Age-Related Change of the Secretory Flow of Pancreatic Juice in the Main Pancreatic Duct: Evaluation With Cine-Dynamic MRCP Using Spatially Selective Inversion Recovery Pulse

Torigoe, Teruyuki; Ito, Katsuyoshi; Yamamoto, Akira; Kanki, Akihiko; Yasokawa, Kazuya; Tamada, Tsutomu; Yoshida, Kōji

doi:10.2214/ajr.13.10852

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…Age-related morphological changes such as fibrosis in the pancreas have been reported (16). Recently, an interesting report described the pancreatic functional changes with aging (17). After excluding patients with pancreatic disease, it was shown that the frequency and distance of pancreatic juice discharge was negatively related to aging by cine-dynamic magnetic resonance cholangiopancreatography (MRCP).…”

Section: Discussionmentioning

confidence: 99%

Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfunction with the Pathogenesis of Functional Dyspepsia

et al. 2017

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Objective In symptom-dependent diseases such as functional dyspepsia (FD), matching the pattern of epigastric symptoms, including severity, kind, and perception site, between patients and physicians is critical. Additionally, a comprehensive examination of the stomach, duodenum, and pancreas is important for evaluating the origin of such symptoms. Methods FD-specific symptoms (epigastric pain, epigastric burning, early satiety, and postprandial fullness) and other symptoms (regurgitation, nausea, belching, and abdominal bloating) as well as the perception site of the above symptoms were investigated in healthy subjects using a new questionnaire with an illustration of the human body. A total of 114 patients with treatment-resistant dyspeptic symptoms were evaluated for their pancreatic exocrine function using N-benzoyl-L-tyrosyl-p-aminobenzoic acid. Results A total of 323 subjects (men:women, 216:107; mean age, 52.1 years old) were initially enrolled. Most of the subjects felt the FD-specific symptoms at the epigastrium, while about 20% felt them at other abdominal sites. About 30% of expressed as epigastric symptoms were FD-nonspecific symptoms. At the epigastrium, epigastric pain and epigastric burning were mainly felt at the upper part, and postprandial fullness and early satiety were felt at the lower part. The prevalence of patients with pancreatic exocrine dysfunction was 71% in the postprandial fullness group, 68% in the epigastric pain group, and 82% in the diarrhea group. Conclusion We observed mismatch in the perception site and expression between the epigastric symptoms of healthy subjects and FD-specific symptoms. Postprandial symptoms were often felt at the lower part of the epigastrium, and pancreatic exocrine dysfunction may be involved in the FD symptoms, especially for treatment-resistant dyspepsia patients.

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Section: Discussionmentioning

confidence: 99%

Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfunction with the Pathogenesis of Functional Dyspepsia

et al. 2017

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“…Furthermore, the age‐related decrease in flow of pancreatic juice in the main pancreatic duct (Fig. ) has recently been visually confirmed with cine‐dynamic MRCP using spatially selective inversion recovery pulse . In a population‐based German study (SHIP) of almost 1000 healthy individuals with normal serum lipase and amylase, there was a significant 30% reduction in secretin‐stimulated output in those over 80 years old .…”

Section: Systematic Literature Review Of Age‐related Pancreatic Functmentioning

confidence: 99%

The ageing pancreas: a systematic review of the evidence and analysis of the consequences

et al. 2018

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Senior people constitute the fastest growing segment of the population. The elderly are at risk for malnutrition, thought to be caused by reduced food intake or involution of the physiological capacity of the GI tract. Age-related changes are well known in other secretory organs such as liver, kidney and intestine. The pancreas, representing a metabolically active organ with uptake and breakdown of essential nutritional components, changes its morphology and function with age. During childhood, the volume of the pancreas increases, reaching a plateau between 20 and 60 years, and declines thereafter. This decline involves the pancreatic parenchyma and is associated with decreased perfusion, fibrosis and atrophy. As a consequence of these changes, pancreatic exocrine function is impaired in healthy older individuals without any gastrointestinal disease. Five per cent of people older than 70 years and ten per cent older than 80 years have pancreatic exocrine insufficiency (PEI) with a faecal elastase-1 below 200 μg g stool, and 5% have severe PEI with faecal elastase-1 below 100 μg g stool. This may lead to maldigestion and malnutrition. Patients may have few symptoms, for example steatorrhoea, diarrhoea, abdominal pain and weight loss. Malnutrition consists of deficits of fat-soluble vitamins and is affecting both patients with PEI and the elderly. Secondary consequences may include decreased bone mineral density and results from impaired absorption of fat-soluble vitamin D due to impaired pancreatic exocrine function. The unanswered question is whether this age-related decrease in pancreatic function warrants therapy. Therapeutic intervention, which may consist of supplementation of pancreatic enzymes and/or vitamins in aged individuals with proven exocrine pancreas insufficiency, could contribute to healthy ageing.

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“…24 Other reports have shown the incidence of EPI in the elderly to be as high as 21.6%. 25 Torigoe et al 26 the results of which showed that duodenal fluid production after the stimulation rose markedly with increase in age, up to 43 years, and then began to decline. 28 Bicarbonate production began to increase, along with increase in age, up to 34 years of age, and then began to decline.…”

Section: E Xo Crine Fun C Ti Onmentioning

confidence: 99%

“…Torigoe et al used dynamic magnetic resonance imaging of pancreatic biliary flow to evaluate the relationship between pancreatic exocrine function and aging. A total of 53 subjects were divided into three groups based on age (<40, 40‐70 and >70 years old).…”

Section: Exocrine Functionmentioning

confidence: 99%

Pancreatic senescence and its clinical manifestations

Wang

Zheng

2020

Aging Medicine

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The pancreas is a vital organ which has both endocrine and exocrine functions and plays an essential role in food digestion and glucose metabolism. Pancreatic structure and function undergo a series of changes with aging and senescence. Pancreatic exocrine and endocrine function gradually change, which may lead to conditions such as dyspepsia and diabetes mellitus. Hence, clinicians need to be familiar with the characteristics of pancreatic senescence. This article reviews the manifestations of pancreatic senescence and its significance for clinical practice.

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Age-Related Change of the Secretory Flow of Pancreatic Juice in the Main Pancreatic Duct: Evaluation With Cine-Dynamic MRCP Using Spatially Selective Inversion Recovery Pulse

Abstract: Cine-dynamic MRCP using spatially selective IR pulse was able to show the age-related decrease of the secretory flow of pancreatic juice in the main pancreatic duct visually and noninvasively.

Cited by 23 publications

References 23 publications

Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfunction with the Pathogenesis of Functional Dyspepsia

Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfunction with the Pathogenesis of Functional Dyspepsia

The ageing pancreas: a systematic review of the evidence and analysis of the consequences

Pancreatic senescence and its clinical manifestations

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