Age of onset of recurrent respiratory papillomatosis: a distribution analysis

Abstract

Distribution of age of onset of RRP shows three peaks. In addition to the already adopted idea of age peaks at paediatric and adult age, there is an additional peak around the age of 64.

Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis—A South African perspective

“…In our population, the majority of patients, 78.1% (82/105), were younger than 18 years old, with 21.9% older than 18 years. This is in contrast to the data reported by San Giorgi et al, where these proportions are almost exactly reversed: 18% of patients younger than 18 years, and 82% older . Thus, in our sample, we have relatively little information on the distribution of age of diagnosis of AoRRP, and it is therefore not surprising that the best fitting mixture model for our data has only two components.…”

“…The age distribution of our patient population differs significantly from that of San Giorgi et al . In our population, the majority of patients, 78.1% (82/105), were younger than 18 years old, with 21.9% older than 18 years.…”

“…Traditionally, a bimodal distribution of age of diagnosis has been described, in keeping with the two forms of the disease. More recently, a trimodal distribution of age of diagnosis has been reported, with peaks at 7 years, 35 years and 68 years . In this study, which only included data from European centres, the majority of patients were adults.…”

“…In the manner of San Giorgi et al, single, two and three component mixtures were fitted to the data to estimate the distribution of the age of diagnosis of RRP, alternatively based on the normal and the log‐normal distribution using the SAS procedure FMM, and the Bayesian Information Criterion (BIC) was used to select the best fitting mixture distribution…”

Quality of life of patients with recurrent respiratory papillomatosis

“…As there is still no curative treatment for the disease, and patients go through repetitive surgical removal of the papillomas . RRP has three peaks in incidence around the age of 7, 35, and 64 years and can remain active for decades . The disease is traditionally separated into juvenile‐onset RRP (JoRRP, onset before 18 years of age) and adult‐onset RRP (AoRRP, onset at age 18 years or older).…”