Age-independent secular testosterone populational trends among Brazilian males

Laranja, Walker W.; Riccetto, Eduardo; Amaro, Marcelo Petean; Reis, Leonardo Oliveira

doi:10.1007/s11255-020-02425-x

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Similarly, a study of men aged 25 to 74 from three Finnish population surveys between 1972 and 2002 revealed a BMI-independent secular decline in age-speci c testosterone and free testosterone and a decrease in LH and FSH in men of more recent birth cohorts ( 16). An age-speci c, BMI-independent temporal decline in testosterone in more recent birth cohorts was also observed in a study of US Air Force veterans (18) and Brazilian men aged 19-84 years undergoing routine health examinations (15).…”

Section: Secular Trends In Testosterone Concentrationsupporting

confidence: 53%

“…Their general pro le is that of educated, active, working men aged [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50], stressed by a demanding lifestyle. While an age-independent decline in serum testosterone in men has been previously observed (14)(15)(16)(17), data on temporal trends in the incidence of hypogonadism in men are scant. Besides, limited data exist on the impact of socioeconomic status, stress, occupational burnout, and hypogonadism in men.…”

Section: Introductionmentioning

confidence: 94%

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Incidence, temporal trends, and socioeconomic aspects of male hypogonadism

Percik,

Vered,

Liel

2023

Preprint

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Little data exists on temporal changes in the incidence of definite hypogonadism and its correlation with socioeconomic status. We extracted data from the Maccabi Health Services computerized database between 2001-2017, which includes all electronic health records and laboratory data. The study included 4261 men with biochemically verified hypogonadism defined according to the European Male Study criteria. Male hypogonadism increased persistently with age in all the socioeconomic strata. 75% of the hypogonadal men had hypogonadotropic hypogonadism (HH). The overall incidence of hypogonadism increased 1.4-fold between the 2001-2009 and 2010-2017 periods, mainly due to an increase in HH. The temporal increase in hypogonadism occurred in all age groups of all socioeconomic strata but was notably more prominent in the >51 age group of the more affluent socioeconomic strata. BMI remained unchanged throughout the study period. The temporal increase in HH corresponds with previous observations of a temporal decrease in testosterone levels in men of a yet undetermined cause. Hypothetically, both could be linked to an underappreciated association between mental distress due to workplace demands and occupational burnout in specific occupations (i.e., high-tech, finance, medical) associated with more affluent populations, and reflected by decreased global happiness indices. This preliminary proposition deserves further investigation.

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Section: Secular Trends In Testosterone Concentrationsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 94%

Incidence, temporal trends, and socioeconomic aspects of male hypogonadism

Percik,

Vered,

Liel

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Low endogenous T levels are associated with a higher risk of chronic disease [1][2][3]; and all-cause mortality [4]. Several studies in western and other modernised countries have found an ageindependent secular decline in men's serum total testosterone (TT) of approximately 1% per year, beginning in the 1970s [5][6][7][8][9][10][11][12]. This downwards secular trend in T is only partly explained by the concurrent rise in BMI over the late 20 th century [5,6].…”

Section: Introductionmentioning

confidence: 99%