Age of testing as a factor in the behavioral effects of early lead exposure in rats

Rosen, Jeffrey B.; Berman, Robert F.; Beuthin, Frederic C.; Louis-Ferdinand, Robert T.

doi:10.1016/0091-3057(85)90129-7

Pharmacology Biochemistry and Behavior

1985

DOI: 10.1016/0091-3057(85)90129-7

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Age of testing as a factor in the behavioral effects of early lead exposure in rats

Jeffrey B. Rosen¹,

Robert F. Berman²,

Frederic C. Beuthin³

et al.

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Cited by 11 publications

(1 citation statement)

References 26 publications

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“…The difficulty in comparing these studies is due to the lack of brain and/or blood lead determinations in some of them (Alfano & Petit 1981;Dolinsky et al 1983;Baraldi et al 1988). Further comparison is not possible when lead exposure is associated Author for correspondence: A. L. S. Rodrigues with undernutrition or gross morphological changes, which was often the case in the first reports on lead behavioural effects, and still found in a few studies from the last decade (Sauerhoff & Michaelson 1973;Rosen et al 1985;Draski et al 1989;Hahn et al 1991).…”

mentioning

confidence: 99%

Effect of Perinatal Lead Exposure on Rat Behaviour in Open‐Field and Two‐Wky Avoidance Tasks

Rodrigues

Rocha

Mello

et al. 1996

Pharmacology & Toxicology

125

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In view of conflicting results in literature concerning lead exposure associated with behavioural alterations, this study investigated behaviour in the open-field and shuttle avoidance, for as well as tissue lead burdens of pre- and postnatally lead-exposed rats. Rats were exposed to the metal from conception to weaning by giving the dams 0.5, 2.0 or 4.0 mM lead acetate in drinking water. This regimen did not affect body weight gain of dams or offspring development and had no effect on cerebral weights nor on haematological parameters of 23-day-old rats. In 1-day-old rats, lead accumulated in the blood but not in the brain, whereas both in 23-day-old rats and in dams lead accumulated in blood, kidney and cerebral cortex. In the open-field, lead-exposed groups showed higher locomotor activity in the test session as compared to controls and did not show any decrease in rearing responses in the test, indicating less habituation. Lead-treated rats subjected to a shuttle avoidance task showed no significant increase in avoidance responses between sessions as compared to control, indicating less retention. Moreover, only the control group presented a significant reduction of the footshock escape latency along testing session, suggesting a lead effect on footshock escape acquisition. In the shuttle box, intertrial crossing responses were not affected by lead treatment. The behavioural alterations occurred in animals with blood lead levels in the range 11-50.6 micrograms/dl.

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mentioning

confidence: 99%

Effect of Perinatal Lead Exposure on Rat Behaviour in Open‐Field and Two‐Wky Avoidance Tasks

Rodrigues

Rocha

Mello

et al. 1996

Pharmacology & Toxicology

125

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Effects of 1.2 μM lead in the laboratory mouse: Developmental and behavioural consequences of chronic treatment

Donald

Cutler

1986

Neuropharmacology

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Discriminative stimulus properties of amphetamine and other stimulants in lead-exposed and normal rats

Rosen

Young

Beuthin

et al. 1986

Pharmacology Biochemistry and Behavior

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Age of testing as a factor in the behavioral effects of early lead exposure in rats

Cited by 11 publications

References 26 publications

Effect of Perinatal Lead Exposure on Rat Behaviour in Open‐Field and Two‐Wky Avoidance Tasks

Effect of Perinatal Lead Exposure on Rat Behaviour in Open‐Field and Two‐Wky Avoidance Tasks

Effects of 1.2 μM lead in the laboratory mouse: Developmental and behavioural consequences of chronic treatment

Discriminative stimulus properties of amphetamine and other stimulants in lead-exposed and normal rats

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