Age-related changes in baroreflex control of heart rate and sympathetic nerve activity in healthy humans

Matsukawa, Tetsuya; Sugiyama, Yoshiki; Mano, Tadaaki

doi:10.1016/0165-1838(96)00057-4

Cited by 69 publications

(58 citation statements)

References 14 publications

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“…As established previously, 6,8,13,17,18,23 cardiovagal baroreflex sensitivity was reduced with age in the present study. However, cardiovagal baroreflex sensitivity was not consistently related to baroreflex buffering, although one correlation was observed.…”

Section: Discussionsupporting

confidence: 71%

“…One possibility is that our findings support the hypothesis 20,23 that the age-associated increase in basal sympathetic activity is mediated in part by a reduction in tonic baroreflex suppression of central sympathetic outflow. Although most previous investigations, 6,17 including our own work, 5 have failed to demonstrate differences in the MSNA responses to acute experimental perturbations in blood pressure in young and older healthy adults, these studies did not determine baroreflex buffering per se. Moreover, there are data in experimental animals supporting such a mechanistic association between age-related increases in basal sympathetic activity and reduced tonic baroreflex sympathoinhibition.…”

Section: Discussionmentioning

confidence: 81%

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Baroreflex Buffering Is Reduced With Age in Healthy Men

et al. 2003

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 81%

Baroreflex Buffering Is Reduced With Age in Healthy Men

et al. 2003

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“…Baroreflex control of sympathetic nerve activity was not altered whereas baroreflex control of parasympathetic nerve activity was attenuated by aging in humans. 13 Moreover Laitinen et al 12 confirmed these results in a larger sample of subjects (nϭ63, aged 23 to 77 years) using both the sequence and the cross-spectral determination of BRS for Finapres recordings. Such a result is important to consider because a baroreflex impairment that is the consequence of the decrease of the vagal autonomic function is considered as an independent marker of mortality.…”

Section: Figure 1 Correlations Between Age and S-brs At Inclusion (Asupporting

confidence: 65%

“…10 The decrease in baroreflex buffering with aging was related to an increase in basal sympathetic nerve activity and to a reduction in systemic Alpha1-adrenergic vascular responsiveness whereas the decrease in cardiovagal baroreflex was related to a decrease in parasympathetic pathways. 10,13 However, to our knowledge, the intraindividual BRS alteration with age has never been reported. For that purpose, we analyzed the S-BRS 5-year aging process in a cohort of 205 healthy young men.…”

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confidence: 97%

Aging Process on Spectrally Determined Spontaneous Baroreflex Sensitivity

et al. 2007

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Abstract-The interindividual age-related decrease in baroreflex sensitivity (BRS) was reported in many cross-sectional studies. However, the long-term intraindividual decrease in BRS has never been confirmed by longitudinal studies. Data obtained from a 5-year prospective study designed to assess the 5-year stress effects on blood pressure (BP) provided the opportunity to assess longitudinal aging process on spectrally determined BRS (S-BRS) using the cross spectral analysis. This analysis was carried out in 205 men aged between 18 and 50 years who had 2 valid beat to beat BP recordings (Finapress) at a mean 5-year interval. At inclusion and at end of follow-up, S-BRS was significantly correlated with age (rϭϪ0. 50, PϽ0.001, rϭϪ0.33, PϽ0.001 respectively). Interestingly, the slopes and the intercepts were not significantly different at a 5-year interval. This result is in favor of the good reproducibility of S-BRS. The attenuation with age of S-BRS was calculated at 3.6% a year. This decrease was slightly higher than the one obtained with the baseline data (2.3% per year). This longitudinal study provided, for the first time, an estimate of the slope of the age-related physiological S-BRS decrease in a mid-aged healthy male population. Our findings reinforce the interest of evaluating spontaneous BRS reported to predict hypertension and cardiovascular events in various populations. Key Words: mental stress Ⅲ baroreflex Ⅲ hypertension Ⅲ blood pressure Ⅲ reproducibility B aroreflex sensitivity (BRS) is a relevant index of the autonomic control of blood pressure (BP). Historically, BRS was determined using drug-induced BP and heart rate (HR) opposite variations. More recently, noninvasive techniques of determining spontaneous BRS have been implemented, 1-3 the spectral method being one of the most popular. The spectral determination of BRS (S-BRS) is a reliable measure of BRS because it has often been reported to be correlated with the pharmacologically determined BRS. 4 -7 S-BRS is easy to determine, and repeated measures are easy to make. Aging process on S-BRS has already been reported in several cross sectional studies. 8 -12 Such studies only report interindividual S-BRS variation with age. Thus, S-BRS has consistently been reported to decrease with age. Physiological aging in men was associated with a marked reduction in baroreflex buffering. A differential aging process on baroreflex buffering BP and cardiovagal baroreflex was reported. 10 The decrease in baroreflex buffering with aging was related to an increase in basal sympathetic nerve activity and to a reduction in systemic Alpha1-adrenergic vascular responsiveness whereas the decrease in cardiovagal baroreflex was related to a decrease in parasympathetic pathways. 10,13 However, to our knowledge, the intraindividual BRS alteration with age has never been reported. For that purpose, we analyzed the S-BRS 5-year aging process in a cohort of 205 healthy young men. This unique data set was extracted from a 5-year follow-up study designed to assess stress ...

