Age-dependent recruitment of neutrophils by fetal endothelial cells: implications in scarless wound healing

Naik‐Mathuria, Bindi; Zhu, Xi; Yu, Li; Cass, Darrell L.

doi:10.1016/j.jpedsurg.2006.09.058

Cited by 28 publications

(24 citation statements)

References 24 publications

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“…1, level VII), because the plasticity, reprogrammability, natural developmental timing and physiologic consequences of endothelial functional heterogenity are not fully understood. Recent findings support another intriguing possibility related to phenotypic endothelial variations: Endothelial cells may be involved in scarless wound healing via regulation of leukocyte transmigration (144). Overall, vascular problems currently represent a major source of problems in organ engineering.…”

Section: Organ Level: Integration Of All Memory Mechanismsmentioning

confidence: 70%

Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration

et al. 2008

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When a sheep loses its tail, it cannot regenerate it in the manner of lizards. On the other hand, it is possible to clone mammals from somatic cells, showing that a complete developmental program is intact in a wounded sheep's tail the same way it is in a lizard. Thus, there is a requirement for more than only the presence of the entire genetic code in somatic cells for regenerative abilities. Thoughts like this have motivated us to assemble more than just a factographic synopsis on tissue regeneration. As a model, we review skin wound healing in chronological order, and when possible, we use that overview as a framework to point out possible mechanisms of how damaged tissues can restore their original structure. This article postulates the existence of tissue structural memory as a complex distributed homeostatic mechanism. We support such an idea by referring to an extremely fragmented literature base, trying to synthesize a broad picture of important principles of how tissues and organs may store information about their own structure for the purposes of regeneration. Selected developmental, surgical, and tissue engineering aspects are presented and discussed in the light of recent findings in the field. (Pediatr Res 63: 502-512, 2008)

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Section: Organ Level: Integration Of All Memory Mechanismsmentioning

confidence: 70%

Memory Encoded Throughout Our Bodies: Molecular and Cellular Basis of Tissue Regeneration

et al. 2008

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“…93 Nevertheless, fetal cells seem to be promising as a few specific gene expression patterns are known to be essential for scarless wound healing. 93,100 These findings may influence research on bone-marrowederived stem cells for skin repair 101 as little is known about their specific wound gene expression patterns. New studies also focus on the role of hair follicle-bound epithelial stem cells in cutaneous wound healing.…”

Section: Discussionmentioning

confidence: 99%

Wound healing in the 21st century

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Szeimies

Prantl

et al. 2010

Journal of the American Academy of Dermatology

323

230

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“…23,27,28 Neutrophils are also present in fetal wound healing, but there are important differences in the expression pattern and function of neutrophils in fetal versus adult wound healing 29 that may distinguish whether a wound heals regeneratively or with a scar. 30 Adult neutrophils are characterized by a much higher expression of cell adhesion molecules than the fetal neutrophils, 31 which may induce increased neutrophil-endothelial interaction and thereby increased migration of neutrophils into the wound bed that then can contribute to scarring phenotype of the adult wounds. 32 In comparison, fetal wounds have in fact been demonstrated to have a smaller fraction of neutrophils.…”

Section: The Inflammatory Stage Of Wound Healingmentioning

confidence: 99%