Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

Zhang, Yuhe; Yan, Chen; Yuan, Shushu; Yu, Qingxia; Fu, Jianjiong; Chen, Luyun; Liu, Jiaming; He, Yue

doi:10.1007/s00221-023-06632-7

Cited by 8 publications

(4 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, this natural compound relieved also learning and memory deficits and ameliorated hippocampus histological lesions in Vascular dementia rats [121] . In another work Zhang et al [122] . studied the neuroprotective activity of gastrodin against cognitive impairment via regulating gut microbiota.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…Moreover, this natural compound relieved also learning and memory deficits and ameliorated hippocampus histological lesions in Vascular dementia rats. [121] In another work Zhang et al [122] studied the neuroprotective activity of gastrodin against cognitive impairment via regulating gut microbiota. They found that gastrodin improved cognitive deficits and Aβ deposition in APP/PS1 mice via increasing Bcl-2 level and decreasing Bax level and down-regulation neuronal apoptosis.…”

Section: Neuroprotective Effectmentioning

confidence: 99%

See 1 more Smart Citation

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

El Menyiy,

Elouafy,

Moubachir

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti‐inflammatory, antioxidant, anti‐apoptotic, and anti‐tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.

show abstract

Section: Pharmacological Propertiesmentioning

confidence: 99%

Section: Neuroprotective Effectmentioning

confidence: 99%

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

El Menyiy,

Elouafy,

Moubachir

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…This discrepancy could be the reason for the difference in aspect of Se occurrences in the soils. Such morphological distribution characteristics significantly influence the uptake of Se by plants [46][47][48][49][50].…”

Section: Distribution Characteristics Of Soil Selenium (Se) Formsmentioning

confidence: 99%

Form, Bioavailability, and Influencing Factors of Soil Selenium in Subtropical Karst Regions of Southwest China

Hu,

Xiong,

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

Karst regions are characterized by unique geological formations that pose challenges to soil fertility and plant nutrition. In this study, we investigated the distribution and interactions of selenium (Se) in soils of Zheng’an County, a representative karst region in subtropical China. The results showed that the Se enrichment in the soils of Zheng’an County was high, with total contents ranging from 0.49 to 3.87 mg/kg and an average of 1.22 mg/kg, making the area Se-rich. Despite the abundance of Se, the effective percentage of Se uptake by plants was relatively low due to the generally moderately acidic nature of the soils in the region (pH: 5.98–6.60), which encourages the conversion of the available Se into forms that are not readily accessible. In addition, the high organic matter (OM) content (21.92–127.66 g/kg) promoted Se retention by interacting with Ca2+ in carbonate rocks. In addition, the clay content (50.73% to 76.19%) enhanced Se adsorption and limited Se availability. In conclusion, this study provides a basis for soil management and ecological restoration strategies in karst landscapes, highlights new insights into the dynamics of Se, and calls for further research to elucidate the Se availability mechanism and improve the efficiency of Se uptake by plants. Meanwhile, this study provides the first systematic study of Se transport and transformation, as well as Se-enriched Gastrodia elata in karst regions, and provides a preliminary understanding of the geochemical behavior of Se in karst regions.

show abstract

“…Gas reversed the memory dysfunction in D-gal-administered AD mouse model via partly modulating the microbiota-gut-brain axis with a positive link with Firmicutes and had a negative link with Cyanobacteria, Proteobacteria, and Deferribaceters ( Fasina et al, 2022 ). Gas treatment improved cognitive deficits and Aβ deposition in APP/PS1 mice by inhibiting neuronal apoptosis via increasing the level of Bcl-2 and decreasing the level of Bax, increasing the expression levels of insulin-like growth factor-1(IGF-1) and cAMP response element-binding protein (CREB) in APP/PS1 mice, as well as rectifying the abnormal composition and structure of gut microbiota ( Zhang Y. et al, 2023 ). These studies provide scientific basis for neuroprotective roles of G. elata in AD and demonstrate the relevant mechanisms which include modulation of the gut microbiota.…”

Section: Herbal Medicine and Admentioning

confidence: 99%

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life of victims. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenic mechanism of AD and search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state of gut microbiota, has been well known for its involvement in the pathogenesis of AD. Much effort has been made in searching for approaches capable of modulating the composition of gut microbiota in recent years. Herbal medicines have attracted extensive attention in recent decades for the prevention and treatment of AD. Here, we gave an overview of the recent research progress on the modulatory effects of herbal medicines and herbal formulae on gut microbiota as well as the possible beneficial effects on AD, which may provide new insights into the discovery of anti-AD agents and their therapeutic potential for AD through modulating the composition of gut microbiota.

show abstract

Effect of gastrodin against cognitive impairment and neurodegeneration in APP/PS1 mice via regulating gut microbiota–gut–brain axis

Cited by 8 publications

References 74 publications

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Form, Bioavailability, and Influencing Factors of Soil Selenium in Subtropical Karst Regions of Southwest China

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Contact Info

Product

Resources

About