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“…Moreover, the enhanced pressor response to ANG II in PA patients may also be due to a greater increase in sympathetic neural outflow. Baroreflex sensitivity of the heart rate was reduced in PA patients compared with normal control subjects and the same patients after unilateral adrenalectomy, in agreement with previous studies (16,30). Previous studies showed that intravenous infusion of aldosterone attenuated the baroreflex sensitivity of the heart rate (19,33) and MSNA (19).…”

Section: Discussionsupporting

confidence: 80%

Does infusion of ANG II increase muscle sympathetic nerve activity in patients with primary aldosteronism?

Matsukawa¹,

Miyamoto²

2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Patients with primary aldosteronism (PA) were shown to have suppressed muscle sympathetic nerve activity (MSNA) in our previous study. Although baroreflex inhibition probably accounts in part for this reduced MSNA in PA, we hypothesized that the lowered activity of the renin-angiotensin system in PA may also contribute to the suppressed SNA. We recorded MSNA in 9 PA and 16 age-matched normotensive controls (NC). In PA, the resting mean blood pressure (MBP) and serum sodium concentrations were increased, and MSNA was reduced. We examined the effects of infusion of a high physiological dose of ANG II (5.0 ng ⅐ kg Ϫ1 ⅐ min Ϫ1 ) on MSNA in 6 of 9 PA and 9 of 16 NC. Infusion of ANG II caused a greater pressor response in PA than NC, but, in spite of the greater increase in pressure, MSNA increased in PA, whereas it decreased in NC. Simultaneous infusion of nitroprusside and ANG II, to maintain central venous pressure at the baseline level and reduce the elevation in MBP induced by ANG II, caused significantly greater increases in MSNA in PA than in NC. Baroreflex sensitivity of heart rate, estimated during phenylephrine infusions, was reduced in PA, but baroreflex sensitivity of MSNA was unchanged in PA compared with NC. All the abnormalities in PA were eliminated following unilateral adrenalectomy. In conclusion, the suppressed SNA in PA depends in part on the low level of ANG II in these patients.angiotensin II IT IS UNCLEAR WHETHER OR NOT a neurogenic mechanism is involved in the development and maintenance of elevated blood pressure levels in cases of hypertension induced by mineralocorticoid (2,4,5,9,17,26,29,35). Previous studies in rats (2,4,5,29) demonstrated the importance of the sympathetic nervous system or the central nervous system in the pathogenesis of hypertension caused by an excess of mineralocoticoid; central administration of aldosterone caused hypertension in rats (4, 5). However, recent studies in sheep did not support a role of the brain or the sympathetic nervous system in blood pressure elevation induced by the administration of aldosterone (17,35). Some clinical studies have estimated sympathetic nerve activity during the administration of mineralocorticoid (9, 26) or the nerve activity in patients with primary aldosteronism (PA), a type of human mineralocoticoid hypertension (1,8,18,20). Previous clinical studies, including a direct recording of sympathetic nerve activity in our previous study (18) and power spectral analysis of blood pressure (20), suggested a decrease in sympathetic nerve activity in PA patients. However, no studies on directly recorded sympathetic nerve activity in PA patients exist, or the mechanisms of the abnormality of nerve activity in PA were not clarified.Circulating ANG II has been reported to increase sympathetic nerve activity in animals (24, 27) and humans (11,14). Previous animal studies suggest that ANG II stimulates sympathetic nerve activity via sympathetic ganglia (3, 10, 11) and the central nervous system (24, 27). In our previous human studies with norm...

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Age-related changes in baroreflex control of heart rate and sympathetic nerve activity in healthy humans

Cited by 69 publications

References 14 publications

Baroreflex Buffering Is Reduced With Age in Healthy Men

Baroreflex Buffering Is Reduced With Age in Healthy Men

Aging Process on Spectrally Determined Spontaneous Baroreflex Sensitivity

Does infusion of ANG II increase muscle sympathetic nerve activity in patients with primary aldosteronism?

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