Age of Onset in Cluster Headache: the Clinical Spectrum (Three Case Reports)

Evers, Stefan; Frese, A.; Majewski, A; Albrecht, Oliver; Husstedt, IW

doi:10.1046/j.1468-2982.2002.00320.x

Cited by 44 publications

(42 citation statements)

References 14 publications

(19 reference statements)

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“…In this patient, the inefficacy of acetylsalicylic acid for cluster attacks should be emphasised, in agreement with a previous report of two cases of childhood cluster headache [18]. One of the few treatment options in this case could be oxygen, which sufficiently controlled CH attacks in an affected child [24]. The younger CH patient identified in our study did not use oxygen, and therefore its efficacy could not be verified.…”

Section: Discussionsupporting

confidence: 83%

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Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Gallai¹,

Mazzotta²,

Floridi³

et al. 2003

J Headache Pain

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A multicenter one-year study was carried out on 6629 headache patients under 18 years of age, attending 27 centers and clinics devoted to headache in Italy to identify the prevalence of cluster headache (CH) in childhood and adolescence. Two male CH patients aged 9 and 17 years were identified. Their attacks fulfilled the IHS criteria for CH, and they were classified as having cluster headache with undetermined periodicity and episodic cluster headache, respectively. The one-year prevalence in this headache out-patient population under 18 years of age was calculated to be 0.03%. This value is smaller than that derived in the general population. This finding further confirms the rarity of early diagnosis of this primary disorder in childhood and adolescence, as demonstrated in other studies.

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Section: Discussionsupporting

confidence: 83%

“…Furthermore, Garrido et al [23] reported a 5-year-old child with cluster headache starting at age 3 years. There are also additional reports in the literature of onset in early childhood with the youngest patients being 3 and 4 years old [24,25].…”

Section: Discussionmentioning

confidence: 99%

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Gallai¹,

Mazzotta²,

Floridi³

et al. 2003

J Headache Pain

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show abstract

“…While most patients present their first features around the third de cade of life, the probands in this study had their initial symp toms about a decade later. The findings of the two patients who began complaining of CH symptoms at an uncommon age (11 and 70 years) are noteworthy, although similar cases have been previously reported 19 . The proportion of episodic and chronic patterns of CH in this sample (approximately 4:1) is also concordant with most studies 20 .…”

Section: Discussionsupporting

confidence: 81%

Familial aggregation of cluster headache

Cruz

Lemos

Monteiro

2013

Arq. Neuro-Psiquiatr.

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Several studies suggest a strong familial aggregation for cluster headache (CH), but so far none of them have included subjects with probable cluster headache (PCH) in accordance with the International Classification of Headache Disorders. Objective: To identify cases of probable cluster headache and to assess the familial aggregation of cluster headache by including these subjects. Method: Thirty-six patients attending a headache consultation and diagnosed with trigeminal autonomic headaches were subjected to a questionnaire-based interview. A telephone interview was also applied to all the relatives who were pointed out as possibly affected as well as to some of the remaining relatives. Results: Twenty-four probands fulfilled the criteria for CH or PCH; they had 142 first-degree relatives, of whom five were found to have CH or PCH, including one case of CH sine headache. The risk for first-degree relatives was observed to be increased by 35-to 46-fold. Conclusion: Our results suggest a familial aggregation of cluster headache in the Portuguese population.Keywords: cluster headache, probable cluster headache, familial aggregation, cluster headache sine headache, first-degree relatives. REsumoDiversos artigos sugerem uma significativa agregação familiar da cefaleia em salvas (CH) embora nenhum tenha incluído indivíduos com provável cefaleia em salvas (PCH), segundo critérios da Classificação Internacional de Cefaleias (ICHD-II). Objetivo: Encontrar casos de provável cefaleia em salvas e avaliar a agregação familiar da cefaleia em salvas incluindo também esses indivíduos. Método: Foi aplicado um questionário por telefone a 36 doentes que frequentaram uma Consulta de Cefaleias com diagnóstico de cefaleia trigémino-autonómica. Todos os familiares de primeiro grau referidos como possivelmente afetados e alguns dos restantes foram entrevistados por telefone. Resultados: Em 24 doentes foi diagnosticada CH ou PCH e estes tinham 142 familiares de primeiro grau, cinco dos quais foram diagnosticados como CH ou PCH, incluindo um caso de CH sem cefaleias. O risco para familiares de primeiro grau foi 35-46 vezes superior ao da população geral. Conclusão: Nossos resultados sugerem a existência de uma agregação familiar da cefaleia em salvas na população portuguesa.Palavras-chave: cefaleia em salvas, provável cefaleia em salvas, agregação familiar, cefaleia em salvas sem cefaleia, familiares de primeiro grau.

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“…The broadest case series in the literature indicates a mean age at onset of about 30 years [1][2][3][4]. Recently, however, anecdotal cases [5][6][7] and small case series [4,8,9] have been reported that seem to suggest onset in old age, especially among women. As data on this subject are still scanty and conflicting, we thought it advisable to review our broad series of CH cases to evaluate: (a) the mean age at onset by gender and CH subtype (episodic and chronic); and (b) any clinical differences in CH patients related to age at onset.…”

Section: Introductionmentioning

confidence: 99%

Late-onset cluster headache: some considerations about 73 cases

et al. 2012

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Data in the literature on cluster headache (CH) indicate a mean age at onset of about 29-30 years; recently, however, cases have been reported with onset in old age. A review of age at onset in all CH patients (n = 693) followed at the University of Parma Headache Centre between 1976 and 2011 shows that 73 (10.5 %) patients began to suffer from CH after age 50. In these 73 patient, the gender (M:F) ratio was 1.4:1, while in the 620 patients with CH onset before age 50, it was 2.5:1. In the patients with CH onset after and before age 50, respectively, the distribution by CH subtype shows that the episodic-to-chronic ratio was 7.6:1 and 7.9:1 in men and 1.5:1 and 7.8:1 in women. In episodic CH men with onset after 50 the average duration of active periods was 60 versus 39 days for those with onset before 50. In women, the duration was 80 and 42 days, respectively. In conclusion, our case review suggests that CH onset after age 50 is not rare, especially in women. Additionally, late onset represents a negative prognostic factor because, particularly in women, CH will more likely be a chronic form and even in episodic forms active periods will last longer.

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Age of Onset in Cluster Headache: the Clinical Spectrum (Three Case Reports)

Cited by 44 publications

References 14 publications

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Cluster headache in childhood and adolescence: one-year prevalence in an out-patient population

Familial aggregation of cluster headache

Late-onset cluster headache: some considerations about 73 cases

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