Age Differences in the Baroreceptor Response of Rats

Rothbaum, Donald A.; Shaw, David; Angell, Charles S.; Shock, N. W.

doi:10.1093/geronj/29.5.488

Cited by 49 publications

(15 citation statements)

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“…The results after atropine administration indicate that the reduced bradycardiac response to sudden silence in aged rats is caused by a reduction of stressinduced parasympathetic responsivity in old animals. In accordance with this finding, age-related decreases in parasympathetically mediated cardiovascular responses were reported in the magnitude of the baroreceptor reflex-induced bradycardia (22) and reduced heart rate variability (7).…”

Section: Discussionsupporting

confidence: 76%

Behavioral and cardiac responses to mild stress in young and aged rats: Effects of amphetamine and vasopressin

Buwalda

Koolhaas

Bohus

1992

Physiology & Behavior

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Section: Discussionsupporting

confidence: 76%

Behavioral and cardiac responses to mild stress in young and aged rats: Effects of amphetamine and vasopressin

Buwalda

Koolhaas

Bohus

1992

Physiology & Behavior

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“…Age-related decreases in parasympathetically mediated cardiovascular responses were found in the magnitude of the baroreceptor reflex-induced bradycardia [21], the diminution of bradycardia resulting from an emotional stress in rats [19] and reduced heart rate variability in man [5]. The present results may be viewed as an extension of this: aging resulting in a reduction of a vagally mediated response in the rat to an unconditioned, non-aversive physiological stimulus such as eating a small meal.…”

Section: Discussionsupporting

confidence: 58%

“…Physiological and neuroendocrine stress responses are markedly affected by age in animals and man [5,18,19,21,22]. Previous studies in our laboratory have shown an age-related reduction in the initial bradycardia to a conditioned emotional stress (fear of inescapable footshock) [19].…”

Section: Introductionmentioning

confidence: 96%

Reduced preabsorptive insulin response in aged rats: differential effects of amphetamine and arginine-vasopressin

Buwalda¹,

Strubbe²,

Hoes³

et al. 1991

Journal of the Autonomic Nervous System

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“…One possible interpretation may be reduced baroreceptor reflex sensitivity with age. The baroreceptor reflex sensitivity has been repeatedly reported to be reduced with aging in animals 39 and humans. 37 Reduced baroreceptor reflex sensitivity, which may result from anatomic changes in the receptors or decreased arterial wall compliance secondary to aging, possibly increases sympathetic nerve activity.…”

mentioning

confidence: 95%

Age-related changes in muscle sympathetic nerve activity in essential hypertension.

et al. 1989

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To investigate the pathophysiological role of the sympathetic nervous system in essential hypertension, this study recorded the muscle sympathetic nerve activity (MSNA) of the tibial nerve and examined the age-related changes in patients with essential hypertension and in normotensive persons. There were 43 normotensive subjects (16-69 years old) and 63 patients with essential hypertension (18-67 years old) in the study. The MSNA at rest, recorded by microneurography, was evaluated by burst rate (bursts/min), burst incidence (bursts/100 heart beats), and spike frequency (spikes/min). The MSNA recording showed a high reproducibility with a correlation coefficient of 0.86 (p<0.0l) in repeated studies. The MSNA was significantly greater in the hypertensive patients than in the normotensive subjects, irrespective of activity units (p<0.0l), and this finding was consistent in the young (30 years old or less), middle-aged (31-50 years old), and old groups (51 years old or more). Furthermore, MSNA showed a significant positive correlation with age both in the normotensive subjects (r=0.43, p<0.01 for burst rate; r=0.49, /?<0.01 for burst incidence; and r=0.50, p<0.01 for spike frequency) and in the hypertensive patients (r=0.40,/><0.01 for burst rate; r=0.44,p<0.01 for burst incidence; and r=0.40, /><0.01 for spike frequency). Although there was a significant positive correlation between plasma norepinephrine concentration and MSNA in the hypertensive patients and the normotensive subjects, the difference in plasma norepinephrine concentration between the two groups was not significant at any age level. These results indicate that sympathetic nerve activity is increased in patients with essential hypertension at any age level and plays a long-term role in the development and maintenance of blood pressure elevation. (Hypertension 1989; 13:870-877)

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Age Differences in the Baroreceptor Response of Rats

Cited by 49 publications

References 0 publications

Behavioral and cardiac responses to mild stress in young and aged rats: Effects of amphetamine and vasopressin

Behavioral and cardiac responses to mild stress in young and aged rats: Effects of amphetamine and vasopressin

Reduced preabsorptive insulin response in aged rats: differential effects of amphetamine and arginine-vasopressin

Age-related changes in muscle sympathetic nerve activity in essential hypertension.

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