Age-dependent changes in rat liver microsomal membrane structure and functions under benzene treatment

Sukhodub, Andrey; Vi, Padalko

doi:10.1016/s0047-6374(98)00120-1

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…In other words enzymes activities increase in serum when cellular degeneration or destruction occurs in liver. In a study, it was shown that properties of membrane phospholipid were changed (Engelke et al 1993), some structural and functional changes occur under benzene treatment in rat microsomes (Sukhodub and Padalko 1999). In another study, Weaver et al (2007) investigated the effects of benzene inhalation on the epithelial cells lining the respiratory tract including bronchioles, terminal bronchioles, respiratory bronchioles and alveoli of male rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Benzene on liver functions in rats (Rattus norvegicus)

Dere

Arı

2008

Environ Monit Assess

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Rats (Rattus norvegicus) were intraperitoneally injected with a 100 mg kg(-1) dosage of benzene, a toxic and carcinogenic agent widely used for industrial purposes. Changes in lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST) activities in serum of rats were investigated at 2, 4, 8, 16, 32, and 64 h following injection. Serum physiological was administered to control group. Activities were measured using autoanalyzer. Benzene caused significant activations in LDH, ALP, and AST activities in the serum at some test hours (p < 0.05). When compared with the control groups, although an increase occurred in ALT activity, it was seem that this increase wasn't significant (p > 0.05).

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Section: Discussionmentioning

confidence: 99%

Effect of Benzene on liver functions in rats (Rattus norvegicus)

Dere

Arı

2008

Environ Monit Assess

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“…In a retrospective study of 2358 cancer cases in children in Germany, parental exposure to benzene was not associated with occurrence of childhood leukemia (Kaatsch et al, 1998). While the relationship between benzene exposure and increased incidence of childhood leukemia is not definitive, data with young and geriatric rats show that benzene damages liver microsomes in 2-yr-old rats (geriatric) to a much greater extent than in 3-mo-old animals (Sukhodub & Padalko, 1999). In essence, children may be able to cope with benzene while the aging population is far more susceptible .…”

Section: Agementioning

confidence: 98%

“…As indicated previously, aging is a factor in benzene exposure toxicity. It was suggested by Sukhodub and Padalko (1999) that in geriatric rats, benzene produced more extensive liver microsomal damage. Similarly, Soucek (1999) found that benzene exposure destroyed cytochrome P-450 content in human liver microsomes.…”

Section: S Kacew and I Lemairementioning

confidence: 99%

Recent Developments in Benzene Risk Assessment

Kacew¹,

Lemaire²

2000

Journal of Toxicology and Environmental Health Part A

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“…It is unwise to extrapolate from a healthy adult male to female or geriatric population. The activity of aminopyrine N-demethylase enzyme was investigated with different ages and found to decrease with age 20 . Another study showed that the activity of aminopyrine N-demethylase and aniline hydroxylase enzymes decreased with age in female SD rats until 1.5 months then the activity of enzyme showed a significant increase 21 .…”

Section: Fig 4: Percentage Of Formaldehyde Formed In Old Male and Fementioning

confidence: 99%

Untitled

2012

IJPSR

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Mitragyna speciosa Korth. is a member of the Rubiaceae family. More than 25 alkaloids have been isolated from Mitragyna speciosa. Mitragynine is the major alkaloid of this plant and is responsible for antinociceptive action. No single study is available about the effect of mitragynine on aminopyrine Ndemethylase activity in rat hepatocytes. Experiments were undertaken to evaluate the effect of mitragynine in different age groups (adult & old) of Sprague-Dawley (SD) male and female rat hepatocytes. In vitro this evaluation was assessed by different concentration of mitragynine (0.0025µM-250µM). Hepatocytes were prepared by collagenase perfusion technique. Aminopyrine N-demethylase activity was determined by measuring the quantity of formaldehyde formed. Results showed that a significant increase in aminopyrine N-demethylase activity was observed in the adult male, female and old female SD rat hepatocytes treated with 250µM mitragynine (p< 0.05). However, the old male rat did not show any significant change at any concentration of mitragynine. In conclusion this study indicates the induction of hepatic drug metabolizing enzymes by mitragynine is affected by the aging process in male but unaffected in female.

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Age-dependent changes in rat liver microsomal membrane structure and functions under benzene treatment

Cited by 9 publications

References 30 publications

Effect of Benzene on liver functions in rats (Rattus norvegicus)

Effect of Benzene on liver functions in rats (Rattus norvegicus)

Recent Developments in Benzene Risk Assessment

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