Age-dependent effects of environmental enrichment on brain networks and spatial memory in Wistar rats

Sampedro-Piquero, Patricia; Begega, Azucena; Zancada-Menendez, C.; Izquierdo, Marcelino Cuesta; Árias, Jorge L.

doi:10.1016/j.neuroscience.2013.06.003

Cited by 25 publications

(16 citation statements)

References 78 publications

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“…Our finding that spatial memory is improved by EE in aged rats is consistent with previous studies (Baraldi et al, 2013;Frick and Fernandez, 2003;Sampedro-Piquero et al, 2013). For example, among aged rodents, EE has shown to improve the learning of the Morris water maze , Hebb-Williams maze (Cummins et al, 1973), incidental learning (Warren et al, 1982) and reverses short- Fig.…”

Section: Discussionsupporting

confidence: 92%

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Sampedro-Piquero

Árias

Begega

2014

Experimental Gerontology

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Section: Discussionsupporting

confidence: 92%

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Sampedro-Piquero

Árias

Begega

2014

Experimental Gerontology

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“…), in particular, memory processes (Sampedro‐Piquero et al . ). Actually, EE during adolescence restores adult neurogenesis in the dentate gyrus and mitigates the effects of alcohol in neonatal rats (Hamilton et al .…”

Section: Discussionmentioning

confidence: 97%

Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence

et al. 2018

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Binge drinking (BD) is a common pattern of ethanol (EtOH) consumption by adolescents. The brain effects of the acute EtOH exposure are well-studied; however, the long-lasting cognitive and neurobehavioral consequences of BD during adolescence are only beginning to be elucidated. Environmental enrichment (EE) has long been known for its benefits on the brain and may serve as a potential supportive therapy following EtOH exposure. In this study, we hypothesized that EE may have potential benefits on the cognitive deficits associated with BD EtOH consumption. Four-week-old C57BL/6J male mice were exposed to EtOH following an intermittent 4-day drinking-in-the-dark procedure for 4 weeks. Then they were exposed to EE during EtOH withdrawal for 2 weeks followed by a behavioral battery of tests including novel object recognition, novel location, object-in-place, rotarod, beam walking balance, tail suspension, light-dark box and open field that were run during early adulthood. Young adult mice exposed to EE significantly recovered recognition, spatial and associative memory as well as motor coordination skills and balance that were significantly impaired after adolescent EtOH drinking with respect to controls. No significant permanent anxiety or depressive-like behaviors were observed. Taken together, an EE exerts positive effects on the long-term negative cognitive deficits as a result of EtOH consumption during adolescence.

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“…Much of this work was developed from early rodent studies identifying that EE-exposed rats developed thicker cortices compared to controls (Diamond et al, 1964 ; Bennett et al, 1969 ; Rosenzweig and Bennett, 1969 ). Later studies contributed to this initial finding with analyses showing morphological changes in dendritic branch length and increased spine densities (Greenough et al, 1973 ) that are associated with improved learning (Frick and Fernandez, 2003 ; Leggio et al, 2005 ; Sampedro-Piquero et al, 2013 ). In addition to improved learning, EE increases exploratory behavior (Levitsky and Barnes, 1972 ), including open arm exploration on the elevated plus maze (Fernandez-Teruel et al, 1997 ; Fernández-Teruel et al, 2002 ) reflecting reduced anxiety.…”

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment Increases Glucocorticoid Receptors and Decreases GluA2 and Protein Kinase M Zeta (PKMζ) Trafficking During Chronic Stress: A Protective Mechanism?

Zanca

Braren

Maloney

et al. 2015

Front. Behav. Neurosci.

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Environmental enrichment (EE) housing paradigms have long been shown beneficial for brain function involving neural growth and activity, learning and memory capacity, and for developing stress resiliency. The expression of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA2, which is important for synaptic plasticity and memory, is increased with corticosterone (CORT), undermining synaptic plasticity and memory. Thus, we determined the effect of EE and stress on modulating GluA2 expression in Sprague-Dawley male rats. Several markers were evaluated which include: plasma CORT, the glucocorticoid receptor (GR), GluA2, and the atypical protein kinase M zeta (PKMζ). For 1 week standard-(ST) or EE-housed animals were treated with one of the following four conditions: (1) no stress; (2) acute stress (forced swim test, FST; on day 7); (3) chronic restraint stress (6 h/day for 7 days); and (4) chronic + acute stress (restraint stress 6 h/day for 7 days + FST on day 7). Hippocampi were collected on day 7. Our results show that EE animals had reduced time immobile on the FST across all conditions. After chronic + acute stress EE animals showed increased GR levels with no change in synaptic GluA2/PKMζ. ST-housed animals showed the reverse pattern with decreased GR levels and a significant increase in synaptic GluA2/PKMζ. These results suggest that EE produces an adaptive response to chronic stress allowing for increased GR levels, which lowers neuronal excitability reducing GluA2/PKMζ trafficking. We discuss this EE adaptive response to stress as a potential underlying mechanism that is protective for retaining synaptic plasticity and memory function.

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Age-dependent effects of environmental enrichment on brain networks and spatial memory in Wistar rats

Cited by 25 publications

References 78 publications

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence

Environmental Enrichment Increases Glucocorticoid Receptors and Decreases GluA2 and Protein Kinase M Zeta (PKMζ) Trafficking During Chronic Stress: A Protective Mechanism?

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