Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies

Whittaker, Joseph; Wu, Kexin

doi:10.1016/j.jsbmb.2021.105878

Cited by 18 publications

(16 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, a stable metabolic environment is very important for spermatogenesis. Studies have shown that low-fat diets can reduce male T levels by 10 to 15%, and vegetarians can reduce T levels by 26% ( 34 ). According to transcriptomic analysis, the genes with downregulated expression were mainly enriched in the lipid catabolic process, fat digestion or absorption, and fatty acid metabolic pathway, especially n-6 polyunsaturated fatty acid metabolism (arachidonic acid metabolism and linoleic acid metabolism), in the removal group.…”

Section: Discussionmentioning

confidence: 99%

Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches

Yang

Liu

Wang

et al. 2022

Journal of Biological Chemistry

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches

Yang

Liu

Wang

et al. 2022

Journal of Biological Chemistry

View full text Add to dashboard Cite

“…However, an overview of the available studies suggests at least similar pathophysiological mechanisms. Low-fat diets appear to decrease testicular T production and circulating T levels in men, especially those of European ancestry [ 40 ]. Wang et al precisely calculated that a reduction in dietary fat intake (and increase in fiber) resulted in 12% lower circulating androgen levels without changing the clearance [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Macronutrients Composition, Physical Activity and Serum Androgen Concentration in Young Women with Polycystic Ovary Syndrome

Mizgier¹,

Watrowski

Opydo-Szymaczek

et al. 2021

Nutrients

View full text Add to dashboard Cite

The roles of dietary macronutrients and physical activity (PA) in patients with PCOS have not been sufficiently reported, especially in adolescent girls. To address this knowledge gap, we evaluated the associations between serum concentrations of total testosterone (tT), free testosterone (fT), androstenedione (A), dehydroepiandrosterone-sulfate (DHEA-S), sex hormone-binding globulin (SHBG) and dietary macronutrients intake as well as different types and levels of PA. The study population consisted of 96 girls of Caucasian ancestry, aged 14–18 years: 61 participants with polycystic ovary syndrome (PCOS) and 35 healthy controls. Serum tT, fT, A, DHEA-S, and SHBG were determined in fasting blood. Macronutrient intake and PA levels were assessed by using the three-day food record method and the Beliefs and Eating Habits Questionnaire (KomPAN), respectively. We found several positive correlations between dietary macronutrients such as total fat, saturated fatty acids (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA), and hormonal parameters across the entire cohort and in healthy girls. A positive correlation between SHBG and total protein consumption as well as an inverse correlation between SHBG and carbohydrate intake could be determined. No correlation between androgens and macronutrients was found in the PCOS group. In contrast, we observed an inverse correlation between androgen concentrations (except of DHEA-S) and “work/school” and/or “leisure time” PA only in PCOS patients. Moreover, the hormone levels differed according to PA intensity. In conclusion, the impact of diet and PA was strikingly different in adolescents with and without PCOS. These findings indicate that disturbed hormonal homeostasis in PCOS, at least in the youngest patients, likely “overtrump” dietary influences, and otherwise, PA offers a therapeutic potential that requires further evaluation of the long-term effects in randomized studies. (ClinicalTrial.gov Identifier: NCT04738409.)

show abstract

“…Cholesterol, a dietary fat component, is one of the building blocks for testosterone production [81]. Considering that high-fat diets (HFD) increase cholesterol levels, increases in dietary fat consumption have been suggested to potentially result in an increase in testosterone production [85]. Several studies have examined the effect of HFD on circulating testosterone concentrations [85][86][87].…”

Section: High-fat Diets and Dietary Fatsmentioning

confidence: 99%

“…Considering that high-fat diets (HFD) increase cholesterol levels, increases in dietary fat consumption have been suggested to potentially result in an increase in testosterone production [85]. Several studies have examined the effect of HFD on circulating testosterone concentrations [85][86][87]. One study examined the effect of ketogenic (KD) and non-ketogenic (NKD) diets on strength, body composition, and hormonal profile in resistance-trained men [84].…”

Section: High-fat Diets and Dietary Fatsmentioning

confidence: 99%

“…An investigation in women reported that a diet that included 40% of its calories from dietary fat was superior for increasing testosterone and estrogen concentrations compared to a diet whose total fat intake was 20% of its total caloric intake [89] (described in Table 2). A recent systematic review investigated the effect of a LFD on testosterone concentrations in men [85]. The LFD had a small-to-moderate effect on decreasing total testosterone concentrations compared to the HFD.…”

Section: High-fat Diets and Dietary Fatsmentioning

confidence: 99%

See 1 more Smart Citation

Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations

2021

View full text Add to dashboard Cite

Elevations in the circulating concentration of androgens are thought to have a positive effect on the anabolic processes leading to improved athletic performance. Anabolic-androgenic steroids have often been used by competitive athletes to augment this effect. Although there has been concerted effort on examining how manipulating training variables (e.g., intensity and volume of training) can influence the androgen response to exercise, there has been much less effort directed at understanding how changes in both macronutrient and micronutrient intake can impact the androgen response. Thus, the focus of this review is to examine the effect that manipulating energy and nutrient intake has on circulating concentrations of testosterone and what the potential mechanism is governing these changes.

show abstract

Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies

Cited by 18 publications

References 74 publications

Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches

Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches

Association of Macronutrients Composition, Physical Activity and Serum Androgen Concentration in Young Women with Polycystic Ovary Syndrome

Manipulation of Dietary Intake on Changes in Circulating Testosterone Concentrations

Contact Info

Product

Resources

About