Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

Williams, Byron; Granholm, Ann‐Charlotte; Sambamurti, Kumar

doi:10.1016/j.neulet.2006.11.040

Cited by 39 publications

(37 citation statements)

References 43 publications

(49 reference statements)

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“…However, these two different pathways involve mutual crosstalk [26], which can also be confirmed by the findings of the present study. In this study, the p-Erk/t-Erk ratios and CREB levels in the soleus of diabetic rats were not affected by treadmill exercise.…”

Section: Discussionsupporting

confidence: 91%

Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-phosphatidylinositol 3-kinase activation in the soleus of diabetic rats

Chae

Jung

et al. 2011

J Physiol Biochem

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We investigated the effects of treadmill exercise performed regularly for 6 weeks on the levels of nerve growth factor (NGF), tyrosine kinase A and p75 receptors, phosphatidylinositol 3-kinase (PI3-K), mitogen-activated protein kinase/extracellular signal-regulated kinase (Erk) 1,2, cyclic AMP response element-binding protein (CREB), and caspase-3 in the soleus of rats with streptozotocin (STZ)-induced diabetes. Thirty-two male Sprague-Dawley rats were divided into the following four groups: (1) normal control group (NCG; n = 8), (2) normal exercise group (NEG; n = 8), (3) diabetes control group (DCG; n = 8), and (4) diabetes exercise group (DEG; n = 8). Diabetes was induced by intraperitoneal injection of STZ (55 mg/kg dissolved in 0.05 M citrate buffer, pH 4.5). Rats were subjected to treadmill exercise 5 days a week for 6 weeks. The protein level of NGF significantly increased in the NEG and DEG (p < 0.001), whereas the levels of tyrosine kinase A and p75 receptors significantly increased in the NEG (p < 0.001). The levels of t-PI3-K, p-PI3-K, and p-CREB, and the p-CREB/t-CREB ratio significantly increased in the NEG (p < 0.001, respectively). The p-PI3-K/t-PI3-K ratio significantly increased in the DEG (p < 0.001). The p-Erk1/t-Erk1 ratio significantly increased in the NEG (p < 0.001), whereas the p-Erk2/t-Erk2 ratio significantly decreased in the DCG and DEG (p < 0.001). The caspase-3 level significantly increased in the DCG compared with that in the DEG (p < 0.001). These results suggest that treadmill exercise increases NGF levels and accelerates p-PI3-K activation in order to suppress apoptotic cell death in the soleus muscle of diabetic rats.

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Section: Discussionsupporting

confidence: 91%

Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-phosphatidylinositol 3-kinase activation in the soleus of diabetic rats

Chae

Jung

et al. 2011

J Physiol Biochem

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“…Earlier studies on PS1 expression in the developing brain and the impaired neuronal development in PS1 null mice suggested that factors involved in neuronal differentiation and survival influence the PS1 protein level (Ribaut-Barassin et al 2003;Saura et al 2004). Some of these factors (TGF-b, NGF, BDNF) are neurotrophic in nature and show age dependent expression (Silhot et al 2005;Williams et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Age and Sex Dependent Alteration in Presenilin Expression in Mouse Cerebral Cortex

Thakur

Ghosh

2007

Cell Mol Neurobiol

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(1) Presenilin (PS) expression is regulated by several cellular and extracellular factors which change with age and sex. Both age and sex are key risk factors for Alzheimer's disease (AD), which is linked to mutations in PS genes. (2) We have analyzed the effect of age and sex on PS expression by northern hybridization and western blot analysis using the cerebral cortex of adult (24 +/- 2 weeks) and old (65 +/- 5 weeks) mice. (3) Our results demonstrate that PS1 was downregulated and PS 2 was upregulated in old mice of both sexes. The level of PS 1 was relatively higher and that of PS 2 was lower in female than male mice of same age group. Taken together, these findings show age and sex dependent alteration in PS expression, which in turn may influence the signal transduction pathways and consequently brain functions.

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“…16,17) Figure 3A shows that Re and Rd could activate ERK and Akt with phosphorylation as much as NGF, suggesting that Re and Rd are closely related with the NGF-TrkA signaling pathway (Fig. 3B).…”

Section: Effect Of Ginsenosides On the Cholinergic Markers In N2a Cellsmentioning

confidence: 95%

Ginsenoside Re and Rd Enhance the Expression of Cholinergic Markers and Neuronal Differentiation in Neuro-2a Cells

Kim

et al. 2014

Biological & Pharmaceutical Bulletin

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Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

Cited by 39 publications

References 43 publications

Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-phosphatidylinositol 3-kinase activation in the soleus of diabetic rats

Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-phosphatidylinositol 3-kinase activation in the soleus of diabetic rats

Age and Sex Dependent Alteration in Presenilin Expression in Mouse Cerebral Cortex

Ginsenoside Re and Rd Enhance the Expression of Cholinergic Markers and Neuronal Differentiation in Neuro-2a Cells

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