Age, gender, and hemispheric differences in iron deposition in the human brain: An in vivo MRI study

Assessing Abnormal Iron Content in the Deep Gray Matter of Patients with Multiple Sclerosis versus Healthy Controls

“…31,32 In previous articles, we introduced the concept of a high-iron content region and normal-iron-content region. 18,25 This made it possible to study not only smaller increases in iron content more confidently but also to study both the average iron content per pixel and the normalized area of increased iron content with age, which showed different and interesting results as mentioned earlier.…”

Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain: a light and electron microscopic study by the perfusion-Perls and -Turnbull methods

“…Recent magnetic resonance imaging (MRI) studies of the human brain also demonstrated such increased iron accumulation with age in these brain regions (Drayer et al, 1986;Xu et al, 2008).…”

Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals

“…1 Brain iron has been investigated in healthy individuals in both postmortem 1,2 and, more recently, in vivo studies with the use of different MR-based techniques. [3][4][5][6][7][8][9][10][11] Increased iron levels predominantly occur in brain subcortical deep gray matter (SDGM) structures such as the caudate, putamen, thalamus, red nucleus, and substantia nigra. Furthermore, it has been found that brain iron accumulation is influenced by sex.…”