Age-induced changes in the aortas of rats

Kojimahara, Masayasu

doi:10.1016/s0232-1513(85)80008-6

Cited by 5 publications

(4 citation statements)

References 13 publications

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“…Many researchers who studied the adaptation of aortic structure to chronic exercise training have used laboratory rats, 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 and important information has emerged from these studies. The presence of smooth muscle, collagen, and elastic fibers in the aortic wall 1 , 2 , 3 , 4 , 5 , 6 gives greater plasticity to the vessel wall, revealed by its capacity to produce a structural response to different conditions. One such condition is physical training that promotes morphological changes to its structure.…”

Section: Introductionmentioning

confidence: 99%

Resistance training improves aortic structure in Wistar rats

Souza

França

Madureira

et al. 2017

Brazilian Journal of Physical Therapy

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Section: Introductionmentioning

confidence: 99%

Resistance training improves aortic structure in Wistar rats

Souza

França

Madureira

et al. 2017

Brazilian Journal of Physical Therapy

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“…These alterations characterize the arterial stiffness. When examined with the electron microscope, important changes were found mainly in the tunica media (Kojimahara, 1985). These changes can ultimately result in aortic stiffening, which impairs the buffering capacity in relation to arterial pressure and flow, contributing to systolic hypertension and an increased cardiac after load (Belz, 1995;Kass, Saeki, Tunin, & Recchia, 1996).…”

Section: Introductionmentioning

confidence: 99%

Resistance training attenuates the effects of aging in the aorta of Wistar rats

Souza

Santos

Maifrino

et al. 2015

Motriz: rev. educ. fis.

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Abstract--The objective of the present study was to follow the structural modifications of the aortic wall in middle-aged rats submitted to a resistance training protocol for a period of four months. Three groups of 8 animals per group were considered: middle-aged group (MA), old control group (OC) and old trained group (OT). Training consisted in to climb a 1.1-m vertical (80° incline) ladder with weights tied to their tail. Aortic wall structural modifications were studied through light and electron microscopy and morphometry. The mean arterial blood pressure at rest was similar in the three experimental groups (p = .07). At the beginning of the experiment, the OC and OT groups had similar repetition maximums, ranging from 1.6-fold to 1.9-fold the body weight. At the end of the experiment, the repetition maximum of the OT group was 5-fold greater than the body weight (p = .03). The LV weight was 15% larger in the OT group than in the MA group and 12% larger than in the OC group (p = .02). The LV wall thickness of the OT group was significantly larger than that of both, the MA group and the OC group (p = .03). The LV internal diameter in the OT group was significantly smaller than that observed in the MA and OC groups (p = .02). Resistance training diminished the alterations associated with aging improving aortic wall structure by reducing the thickness, normalising the elastic material, the collagen and the smooth muscle cells. Resistance training seems to be a potential treatment for reducing the deleterious effects of aging on the aortic wall.Keywords: aortic structure, anaerobic training, remodeling, stereology Resumo--"O treinamento resistido atenua os efeitos do envelhecimento na aorta de ratos Wistar." Este estudo teve por objetivo avaliar as modificações da parede da aorta de ratos Wistar de meia-idade, submetidos a treinamento resistido por 4 meses. Foram utilizados 3 grupos de animais com oito animais por grupo: meia idade (MI), idoso controle (IC) e idoso treinado (IT). Os ratos subiam uma escada vertical inclinada (80°) com pesos atrelados à cauda. A parede da aorta foi avaliada através de microscopia de luz e eletrônica e morfometria. A pressão arterial média no repouso foi similar nos três grupos experimentais (p = 0,07). No início, os grupos IC e IT tiveram treinamento de repetições máximas semelhantes, variando de 1,6 a 1,9 vezes o valor do peso corporal. No final o treinamento de repetição maxima do grupo IT foi 5 vezes maior que o peso corporal (p = 0,03). O peso do ventrículo esquerdo do grupo IT foi 15% maior do que o do grupo MI e 12% maior do que o do grupo IC (p = 0,02). A espessura da parede do ventrículo no grupo IT foi significantemente maior do que nos grupos MI e IC (p = 0,03). O diâmetro interno da cavidade do ventrículo foi significantemente menor no grupo IT do que nos demais grupos (p = 0,02). O treinamento diminuiu as alterações associadas com o envelhecimento melhorando a estrutura da parede da aorta através da redução da sua espessura, normalização quantitativa do material elá...

