Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise

Luo, Lan; Li, Rui; Wang, Guiping; Chen, Jingsi; Chen, Liangkai; Qin, Li–Qiang; Yu, Zengli; Wan, Zhongxiao

doi:10.1039/d1fo03241k

Cited by 5 publications

(2 citation statements)

References 48 publications

(84 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Allobaculum , which is involved in butyric acid production [ 48 , 49 ], increases following the consumption of a high fat diet in rodents that produces cognitive impairments [ 38 , 50 , 51 ]. While this suggest that increased levels of Allobaculum may be related to suboptimal health, other studies have reported that voluntary exercise can lead to enhanced abundance of Allobaculum [ 52 , 53 ]. Thus, future studies should attempt to manipulate Allobaculum abundance directly to examine the impact on cognitive function and metabolic health.…”

Section: Discussionmentioning

confidence: 98%

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

et al. 2022

View full text Add to dashboard Cite

Declining health, gut dysbiosis, and cognitive impairments are hallmarks of advanced age. While caloric restriction is known to robustly extend the healthspan and alter gut microbiome composition, it is difficult maintain. Time-restricted feeding or changes in dietary macronutrient composition could be feasible alternatives for enhancing late life cognitive and physical health that are easier to comply with for extended periods of time. To investigate this possibility, 8-month-old rats were placed on time-restricted feeding with a ketogenic or micronutrient- and calorically matched control diet for 13 months. A third group of rats was permitted to eat standard chow ad libitum during this time. At 22 months, all rats were tested on a biconditional association task and fecal samples were collected for microbiome composition analysis. Regardless of dietary composition, time-restricted-fed rats had better cognitive performance than ad libitum-fed rats. This observation could not be accounted for by differences in motivation, procedural or sensorimotor impairments. Additionally, there were significant differences in gut microbiome diversity and composition between all diet conditions. Allobaculum abundance was associated with cognitive task performance, indicating a link between gut health and cognitive outcomes in aged subjects. Overall, time restricted feeding had the largest influence on cognitive performance in aged rats.

show abstract

Section: Discussionmentioning

confidence: 98%

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

et al. 2022

View full text Add to dashboard Cite

show abstract

“…At present, most studies used heat‐treated foods for feeding mice to study the effects of dietary AGEs intake on organismal health (Luo, Li, et al, 2022; Roncero‐Ramos et al, 2013). However, extensive heat processing foods contain various antinutritional and toxic compounds derived from the Maillard reaction (e.g., acrylamide [Quan et al, 2022], heterocyclic aromatic amines [Dong et al, 2020], and 5‐hydroxymethylfurfural [Han et al, 2019; Pérez‐Burillo et al, 2019]).…”

Section: Introductionmentioning

confidence: 99%

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

Wen

Zhang

Xia

et al. 2023

eFood

View full text Add to dashboard Cite

This study evaluated the biological effects of exogenous advanced glycation end products (AGEs) on the induction of chronic kidney disease and the dose‐effect relationship. Male C57BL/6 mice were placed on four diets, including saline and three other diets differing only in AGEs content (low‐AGEs [LA], medium‐AGEs [MA], and high‐AGEs [HA] ratio, 1:3:5) for 4 weeks. With the increasing intake of AGEs, mice developed a significant increase in blood glucose and lipid levels, the fluorescence intensity of AGEs, Nε‐(carboxymethyl)‐lysine, Nε‐(carboxyethyl)‐lysine, and malondialdehyde levels, whereas their superoxide dismutase activity and glutathione levels were decreased significantly. HA had the highest urinary protein levels and the lowest creatinine clearance compared to the other groups. These suggested that AGEs are an essential contributor to increasing oxidative stress levels and intake of high‐level AGEs induces more severe kidney function impairment. Meanwhile, the AGEs intake damaged the kidney structure in a dose‐dependent manner, as evidenced by granular degeneration of kidney tubular epithelial cells and inflammatory cell infiltration. These findings shed light on the detrimental impacts of AGEs on human kidneys, which also will help reveal a dose‐effect relationship of AGEs.

show abstract

Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

et al. 2023

View full text Add to dashboard Cite

Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise

Abstract: To determine whether high fat diet (HFD) combined with advanced glycation end products (AGEs) diet will induce worse cognitive impairment than HFD per se, and whether voluntary exercise is capable...

Cited by 5 publications

References 48 publications

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

Twelve Months of Time-Restricted Feeding Improves Cognition and Alters Microbiome Composition Independent of Macronutrient Composition

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

Contact Info

Product

Resources

About