Effect of Benzene on liver functions in rats (Rattus norvegicus)

Dere, Egemen; Arı, Ferda

doi:10.1007/s10661-008-0374-7

Cited by 33 publications

(26 citation statements)

References 25 publications

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“…Associated increases in liver size and weight (hepatomegaly) in the exposed animals have also been reported [131]. Several mechanisms contribute to gasolineinduced hepatotoxicity, including the induction of cellular degeneration, downregulation of gene expression, and induction of oxidative stress [132]. Inhibition of CYP2E1, which was recently reported in animals exposed to gasoline vapors [103] is potentially deleterious to the liver.…”

Section: Hepatotoxicitymentioning

confidence: 98%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

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Section: Hepatotoxicitymentioning

confidence: 98%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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“…The metabolites of benzene, in addition to adduct formation with DNA and RNA also attach to the proteins of liver, kidney, bone marrow and stomach (Lindstrom et al, 1997;Snyder and Hedli, 1996). Dere and Ari ( 2009) reported that acutely exposed rats at dose 100 mg/kg benzene orally show an increase in the acitivity of hepatic enzymes lactate dehydrogenase (LDH), alkaline phosphatase (ALP), aspartate transaminase ( AST) and alanine aminotransferase (ALT). Another animal study indicated a decrease in P450-2E1 by 34% and induction of glutathione activity by 30% in female CD-1 mice treated with 50 mg/kg benzene for…”

Section: Acute Exposurementioning

confidence: 99%

“…All these workers, in addition to other hydrocarbons, were exposed to benzene at 4.798 mg/m 3 via inhalation. The mechanism for change in the activity of liver enzymes may be related to celluer degenaration, down regulation of gene expression, oxidative stress and related pathways stimulated in hepatocellular cytosols (Dere and Ari, 2009;Davis H. Daiker, 1996).…”

Section: Chronic Exposurementioning

confidence: 99%

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Bahadar

Mostafalou

Abdollahi

2014

Toxicology and Applied Pharmacology

212

128

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“…Exposure to benzene may cause leukemia, lymphoma, multiple myeloma, aplastic anemia, and other solid cancers [2][3][4][5][6]. In addition, benzene exposure is associated with a wide range of non-cancerous but adverse effects including alterations in pulmonary, central nervous system, hematological, hepatic, and renal functions [7][8][9][10][11]. Adverse respiratory effects of benzene include pulmonary edema, acute granular tracheitis, laryngitis, bronchitis, fibrosis, and massive hemorrhaging.…”

Section: Subjectsmentioning

confidence: 99%

Benzene exposure from the BP refinery flaring incident alters hematological and hepatic functions among smoking subjects

D’Andrea¹,

Reddy²

2017

Int J Occup Med Environ Health

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Objectives: To evaluate the health effects of benzene exposure among smoking subjects from a prolonged flaring incident that occurred at the British Petroleum (BP) refinery in Texas City, USA. Material and Methods: The study included smoking subjects who had been exposed and unexposed to the benzene release. Using medical charts, clinical data including white blood cell (WBC) counts, platelet counts, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the case of smoking subjects exposed to benzene was reviewed and analyzed. Results: A total of 791 tobacco smoking subjects (benzene-exposed: N = 733, unexposed: N = 58) were included. Benzene-exposed subjects had significantly higher levels of WBC (×10 3 /μl) counts (8±2.1 vs. 7.5±1.6, p = 0.003) and platelet (×10 3 /μl) counts (263.7±69.7 vs. 222.9±44.3, p = 0.000) as compared with the unexposed subjects. The mean hemoglobin, hematocrit, BUN, and creatinine levels did not differ significantly between the benzene-exposed and -unexposed smoking subjects. Serum levels of ALP (IU/l) was significantly elevated in the benzene-exposed subjects compared with the unexposed subjects (84.5±16.9 vs. 73.8±15.9, p = 0.002). Similarly, benzene-exposed subjects had significantly higher levels of AST and ALT as compared with those unexposed subjects. Conclusions: Despite a smoking history, residents exposed to benzene from the prolonged BP flaring incident experienced significant alterations in hematological and hepatic functions indicating their vulnerability to the risk of developing hepatic or blood related disorders. Int J Occup Med Environ Health 2017;30(6):849 -860

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Effect of Benzene on liver functions in rats (Rattus norvegicus)

Cited by 33 publications

References 25 publications

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Benzene exposure from the BP refinery flaring incident alters hematological and hepatic functions among smoking subjects

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