Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis—A South African perspective

Seedat, Riaz Y.; Schall, Robert

doi:10.1111/coa.13016

Cited by 22 publications

(17 citation statements)

References 18 publications

(37 reference statements)

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“…1 Two clinical presentations of the disease are recognizedjuvenile-onset RRP (JoRRP), where the condition occurs under 12 years of age, and adult-onset RRP (AoRRP). JoRRP predominates in sub-Saharan Africa, [2][3][4] in contrast to Europe and South America, where AoRRP predominates. 5,6 Epidemiology The incidence and prevalence of JoRRP in developing countries has been found to be similar to or slightly higher than that in developed countries (Table 1).…”

Section: Introductionmentioning

confidence: 93%

“…Patients generally present between the age of 2 and 6 years, with an approximately equal sex distribution. 2,4,7,16,[30][31][32][33][38][39][40] Patients with HPV11 disease present at a significantly younger age than those with HPV6 disease. 2,20,21,27 The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…2,4,7,16,[30][31][32][33][38][39][40] Patients with HPV11 disease present at a significantly younger age than those with HPV6 disease. 2,20,21,27 The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress. 4,29,30,[38][39][40][41] Patients may be aphonic with respiratory distress on presentation.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…5,6 Epidemiology The incidence and prevalence of JoRRP in developing countries has been found to be similar to or slightly higher than that in developed countries (Table 1). 2,[7][8][9][10][11][12][13][14][15][16] However these data are probably an underestimate as a result of patients not having symptoms severe enough to present, or dying as a result of upper airway obstruction prior to presentation.…”

Section: Introductionmentioning

confidence: 99%

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<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Seedat

2020

PHMT

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Recurrent respiratory papillomatosis (RRP) is a condition caused by human papillomavirus (HPV), usually HPV types 6 and 11, which is characterized by recurrent papillomas of the respiratory tract, mainly the larynx. Patients usually present between the ages of 2 and 6 years. The initial presenting symptom is progressive dysphonia, followed by stridor and respiratory distress. Treatment consists of repeated microlaryngoscopic procedures to remove the papillomas as there is no cure. The poor availability and accessibility of appropriate healthcare services in developing countries are barriers to the early diagnosis and appropriate management of patients with juvenile-onset recurrent respiratory papillomatosis (JoRRP), requiring many patients to have a tracheostomy. The introduction of prophylactic vaccines that include HPV6 and HPV11 is necessary in order to reduce the incidence of JoRRP.

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Section: Introductionmentioning

confidence: 93%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Seedat

2020

PHMT

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“…Common pediatric infections such as peritonsillar abscess and juvenile‐onset laryngeal papillomata have a similar prevalence in sub‐Saharan Africa as compared to the United States; however, these patients often present to the hospital in distress with severe airway obstruction . Such cases in inexperienced hands or poorly equipped settings can be life threatening.…”

Section: Common Causes Of the Pediatric Difficult Airway In Lmicsmentioning

confidence: 99%

Adaptations in pediatric anesthesia care and airway management in the resource‐poor setting

Manyumwa

Chimhundu-Sithole

Marange-Chikuni

et al. 2020

Pediatric Anesthesia

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The need for safe and quality pediatric anesthesia care in low‐ and middle‐income countries (LMICs) is huge. An estimated 1.7 billion children do not have access to surgical care, and the majority are in LMICs. In addition, most LMICs do not have the requisite surgical workforce including anesthesia providers. Surgery is usually performed at three levels of facilities: district, provincial, and national referral hospitals. Unfortunately, the manpower, equipment, and other resources available to provide surgical care for children vary greatly at the different level facilities. The majority of district level hospitals are staffed solely by non‐physician anesthesia providers with variable training and little support to manage complicated pediatric patients. Airway and respiratory complications are known to account for a large portion of pediatric perioperative complications. Management of the difficult pediatric airway pathology is a challenge for anesthesia providers regardless of setting. However, in the low‐resource setting poor infrastructure, lack of transportation systems, and crippled referral systems lead to late presentation. There is often a lack of pediatric‐sized anesthesia equipment and resources, making management of the local pathology even more challenging. Efforts are being made to offer these providers additional training in pediatric anesthesia skills that incorporate low‐fidelity simulation. Out of necessity, anesthesia providers in this setting learn to be resourceful in order to manage complex pathologies with fewer, less ideal resources while still providing a safe anesthetic.

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Recurrent Respiratory Papillomatosis

Dikkers

Seedat

Giorgi

2022

Textbook of Surgery of Larynx and Trachea

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Age of diagnosis, incidence and prevalence of recurrent respiratory papillomatosis—A South African perspective

Abstract: Recurrent respiratory papillomatosis in the Free State province of South Africa is a disease with a predominantly juvenile onset, with AoRRP having a lower prevalence than in Europe. This is probably reflective of the situation in sub-Saharan Africa.

Cited by 22 publications

References 18 publications

<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

<p>Juvenile-Onset Recurrent Respiratory Papillomatosis Diagnosis and Management – A Developing Country Review</p>

Adaptations in pediatric anesthesia care and airway management in the resource‐poor setting

Recurrent Respiratory Papillomatosis

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