This result suggests that significant bone loss can be observed in elderly males with lower levels of testosterone. 8,27 Furthermore, a marked significant increase in urinary NTx levels is observed in women within 5 years after menopause, 9,31,33 while no significant changes in urinary NTx levels are observed with aging in adult males.…”

Section: Discussionmentioning

confidence: 93%

Relationships among physical activity, metacarpal bone mass, and bone resorption marker in 70 healthy adult males

Iwamoto

Takeda

Ichimura

2002

Journal of Orthopaedic Science

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“…(1) Sex-specific differences in the magnitude of periosteal apposition are well documented. (5,10,16,(33)(34)(35)(36)49) Most clinical studies found that women do not add as much bone periosteally as men, and often attributed this phenomenon to intrinsic biological differences or sex-specific differences in physical activity level. (49) We found significant differences in the total area versus age regressions between men and women (Table 1), with men showing greater increases in total area over time compared to women.…”

Section: Journal Of Bone and Mineral Researchmentioning

confidence: 99%

“…The amount of continued periosteal apposition varies with bone site, (9) age, (28,29) and sex. (5,10,16,(33)(34)(35)(36) Although many factors contributing to variation in periosteal apposition have been identified, (9,27,28,(37)(38)(39)(40)(41)(42)(43)(44) a critical but largely neglected factor is bone width. (45) Because bone morphology and strength are nonlinearly related, mathematical models are needed to predict how bone width should change over time to maintain stiffness and strength.…”

Section: Introductionmentioning

confidence: 99%

The amount of periosteal apposition required to maintain bone strength during aging depends on adult bone morphology and tissue-modulus degradation rate

Jepsen

Andarawis‐Puri

2012

Journal of Bone and Mineral Research

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Although the continued periosteal apposition that accompanies age-related bone loss is a biomechanically critical target for prophylactic treatment of bone fragility, the magnitude of periosteal expansion required to maintain strength during aging has not been established. A new model for predicting periosteal apposition rate for men and women was developed to better understand the complex, nonlinear interactions that exist among bone morphology, tissue-modulus, and aging. Periosteal apposition rate varied up to 8-fold across bone sizes, and this depended on the relationship between cortical area and total area, which varies with external size and among anatomical sites. Increasing tissue-modulus degradation rate from 0 to −4%/decade resulted in 65–145% increases in periosteal apposition rate beyond that expected for bone loss alone. Periosteal apposition rate had to increase as much as 350% over time to maintain stiffness for slender diaphyses, whereas robust bones required less than a 32% increase over time. Small changes in the amount of bone accrued during growth (i.e., adult cortical area) affected periosteal apposition rate of slender bones to a much greater extent compared to robust bones. This outcome suggested that impaired bone growth places a heavy burden on the biological activity required to maintain stiffness with aging. Finally, sex-specific differences in periosteal apposition were attributable in part to differences in bone size between the two populations. The results indicated that a substantial proportion of the variation in periosteal expansion required to maintain bone strength during aging can be attributed to the natural variation in adult bone width. Efforts to identify factors contributing to variation in periosteal expansion will benefit from developing a better understanding of how to adjust clinical data to differentiate the biological responses attributable to size-effects from other genetic and environmental factors.

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Age-related changes in cortical bone in men: metacarpal bone mass measurement study

Cited by 13 publications

References 21 publications

Comparison of the Spine and Hip BMD Assessments Derived from Quantitative Computed Tomography

Comparison of the Spine and Hip BMD Assessments Derived from Quantitative Computed Tomography

Relationships among physical activity, metacarpal bone mass, and bone resorption marker in 70 healthy adult males

The amount of periosteal apposition required to maintain bone strength during aging depends on adult bone morphology and tissue-modulus degradation rate

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