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“…L'observation ultrastructurale des CML âgées montre aussi une évolution du phénotype des cellules dont l'ergastoplasme et l'appareil de Golgi sont bien développés, ce qui suggère une activité métabolique intense correspondant au phénotype dit "sécréteur" (Cliff, 1970). Cette activité aurait pour conséquence une production accrue de protéines fibrillaires extracellulaires, telles que le collagène ou l'elastine, et pourrait expliquer l'épaississement et la diminution de l'élasticité de ces artères (Cliff, 1970;Dahl, 1976;Goyal, 1982;Kojimahara et Ooneda, 1981;Kojimahara, 1985)). Il est caractéristique que chez l'animal âgé, la taille des CML augmente, leur contour devient de plus en plus irrégulier, leurs prolongements sont souvent ramifiés (Cliff, 1970).…”

Section: Vieillissementunclassified

“…Ce processus augmente considérablement la surface cellulaire, ce qui pouvait favoriser l'échange de metabolites au niveau de ces cellules hypertrophiées (entourées notamment de protéines fibreuses extracellulaires). On observe également des cellules nécrosées ou en voie de dégénérescence, ce qui explique en partie la diminution de la densité cellulaire et l'aspect "fibreux" des artères vieillies (Cliff, 1970;Guyton et coll., 1983;Kojimahara et Ooneda, 1981;Kojimahara, 1985).…”

Section: Vieillissementunclassified

Donnees Anatomophysiologiques en Faveur d'UN Role Non Vasomoteur De l'INNERVATION Autonome Des Vaisseaux Cerebraux: - Role Trophique Au Cours Du Developpementet De l'AGE Adulte. - Possibilite d'UNE Intervention Indirecte Par l'INTERMEDIAIRE De Cellules Adventicielles

Δημητριαδου¹

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noradrénergique pendant la vie adulte 45 4.2.1. Les récepteurs 4.2.2. Réactivité des vaisseaux "in vitro" 4.2.3. Réactivité des vaisseaux "in vivo" 4.2.4. Rôle physiologique du système noradrénergique a/ Rôle dans l'hypertension et l'autorégulation b/ Rôle trophique 48 4.3. Réactivité des vaisseaux cérébraux vis-à-vis du SNS pendant le développement 50 4.4. Possibilités d'interventiorVdu système nerveux cholinergique 52 4.5. Possibilité d'une influence des co-transmetteurs d'origine neuronale présents dans les terminaisons noradrénergiques et cholinergiques 53 4.5.1. Peptides 4.5.2. Serotonine 54 4.6. Les effets possibles de l'innervation sensorielle 55 CONCLUSIONS -OBJECTIFS 57 '. CCA = lommon (aratiti artery, ΚΑ -cumuli (diotiil ai In y, ICA -Intel imi carotid artery, l'CA « pottriiortommiinlctittnRaiieiY.ACA

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Age-induced changes in the aortas of rats

Cited by 5 publications

References 13 publications

Resistance training improves aortic structure in Wistar rats

Resistance training improves aortic structure in Wistar rats

Resistance training attenuates the effects of aging in the aorta of Wistar rats

Donnees Anatomophysiologiques en Faveur d'UN Role Non Vasomoteur De l'INNERVATION Autonome Des Vaisseaux Cerebraux: - Role Trophique Au Cours Du Developpementet De l'AGE Adulte. - Possibilite d'UNE Intervention Indirecte Par l'INTERMEDIAIRE De Cellules Adventicielles

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