Age, pelvic incidence, facet joint angle and pedicle-facet angle as correlative factors for isthmic spondylolisthesis: a retrospective case control study

Abstract

Background Isthmic spondylolisthesis (IS) is a common clinical disease with a high incidence rate. However, most current researches explain the clear pathogenesis from a single perspective. The aim of our study was to explore the relationships between multiple parameters in patients and find the potential risk factors of this disease. Methods Our study retrospectively included 115 patients who were diagnosed with isthmic spondylolisthesis and the same number of individuals without spondylolisthesis. The following parameters were measured or collected: age, pelvic incidence (PI), facet joint angle (FJA) and pedicle-facet angle (P-F angle). The radiographic files were imported into Mimics Medical 20.0 and all collected data were analyzed using SPSS, version 26.0, statistical software. Results The age was higher in IS group than in control group. PI was also higher in the IS group (50.99 ± 7.67) than in the control group (43.77 ± 9.30) significantly (P = 0.009). There was significant difference in cranial and average FJA tropism in L3-L4 level (P = 0.002, P = 0.006, respectively) and in L4-L5 level (P < 0.001). P-F angle of L4-L5 level showed significantly larger in IS group than in control group (P = 0.007).The logistic regression analysis showed a larger age, a greater L3-L4 cranial FJA tropism, and a greater L4-L5 cranial FJA tropism were potential predictors of IS, with an OR of 1.07, 1.28, and 1.39 respectively. The thresholds of the predictors were 60 years, 5.67°, and 8.97° according to the ROC curve. The linear regression equation was established: degree of slippage (%) = 0.220*age − 0.327* L3-4 cranial FJA tropism − 0.346* L4-5 average FJA tropism (F = 3.460, P = 0.011, r = 0.659). Conclusions Our study revealed that isthmic spondylolisthesis may be related to multiple factors rather than a single factor. Age, PI, PJA and P-F angle are potentially associated with spondylolisthesis.

Incidence and risk factors associated with superior segmented facet joint violation in posterior approach lumbar interbody fusion

“…The result of our study was the same as this of Park et al This may be more in line with reality because, as mentioned earlier, facet angle and facet joint hypertrophy were the main in uencing factors of FJV, and patients with isthmic lumbar spondylolisthesis tend to have a larger facet angle [ 20 ], whereas facet angle tend to be smaller in degenerative lumbar spondylolisthesis, because the development of degenerative lumbar spondylolisthesis was associated with smaller facet angle [ 21 , 22 ]. Interestingly, in our study, isthmic lumbar spondylolisthesis had the highest probability of facet joint hypertrophy, and degenerative lumbar spondylolisthesis had the highest probability of high-grade facet joint degeneration (Weishaupt grade ≥2), that is, patients with degenerative lumbar spondylolisthesis had more severe subarticular bone erosion osteophytes, which may be related to the different biomechanical changes resulting from the two different structural alterations, while the speci c reasons need more and more in-depth studies (Table 5).…”

Evaluation of Sacrum Measurements in Healthy Individuals and Patients with L5-S1 Spondylolisthesis

“…It is considered one of the major causes of low back pain among the elderly and is a major cause of spinal canal stenosis associated with low back and leg pain [16]. Kong et al [17] reported that the mean value of age was significantly higher in individuals with spondylolisthesis and that there was a positive correlation between age and spondylolisthesis.…”

Erector spinae could be the game changer in surgical decision-making in patients with lumbar spondylolisthesis: a cross-sectional analysis of an age-, sex-, subtype-, level-matched patients with similar spinopelvic parameters received surgical or conservative management

“…Andrade et al [44] conducted an epidemiologic systematic review of 15 published observational studies analyzing any association between IS and clinical of the pars interarticularis [28]. Even though many factors have been proposed for the etiology of DS and IS, the exact triggers for the onset and progression of spondylolisthesis are still unclear [29][30][31]. Lumbar DS could cause low back pain (LBP) and leg symptoms (neurogenic claudication) due to the slippage and concomitant lumbar spinal stenosis, respectively [27].…”

“…A recent meta-analysis reported that demographic and radiological factors including female sex, body mass index, menopause, early IVDD, sagittal facet joint orientation, joint laxity, high pelvic incidence, presence of spondylolisthesis at L4-L5 level, increased L4 or L5 vertebral angle, increased lumbar I axis sacral I distance, increased lumbar lordotic angle, and having more than 25% slippage were associated with the symptoms of DS [31,[45][46][47][49][50][51][52][53][54][55]. It has been shown that age, pelvic incidence, facet joint angle, and pedicle facet angle were associated with IS [29]. To overcome those confounders, our patients were matched in terms of age, sex, lumbar lordosis, pelvic incidence, subtype (DS or IS) and Meyerding grade of their spondylolisthesis.…”