Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals

Hagemeier, Jesper; Dwyer, Michael G.; Bergsland, Niels; Schweser, Ferdinand; Magnano, Christopher; Heininen-Brown, Mari; Ramasamy, Deepa P.; Carl, Ellen; Kennedy, Cheryl; Melia, Rebecca; Polak, Paul; Deistung, Andreas; Geurts, Jeroen J. G.; Reichenbach, Jürgen R.; Zivadinov, Robert

doi:10.3174/ajnr.a3569

Cited by 28 publications

(37 citation statements)

References 44 publications

(74 reference statements)

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“…There is emerging scientific evidence that the iron content increases with age also within the thalamus. 43 However, since iron content in the thalamus is lower than in the basal ganglia, 44 this issue is unlikely to have significantly affected the main finding of our study. We also note that we failed to fit lacune count values into a normal distribution.…”

Section: Discussionmentioning

confidence: 68%

Thalamic Fractional Anisotropy Predicts Accrual of Cerebral White Matter Damage in Older Subjects with Small-Vessel Disease

Cavallari

Moscufo

Meier

et al. 2014

J Cereb Blood Flow Metab

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White matter hyperintensities (WMHs) and lacunes are magnetic resonance imaging hallmarks of cerebral small-vessel disease, which increase the risk of stroke, cognitive, and mobility impairment. Although most studies of cerebral small-vessel disease have focused on white matter abnormalities, the gray matter (GM) is also affected, as evidenced by frequently observed lacunes in subcortical GM. Diffusion tensor imaging (DTI) is sensitive to subtle neurodegenerative changes in deep GM structures. We explored the relationship between baseline DTI characteristics of the thalamus, caudate, and putamen, and the volume and subsequent accrual of WMHs over a 4-year period in 56 community-dwelling older (X75 years) individuals. Baseline thalamic fractional anisotropy (FA) was an independent predictor of WMH accrual. WMH accrual also correlated with baseline lacune count and baseline WMH volume, the latter showing the strongest predictive power, explaining 27.3% of the variance. The addition of baseline thalamic FA in multivariate modeling increased this value by 70%, which explains 46.5% of the variance in WMH accrual rate. Thalamic FA might serve as a novel predictor of cerebral small-vessel disease progression in clinical settings and trials. Furthermore, our findings point to the possibility of a causal relationship between thalamic damage and the accrual of WMHs.

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Section: Discussionmentioning

confidence: 68%

Thalamic Fractional Anisotropy Predicts Accrual of Cerebral White Matter Damage in Older Subjects with Small-Vessel Disease

Cavallari

Moscufo

Meier

et al. 2014

J Cereb Blood Flow Metab

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“…As the pulvinar was not identified in this manner, the most representative section was outlined for each patient using a semiautomated contouring technique (Fig 1). 22 The SWI-filtered phase image processing method and reproducibility were discussed in a previous study involving reliable scan-rescan analysis in a subset of 6 patients with MS and 6 healthy volunteers. 5 Voxels having a mean phase value 2 SDs below normal mean phase were identified on a structure-bystructure basis, as previously described, with normal mean phase identified from 330 healthy volunteers aged 8 -87 years.…”

Section: Mr Imaging Acquisition and Analysismentioning

confidence: 99%

Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

Modica

Zivadinov²,

Dwyer

et al. 2014

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:There is a well-established correlation between deep gray matter atrophy and cognitive dysfunction in MS. However, the cause of these signs of neurodegeneration is poorly understood. Iron accumulation in the deep gray matter is higher in patients with MS compared with age-and sex-matched healthy controls, and could contribute to disease progression. Our objective was to evaluate the relationship between iron and cognition in several deep gray matter structures while accounting for the influence of volume loss.

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“…SWI-filtered phase has been proposed as a method to indirectly measure increased iron content [Haacke et al 2004;Hagemeier et al 2013a]. MP-LPV was significantly lower in the RRMS group than in HCs at baseline in the total SDGM and a number of its component regions (caudate, putamen, globus pallidus, thalamus, and pulvinar nucleus), suggesting higher iron content in the SDGM of MS patients.…”

Section: Discussionmentioning

confidence: 99%

A pilot, longitudinal, 24-week study to evaluate the effect of interferon beta-1a subcutaneous on changes in susceptibility-weighted imaging-filtered phase assessment of lesions and subcortical deep-gray matter in relapsing–remitting multiple sclerosis

Zivadinov

Dwyer

Marković-Pleše

et al. 2015

Ther Adv Neurol Disord

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Background: Studies have shown a relationship between increased iron content and clinical progression, cognitive impairment, and brain atrophy in patients with multiple sclerosis. Altered phase, as determined by susceptibility-weighted imaging (SWI), can potentially capture iron content changes. Objective: The objective of this study was to investigate phase changes in white matter (WM) lesions and subcortical deep-gray matter (SDGM) of patients with relapsing-remitting (RR) MS treated with interferon beta-1a administered subcutaneously versus untreated healthy controls (HCs). Methods: We conducted a 24-week, nonrandomized, open-label pilot study of 23 patients with RRMS receiving interferon beta-1a administered subcutaneously and 15 HCs. Patients were imaged on a 3T scanner at baseline, 12, and 24 weeks; changes in phase behavior in WM lesions and regional SDGM [mean phase of low-phase voxels (MP-LPV)], and in SDGM volumes, were measured. Between-and within-group changes were tested using nonparametric statistics adjusted for multiple comparisons. Results: The number (p = 0.003) and volume (p < 0.001) of phase WM lesions both significantly decreased among RRMS patients over 24 weeks. At baseline, MP-LPV was lower (suggestive of greater iron content) in total SDGM among RRMS patients versus HCs (p = 0.002). Week 24 MP-LPV changes from baseline were not significantly different between groups in total SDGM or any region except the putamen (−0.0025 radians in RRMS patients versus 0.0035 radians in HCs; p = 0.041). Conclusions: Over 24 weeks, phase lesions were reduced significantly in the RRMS group. These preliminary results suggest that SWI-filtered phase may become a useful tool for monitoring RRMS disease activity.

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Effect of Age on MRI Phase Behavior in the Subcortical Deep Gray Matter of Healthy Individuals

Cited by 28 publications

References 44 publications

Thalamic Fractional Anisotropy Predicts Accrual of Cerebral White Matter Damage in Older Subjects with Small-Vessel Disease

Thalamic Fractional Anisotropy Predicts Accrual of Cerebral White Matter Damage in Older Subjects with Small-Vessel Disease

Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

A pilot, longitudinal, 24-week study to evaluate the effect of interferon beta-1a subcutaneous on changes in susceptibility-weighted imaging-filtered phase assessment of lesions and subcortical deep-gray matter in relapsing–remitting multiple sclerosis

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