Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer: A Single-Institutional Analysis in Saudi Arabia

Abstract

Background. This study was undertaken to evaluate the impact of prognostic factors on the locoregional failure-free survival of early breast cancer patients. Methods. In this single-institutional study, 213 breast cancer patients were retrospectively analysed. Fifty-five of 213 patients were ≤40 years of age at diagnosis. The impact of patient- or treatment-related factors on the locoregional failure-free survival was assessed using the Kaplan-Meier method. The simultaneous impact of factors on the locoregional failure-free survival was assessed using the Cox proportional hazards regression analysis. Results. The median follow-up time of the censored patients was 22 months (mean 28 months, range 3–92 months). On univariate analysis, statistically significant factors for the locoregional failure-free survival were the age (≤40 versus >40 years), T stage (Tis, T0–2 versus T3-4), molecular tumor type (luminal A versus luminal B, Her2neu overexpression, or triple negative), and lymphovascular status (LV0 versus LV1). On multivariate analysis, age and T stage remained statistically significant. Conclusions. Being 40 years or younger has a statistically significant independent adverse impact on the locoregional failure-free survival of patients with early breast cancer.

Retrospective Study Assessing Breast Cancer Occurrence and its Risk Factors among Females at Al Ahsa

“…They compared the features and management outcomes between younger and older age clusters, and the study showed being more youthful (age<or=40) to be an independent hazard element for BC relapse. Another research reviewed the epidemiology of BC cases in eastern province and they found that BC cases were detected at earlier age (<50 years: 57.5%) [16]. Other studies in different region in the kingdom and at different period reported the same range of age.…”

“…A selective literature review was done with the intention of providing information to enrich knowledge for the organization of screening, treatment, and preventative approaches for BC in KSA [21]. Other studies [16,[22][23][24][25][26] considered the risk factors of BC. Early identification of breast cancer is crucial and needs special attention.…”

“…Related to the same region, a study in Dammam from 1997 to 2007 mentioned that 31.08 % of cases were diagnosed with malignant BC [16]. A recent study in Al Khobar reported that more women were diagnosed with BC in advanced stages as compared to women in other countries such as the United States [16].…”

“…Related to the same region, a study in Dammam from 1997 to 2007 mentioned that 31.08 % of cases were diagnosed with malignant BC [16]. A recent study in Al Khobar reported that more women were diagnosed with BC in advanced stages as compared to women in other countries such as the United States [16]. Finally in a histopathology record review in Al Ahsa between 2001 and 2007, they found that a benign lesion was common (60.1%) in relation to 21.4% malignancy and 18.5% inflammatory lesion [17].…”

História reprodutiva e sexual de mulheres tratadas de câncer de mama

“…Observa-se, então, que cerca de um terço à metade da população feminina afetada pela doença tem menos de 50 anos, e aproximadamente 10% tem menos de 40 anos 14,15 . O acometimento de mulheres mais jovens pelo câncer de mama parece ser, isoladamente, um fator de mau prognóstico (elevando a chance de recidiva loco regional 16 ), trazendo para essas mulheres uma nova necessidade de planejamento de vida, como a preocupação com a preservação da fertilidade (que pode ser afetada pela doença e pelos tratamentos) 14,15 .…”